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In vitro reactivity to a protein-bound polysaccharide PSK of peripheral blood lymphocytes from patients with gastrointestinal cancer.
Anticancer Res. 1995 Sep-Oct; 15(5B):2175-9.AR

Abstract

The effect of PSK, a protein-bound polysaccharide and an immunomodulator, on lymphocytes was examined in vitro for 36 patients with gastric cancer and 26 with colorectal cancer. Cultured lymphocytes with PSK at 100 micrograms/ml increased the level of DNA synthesis, as determined by the 3H-thymidine uptake, from 0.9 to 3.0 fold, compared to the PSK non-treated cells. The increase was 1.36 +/- 0.46 fold for the gastric cancer cases and 1.37 + 0.45 fold for the colorectal cancer cases, and these levels were significantly the finding of 1.93 + 0.55 fold for a control group consisting of 15 healthy volunteers (P < 0.01). When the 1.3 fold increase of 3H-thymidine uptake was defined as the PSK-reactive group, 52.8% (19/36) of the patients with gastric cancer and 50.0% (13/26) for colorectal cancer were found in the PSK-reactive group. The PSK-reactive group demonstrated no relation to the age and sex of the patients, tissue differentiation type or tumor advancement. Our findings thus show that the in vitro activation of lymphocytes by PSK can help identify the candidates with either gastric or colorectal cancer who are the best suited to undergo immunochemotherapy including treatment with PSK.

Authors+Show Affiliations

Sugimachi K
Department of Surgery II, Faculty of Medicine, Kyushu University, Fukuoka, Japan.
Maehara Y
No affiliation info available
Kusumoto T
No affiliation info available
Okamura T
No affiliation info available
Korenaga D
No affiliation info available
Kohnoe S
No affiliation info available
Baba H
No affiliation info available
Anai H
No affiliation info available

MeSH

Adjuvants, ImmunologicAdultColorectal NeoplasmsDNAFemaleHumansIn Vitro TechniquesLymphocyte ActivationMaleMiddle AgedProteoglycansStomach Neoplasms

Pub Type(s)

Journal Article

Language

eng

PubMed ID

8572620

Citation

Sugimachi, K, et al. "In Vitro Reactivity to a Protein-bound Polysaccharide PSK of Peripheral Blood Lymphocytes From Patients With Gastrointestinal Cancer." Anticancer Research, vol. 15, no. 5B, 1995, pp. 2175-9.
Sugimachi K, Maehara Y, Kusumoto T, et al. In vitro reactivity to a protein-bound polysaccharide PSK of peripheral blood lymphocytes from patients with gastrointestinal cancer. Anticancer Res. 1995;15(5B):2175-9.
Sugimachi, K., Maehara, Y., Kusumoto, T., Okamura, T., Korenaga, D., Kohnoe, S., Baba, H., & Anai, H. (1995). In vitro reactivity to a protein-bound polysaccharide PSK of peripheral blood lymphocytes from patients with gastrointestinal cancer. Anticancer Research, 15(5B), 2175-9.
Sugimachi K, et al. In Vitro Reactivity to a Protein-bound Polysaccharide PSK of Peripheral Blood Lymphocytes From Patients With Gastrointestinal Cancer. Anticancer Res. 1995 Sep-Oct;15(5B):2175-9. PubMed PMID: 8572620.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - In vitro reactivity to a protein-bound polysaccharide PSK of peripheral blood lymphocytes from patients with gastrointestinal cancer. AU - Sugimachi,K, AU - Maehara,Y, AU - Kusumoto,T, AU - Okamura,T, AU - Korenaga,D, AU - Kohnoe,S, AU - Baba,H, AU - Anai,H, PY - 1995/9/1/pubmed PY - 1995/9/1/medline PY - 1995/9/1/entrez SP - 2175 EP - 9 JF - Anticancer research JO - Anticancer Res VL - 15 IS - 5B N2 - The effect of PSK, a protein-bound polysaccharide and an immunomodulator, on lymphocytes was examined in vitro for 36 patients with gastric cancer and 26 with colorectal cancer. Cultured lymphocytes with PSK at 100 micrograms/ml increased the level of DNA synthesis, as determined by the 3H-thymidine uptake, from 0.9 to 3.0 fold, compared to the PSK non-treated cells. The increase was 1.36 +/- 0.46 fold for the gastric cancer cases and 1.37 + 0.45 fold for the colorectal cancer cases, and these levels were significantly the finding of 1.93 + 0.55 fold for a control group consisting of 15 healthy volunteers (P < 0.01). When the 1.3 fold increase of 3H-thymidine uptake was defined as the PSK-reactive group, 52.8% (19/36) of the patients with gastric cancer and 50.0% (13/26) for colorectal cancer were found in the PSK-reactive group. The PSK-reactive group demonstrated no relation to the age and sex of the patients, tissue differentiation type or tumor advancement. Our findings thus show that the in vitro activation of lymphocytes by PSK can help identify the candidates with either gastric or colorectal cancer who are the best suited to undergo immunochemotherapy including treatment with PSK. SN - 0250-7005 UR - https://www.unboundmedicine.com/medline/citation/8572620/In_vitro_reactivity_to_a_protein_bound_polysaccharide_PSK_of_peripheral_blood_lymphocytes_from_patients_with_gastrointestinal_cancer_ L2 - https://medlineplus.gov/stomachcancer.html DB - PRIME DP - Unbound Medicine ER -