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Cerebrospinal fluid antibodies detected by ELISA against a 33-kDa antigen from spherules of Coccidioides immitis in patients with coccidioidal meningitis. The National Institute of Allergy and Infectious Diseases Mycoses Study Group.
J Infect Dis. 1996 Feb; 173(2):499-502.JI

Abstract

Antibodies against a 33-kDa antigen from Coccidioides immitis were detected by ELISA in patients' cerebrospinal fluid (CSF). Anti-33-kDa antibodies were detected at dilutions > 1:80 in only 1 (1.4%) of 73 patients without coccidioidal meningitis but in 74 (71.8%) of 103 with meningitis. Anti-33-kDa antibodies were detected in 53 (91.4%) of 58 patients whose anti-coccidioidal complement-fixing (CF) antibodies were detectable and in 21 (46.7%) of 45 patients whose CSF was negative by CF test (positive predictive value, 99%; negative predictive value, 71%; sensitivity, 72%; specificity, 99%). Anti-33-kDa antibodies, among which IgG1 was the dominant subclass, increased when infections worsened and decreased when patients' conditions improved. Antibody concentration appeared to be independent of most baseline findings, although only 1 of 5 patients coinfected with human immunodeficiency virus had initially detectable antibodies. Measurement of anti-33-kDa antibodies is a sensitive indicator of coccidioidal meningitis and of its clinical course.

Authors+Show Affiliations

Medical Service, VA Medical Center, Tucson, AZ 85723, USA.No affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Journal Article
Research Support, Non-U.S. Gov't
Research Support, U.S. Gov't, Non-P.H.S.
Research Support, U.S. Gov't, P.H.S.

Language

eng

PubMed ID

8568322

Citation

Galgiani, J N., et al. "Cerebrospinal Fluid Antibodies Detected By ELISA Against a 33-kDa Antigen From Spherules of Coccidioides Immitis in Patients With Coccidioidal Meningitis. the National Institute of Allergy and Infectious Diseases Mycoses Study Group." The Journal of Infectious Diseases, vol. 173, no. 2, 1996, pp. 499-502.
Galgiani JN, Peng T, Lewis ML, et al. Cerebrospinal fluid antibodies detected by ELISA against a 33-kDa antigen from spherules of Coccidioides immitis in patients with coccidioidal meningitis. The National Institute of Allergy and Infectious Diseases Mycoses Study Group. J Infect Dis. 1996;173(2):499-502.
Galgiani, J. N., Peng, T., Lewis, M. L., Cloud, G. A., & Pappagianis, D. (1996). Cerebrospinal fluid antibodies detected by ELISA against a 33-kDa antigen from spherules of Coccidioides immitis in patients with coccidioidal meningitis. The National Institute of Allergy and Infectious Diseases Mycoses Study Group. The Journal of Infectious Diseases, 173(2), 499-502.
Galgiani JN, et al. Cerebrospinal Fluid Antibodies Detected By ELISA Against a 33-kDa Antigen From Spherules of Coccidioides Immitis in Patients With Coccidioidal Meningitis. the National Institute of Allergy and Infectious Diseases Mycoses Study Group. J Infect Dis. 1996;173(2):499-502. PubMed PMID: 8568322.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Cerebrospinal fluid antibodies detected by ELISA against a 33-kDa antigen from spherules of Coccidioides immitis in patients with coccidioidal meningitis. The National Institute of Allergy and Infectious Diseases Mycoses Study Group. AU - Galgiani,J N, AU - Peng,T, AU - Lewis,M L, AU - Cloud,G A, AU - Pappagianis,D, PY - 1996/2/1/pubmed PY - 1996/2/1/medline PY - 1996/2/1/entrez SP - 499 EP - 502 JF - The Journal of infectious diseases JO - J Infect Dis VL - 173 IS - 2 N2 - Antibodies against a 33-kDa antigen from Coccidioides immitis were detected by ELISA in patients' cerebrospinal fluid (CSF). Anti-33-kDa antibodies were detected at dilutions > 1:80 in only 1 (1.4%) of 73 patients without coccidioidal meningitis but in 74 (71.8%) of 103 with meningitis. Anti-33-kDa antibodies were detected in 53 (91.4%) of 58 patients whose anti-coccidioidal complement-fixing (CF) antibodies were detectable and in 21 (46.7%) of 45 patients whose CSF was negative by CF test (positive predictive value, 99%; negative predictive value, 71%; sensitivity, 72%; specificity, 99%). Anti-33-kDa antibodies, among which IgG1 was the dominant subclass, increased when infections worsened and decreased when patients' conditions improved. Antibody concentration appeared to be independent of most baseline findings, although only 1 of 5 patients coinfected with human immunodeficiency virus had initially detectable antibodies. Measurement of anti-33-kDa antibodies is a sensitive indicator of coccidioidal meningitis and of its clinical course. SN - 0022-1899 UR - https://www.unboundmedicine.com/medline/citation/8568322/Cerebrospinal_fluid_antibodies_detected_by_ELISA_against_a_33_kDa_antigen_from_spherules_of_Coccidioides_immitis_in_patients_with_coccidioidal_meningitis__The_National_Institute_of_Allergy_and_Infectious_Diseases_Mycoses_Study_Group_ L2 - https://academic.oup.com/jid/article-lookup/doi/10.1093/infdis/173.2.499 DB - PRIME DP - Unbound Medicine ER -