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[Estimation of anti-thyroid peroxidase autoantibody (TPOAb) and anti-thyroglobulin autoantibody (TgAb) in patients with various thyroid disease--comparison between histopathological findings and serological results in patients with Hashimoto's thyroiditis].
Rinsho Byori 1995; 43(12):1243-50RB

Abstract

We compared and evaluated titers of AMC (anti-microsome antibody), and ATG (anti-thyroglobulin antibody) by passive gelatin-agglutination and by radioimmunoassay in 170 sera from 129 patients with various thyroid diseases and 41 normal subjects. The results of conventional ATG and TgAb by RIA correlated (r = 0.731) and those of conventional AMC and TPOAb correlated well (r = 0.907), with discrepancies mostly limited to sera with low antibody titers. Five patients with Hashimoto's thyroiditis showed positive results in AMC, whilst negative in TPOAb. These sera had positive ATG autoantibody and preincubation with thyroglobulin inhibited the agglutination reaction of AMC tests, suggesting ATG producing false positive results in AMC assay. The prevalences of positive TgAb rates were higher than (p < 0.001) ATG in patients with Hashimoto's disease (96.6% vs 50.0%) and Graves' disease (76.9% vs 46.1%). However, the prevalences of positive TPOAb were not different from AMC (Hashimoto's disease 75.9% vs 81.0%: Graves' disease 80.8% vs 76.9%). In patients with Hashimoto's thyroiditis, our study demonstrates the results of TgAb by RIA reflects the pathological findings and the diagnostic sensitivity increases by using in combination with TPOAb.

Authors+Show Affiliations

Central Clinical Laboratory, Kanazawa University Hospital.No affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Comparative Study
English Abstract
Journal Article

Language

jpn

PubMed ID

8569035

Citation

Senda, Y, et al. "[Estimation of Anti-thyroid Peroxidase Autoantibody (TPOAb) and Anti-thyroglobulin Autoantibody (TgAb) in Patients With Various Thyroid Disease--comparison Between Histopathological Findings and Serological Results in Patients With Hashimoto's Thyroiditis]." Rinsho Byori. the Japanese Journal of Clinical Pathology, vol. 43, no. 12, 1995, pp. 1243-50.
Senda Y, Nishibu M, Kawai K, et al. [Estimation of anti-thyroid peroxidase autoantibody (TPOAb) and anti-thyroglobulin autoantibody (TgAb) in patients with various thyroid disease--comparison between histopathological findings and serological results in patients with Hashimoto's thyroiditis]. Rinsho Byori. 1995;43(12):1243-50.
Senda, Y., Nishibu, M., Kawai, K., Mizukami, Y., & Hashimoto, T. (1995). [Estimation of anti-thyroid peroxidase autoantibody (TPOAb) and anti-thyroglobulin autoantibody (TgAb) in patients with various thyroid disease--comparison between histopathological findings and serological results in patients with Hashimoto's thyroiditis]. Rinsho Byori. the Japanese Journal of Clinical Pathology, 43(12), pp. 1243-50.
Senda Y, et al. [Estimation of Anti-thyroid Peroxidase Autoantibody (TPOAb) and Anti-thyroglobulin Autoantibody (TgAb) in Patients With Various Thyroid Disease--comparison Between Histopathological Findings and Serological Results in Patients With Hashimoto's Thyroiditis]. Rinsho Byori. 1995;43(12):1243-50. PubMed PMID: 8569035.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - [Estimation of anti-thyroid peroxidase autoantibody (TPOAb) and anti-thyroglobulin autoantibody (TgAb) in patients with various thyroid disease--comparison between histopathological findings and serological results in patients with Hashimoto's thyroiditis]. AU - Senda,Y, AU - Nishibu,M, AU - Kawai,K, AU - Mizukami,Y, AU - Hashimoto,T, PY - 1995/12/1/pubmed PY - 1995/12/1/medline PY - 1995/12/1/entrez SP - 1243 EP - 50 JF - Rinsho byori. The Japanese journal of clinical pathology JO - Rinsho Byori VL - 43 IS - 12 N2 - We compared and evaluated titers of AMC (anti-microsome antibody), and ATG (anti-thyroglobulin antibody) by passive gelatin-agglutination and by radioimmunoassay in 170 sera from 129 patients with various thyroid diseases and 41 normal subjects. The results of conventional ATG and TgAb by RIA correlated (r = 0.731) and those of conventional AMC and TPOAb correlated well (r = 0.907), with discrepancies mostly limited to sera with low antibody titers. Five patients with Hashimoto's thyroiditis showed positive results in AMC, whilst negative in TPOAb. These sera had positive ATG autoantibody and preincubation with thyroglobulin inhibited the agglutination reaction of AMC tests, suggesting ATG producing false positive results in AMC assay. The prevalences of positive TgAb rates were higher than (p < 0.001) ATG in patients with Hashimoto's disease (96.6% vs 50.0%) and Graves' disease (76.9% vs 46.1%). However, the prevalences of positive TPOAb were not different from AMC (Hashimoto's disease 75.9% vs 81.0%: Graves' disease 80.8% vs 76.9%). In patients with Hashimoto's thyroiditis, our study demonstrates the results of TgAb by RIA reflects the pathological findings and the diagnostic sensitivity increases by using in combination with TPOAb. SN - 0047-1860 UR - https://www.unboundmedicine.com/medline/citation/8569035/[Estimation_of_anti_thyroid_peroxidase_autoantibody__TPOAb__and_anti_thyroglobulin_autoantibody__TgAb__in_patients_with_various_thyroid_disease__comparison_between_histopathological_findings_and_serological_results_in_patients_with_Hashimoto's_thyroiditis]_ L2 - http://www.diseaseinfosearch.org/result/3247 DB - PRIME DP - Unbound Medicine ER -