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Changes in haemostatic variables induced by oral contraceptives containing 50 micrograms or 30 micrograms oestrogen: absence of dose-dependent effect on PAI-1 activity.
Thromb Haemost. 1995 Sep; 74(3):928-32.TH

Abstract

Several studies have suggested a dose-response relation between the oestrogen content of oral contraceptive (OC) and the risk of both venous thrombosis and arterial disease, when oestrogen doses were higher than 50 micrograms. However, there is no clear epidemiological evidence for a decrease in thrombotic risk with formulations containing less than 50 micrograms oestrogen. Therefore, we investigated haemostatic variables in users of OC containing either 30 micrograms (35 women) or 50 micrograms (29 women) ethinyl estradiol as compared with non users (64 women) matched for age and smoking status. Mean values of antithrombin activity were significantly lower in 30 micrograms or 50 micrograms oestrogen users than in non users (96% and 98% vs 105%, respectively, p < 0.001), but they were not significantly different between the two groups of OC users. There was a significant increase in mean values of factor VII antigen in women taking either 30 micrograms or 50 micrograms oestrogen as compared with non users (96% and 101% vs 85%, respectively, p < 0.005). Although the difference between both groups of OC users was not significant, a positive linear trend in factor VII levels was observed within the 0-50 micrograms oestrogen range (p < 0.001). Mean levels of fibrinogen were slightly higher in 30 micrograms or 50 micrograms oestrogen users than in non users (2.71, 2.66 g/l vs 2.55 g/l, respectively), but there was no significant difference between the three groups.(

ABSTRACT

TRUNCATED AT 250 WORDS)

Authors+Show Affiliations

INSERM, Cardiovascular Epidemiology Unit U 258, Hôpital Broussais, France.No affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Comparative Study
Journal Article

Language

eng

PubMed ID

8571323

Citation

Scarabin, P Y., et al. "Changes in Haemostatic Variables Induced By Oral Contraceptives Containing 50 Micrograms or 30 Micrograms Oestrogen: Absence of Dose-dependent Effect On PAI-1 Activity." Thrombosis and Haemostasis, vol. 74, no. 3, 1995, pp. 928-32.
Scarabin PY, Plu-Bureau G, Zitoun D, et al. Changes in haemostatic variables induced by oral contraceptives containing 50 micrograms or 30 micrograms oestrogen: absence of dose-dependent effect on PAI-1 activity. Thromb Haemost. 1995;74(3):928-32.
Scarabin, P. Y., Plu-Bureau, G., Zitoun, D., Bara, L., Guize, L., & Samama, M. M. (1995). Changes in haemostatic variables induced by oral contraceptives containing 50 micrograms or 30 micrograms oestrogen: absence of dose-dependent effect on PAI-1 activity. Thrombosis and Haemostasis, 74(3), 928-32.
Scarabin PY, et al. Changes in Haemostatic Variables Induced By Oral Contraceptives Containing 50 Micrograms or 30 Micrograms Oestrogen: Absence of Dose-dependent Effect On PAI-1 Activity. Thromb Haemost. 1995;74(3):928-32. PubMed PMID: 8571323.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Changes in haemostatic variables induced by oral contraceptives containing 50 micrograms or 30 micrograms oestrogen: absence of dose-dependent effect on PAI-1 activity. AU - Scarabin,P Y, AU - Plu-Bureau,G, AU - Zitoun,D, AU - Bara,L, AU - Guize,L, AU - Samama,M M, PY - 1995/9/1/pubmed PY - 1995/9/1/medline PY - 1995/9/1/entrez KW - Biology KW - Blood Coagulation Effects KW - Case Control Studies KW - Clinical Research KW - Contraception KW - Contraceptive Agents, Estrogen--administraction and dosage KW - Contraceptive Agents, Female--administraction and dosage KW - Contraceptive Agents, Progestin--administraction and dosage KW - Contraceptive Agents--administraction and dosage KW - Contraceptive Methods KW - Developed Countries KW - Diseases KW - Embolism KW - Ethinyl Estradiol--administraction and dosage KW - Europe KW - Family Planning KW - Fibrinolysis KW - France KW - Hematological Effects KW - Hemic System KW - Levonorgestrel--administraction and dosage KW - Mediterranean Countries KW - Oral Contraceptives KW - Oral Contraceptives, Combined KW - Physiology KW - Research Methodology KW - Research Report KW - Studies KW - Thromboembolism KW - Thrombosis KW - Vascular Diseases KW - Western Europe SP - 928 EP - 32 JF - Thrombosis and haemostasis JO - Thromb Haemost VL - 74 IS - 3 N2 - Several studies have suggested a dose-response relation between the oestrogen content of oral contraceptive (OC) and the risk of both venous thrombosis and arterial disease, when oestrogen doses were higher than 50 micrograms. However, there is no clear epidemiological evidence for a decrease in thrombotic risk with formulations containing less than 50 micrograms oestrogen. Therefore, we investigated haemostatic variables in users of OC containing either 30 micrograms (35 women) or 50 micrograms (29 women) ethinyl estradiol as compared with non users (64 women) matched for age and smoking status. Mean values of antithrombin activity were significantly lower in 30 micrograms or 50 micrograms oestrogen users than in non users (96% and 98% vs 105%, respectively, p < 0.001), but they were not significantly different between the two groups of OC users. There was a significant increase in mean values of factor VII antigen in women taking either 30 micrograms or 50 micrograms oestrogen as compared with non users (96% and 101% vs 85%, respectively, p < 0.005). Although the difference between both groups of OC users was not significant, a positive linear trend in factor VII levels was observed within the 0-50 micrograms oestrogen range (p < 0.001). Mean levels of fibrinogen were slightly higher in 30 micrograms or 50 micrograms oestrogen users than in non users (2.71, 2.66 g/l vs 2.55 g/l, respectively), but there was no significant difference between the three groups.(ABSTRACT TRUNCATED AT 250 WORDS) SN - 0340-6245 UR - https://www.unboundmedicine.com/medline/citation/8571323/Changes_in_haemostatic_variables_induced_by_oral_contraceptives_containing_50_micrograms_or_30_micrograms_oestrogen:_absence_of_dose_dependent_effect_on_PAI_1_activity_ DB - PRIME DP - Unbound Medicine ER -