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Combined skin prick and patch testing enhances identification of food allergy in infants with atopic dermatitis.
J Allergy Clin Immunol 1996; 97(1 Pt 1):9-15JA

Abstract

BACKGROUND

Early recognition of dietary allergies in infants with atopic dermatitis is essential for avoidance of unnecessary elimination diets, amelioration of the skin disease, and secondary prevention of the development of multiple food allergies. Simple and accurate methods of identifying provocative foods are urgently needed.

METHODS

The usefulness of skin prick and patch tests as indicators of cow milk allergy was evaluated in 183 patients ranging in age from 2 to 36 months with double-blind, placebo-controlled (n = 118) or open (n = 65) cow milk challenges.

RESULTS

The oral cow milk challenges were interpreted as positive in 54% of both challenge types. Positive challenge rapidly elicited pruritus, urticaria, and/or exanthema in 49% of cases and delayed-onset eczematous lesions in 51%. The skin prick and patch tests gave markedly discrepant results; prick tests were positive in 67% of the cases with acute-onset reactions to milk challenge, whereas patch tests tended to be negative. Patch tests were positive in 89% of those with delayed-onset reactions, although prick tests were frequently negative.

CONCLUSIONS

The observations indicate that IgE and T cell-mediated responses to cow milk can be distinguished in atopic dermatitis. Parallel skin testing with combined prick and patch tests can significantly enhance the accuracy in diagnosis of specific dietary allergies in patients with atopic dermatitis.

Authors+Show Affiliations

Medical School, University of Tampere, Finland.No affiliation info available

Pub Type(s)

Clinical Trial
Controlled Clinical Trial
Journal Article
Research Support, Non-U.S. Gov't

Language

eng

PubMed ID

8568142

Citation

Isolauri, E, and K Turjanmaa. "Combined Skin Prick and Patch Testing Enhances Identification of Food Allergy in Infants With Atopic Dermatitis." The Journal of Allergy and Clinical Immunology, vol. 97, no. 1 Pt 1, 1996, pp. 9-15.
Isolauri E, Turjanmaa K. Combined skin prick and patch testing enhances identification of food allergy in infants with atopic dermatitis. J Allergy Clin Immunol. 1996;97(1 Pt 1):9-15.
Isolauri, E., & Turjanmaa, K. (1996). Combined skin prick and patch testing enhances identification of food allergy in infants with atopic dermatitis. The Journal of Allergy and Clinical Immunology, 97(1 Pt 1), pp. 9-15.
Isolauri E, Turjanmaa K. Combined Skin Prick and Patch Testing Enhances Identification of Food Allergy in Infants With Atopic Dermatitis. J Allergy Clin Immunol. 1996;97(1 Pt 1):9-15. PubMed PMID: 8568142.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Combined skin prick and patch testing enhances identification of food allergy in infants with atopic dermatitis. AU - Isolauri,E, AU - Turjanmaa,K, PY - 1996/1/1/pubmed PY - 1996/1/1/medline PY - 1996/1/1/entrez SP - 9 EP - 15 JF - The Journal of allergy and clinical immunology JO - J. Allergy Clin. Immunol. VL - 97 IS - 1 Pt 1 N2 - BACKGROUND: Early recognition of dietary allergies in infants with atopic dermatitis is essential for avoidance of unnecessary elimination diets, amelioration of the skin disease, and secondary prevention of the development of multiple food allergies. Simple and accurate methods of identifying provocative foods are urgently needed. METHODS: The usefulness of skin prick and patch tests as indicators of cow milk allergy was evaluated in 183 patients ranging in age from 2 to 36 months with double-blind, placebo-controlled (n = 118) or open (n = 65) cow milk challenges. RESULTS: The oral cow milk challenges were interpreted as positive in 54% of both challenge types. Positive challenge rapidly elicited pruritus, urticaria, and/or exanthema in 49% of cases and delayed-onset eczematous lesions in 51%. The skin prick and patch tests gave markedly discrepant results; prick tests were positive in 67% of the cases with acute-onset reactions to milk challenge, whereas patch tests tended to be negative. Patch tests were positive in 89% of those with delayed-onset reactions, although prick tests were frequently negative. CONCLUSIONS: The observations indicate that IgE and T cell-mediated responses to cow milk can be distinguished in atopic dermatitis. Parallel skin testing with combined prick and patch tests can significantly enhance the accuracy in diagnosis of specific dietary allergies in patients with atopic dermatitis. SN - 0091-6749 UR - https://www.unboundmedicine.com/medline/citation/8568142/Combined_skin_prick_and_patch_testing_enhances_identification_of_food_allergy_in_infants_with_atopic_dermatitis_ L2 - https://linkinghub.elsevier.com/retrieve/pii/S0091-6749(96)70277-4 DB - PRIME DP - Unbound Medicine ER -