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Drug-induced modifications of the immune response. 1. Substituted 1-phenylisoquinolines.
J Med Chem. 1979 Apr; 22(4):348-52.JM

Abstract

A series of 1-phenylisoquinolines and related compounds was prepared and tested for potential antiallergic activity. Several compounds of this series inhibited the antigen-induced wheal formation in rat passive cutaneous anaphylaxis (PCA) assay, a commonly used test for antiallergic activity. Many of these compounds also inhibited the antigen-induced histamine release from passively sensitized guinea pig lung slices. Furthermore, almost all of these derivatives inhibited the cyclic nucleotide phosphodiesterase, suggesting this as one of several possible mechanisms of action.

Authors

St Georgiev V
No affiliation info available
Carlson RP
No affiliation info available
Van Inwegen RG
No affiliation info available
Khandwala A
No affiliation info available

MeSH

3',5'-Cyclic-AMP PhosphodiesterasesAnimalsDogsGuinea PigsHistamine ReleaseHypersensitivityIn Vitro TechniquesIsoquinolinesLungMalePassive Cutaneous AnaphylaxisRatsSerotonin AntagonistsSkin Tests

Pub Type(s)

Journal Article

Language

eng

PubMed ID

85712

Citation

St Georgiev, V, et al. "Drug-induced Modifications of the Immune Response. 1. Substituted 1-phenylisoquinolines." Journal of Medicinal Chemistry, vol. 22, no. 4, 1979, pp. 348-52.
St Georgiev V, Carlson RP, Van Inwegen RG, et al. Drug-induced modifications of the immune response. 1. Substituted 1-phenylisoquinolines. J Med Chem. 1979;22(4):348-52.
St Georgiev, V., Carlson, R. P., Van Inwegen, R. G., & Khandwala, A. (1979). Drug-induced modifications of the immune response. 1. Substituted 1-phenylisoquinolines. Journal of Medicinal Chemistry, 22(4), 348-52.
St Georgiev V, et al. Drug-induced Modifications of the Immune Response. 1. Substituted 1-phenylisoquinolines. J Med Chem. 1979;22(4):348-52. PubMed PMID: 85712.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Drug-induced modifications of the immune response. 1. Substituted 1-phenylisoquinolines. AU - St Georgiev,V, AU - Carlson,R P, AU - Van Inwegen,R G, AU - Khandwala,A, PY - 1979/4/1/pubmed PY - 1979/4/1/medline PY - 1979/4/1/entrez SP - 348 EP - 52 JF - Journal of medicinal chemistry JO - J Med Chem VL - 22 IS - 4 N2 - A series of 1-phenylisoquinolines and related compounds was prepared and tested for potential antiallergic activity. Several compounds of this series inhibited the antigen-induced wheal formation in rat passive cutaneous anaphylaxis (PCA) assay, a commonly used test for antiallergic activity. Many of these compounds also inhibited the antigen-induced histamine release from passively sensitized guinea pig lung slices. Furthermore, almost all of these derivatives inhibited the cyclic nucleotide phosphodiesterase, suggesting this as one of several possible mechanisms of action. SN - 0022-2623 UR - https://www.unboundmedicine.com/medline/citation/85712/Drug_induced_modifications_of_the_immune_response__1__Substituted_1_phenylisoquinolines_ DB - PRIME DP - Unbound Medicine ER -