Type your tag names separated by a space and hit enter

Dietary lipids and antioxidants in Parkinson's disease: a population-based, case-control study.

Abstract

Oxidative stress plays an important role in the pathogenesis of Parkinson's disease (PD). In a population-based, case-control study we examined whether dietary intake of antioxidants and other oxidative compounds was associated with PD. Dietary intake was assessed by a semiquantitative food-frequency questionnaire in 110 PD case patients and 287 control subjects. A higher caloric intake was observed in patients with PD and did not vary with increasing duration of symptoms. Energy-adjusted fat intake was significantly higher among patients with PD than control subjects (p for trend = 0.007). Intake of protein (p for trend = 0.17) and carbohydrates (p for trend = 0.46) did not differ in patients and control subjects. Analyses of the primary sources of fat indicated that increasing intake of animal fats were strongly related to PD (odds ratio, 5.3; 95% confidence interval, 1.8-15.5; p for trend = 0.001). No significant differences were observed for intake of vitamins with antioxidant activity. An increase in the consumption of animal fats among patients with PD is consistent with the hypothesis that oxidative stress and lipid peroxidation are important in the pathogenesis of this disease. No effect of vitamins with antioxidant activity, either from food or supplements, was observed.

Links

  • Publisher Full Text
  • Authors+Show Affiliations

    ,

    Gertrude H. Sergievsky Center, New York, NY 10032, USA.

    , , , ,

    Source

    Annals of neurology 39:1 1996 Jan pg 89-94

    MeSH

    Aged
    Aged, 80 and over
    Antioxidants
    Ascorbic Acid
    Case-Control Studies
    Diet Surveys
    Dietary Carbohydrates
    Dietary Fats
    Dietary Proteins
    Energy Intake
    Female
    Humans
    Lipid Peroxidation
    Male
    Odds Ratio
    Parkinson Disease
    Vitamin A
    Vitamin E
    Vitamins

    Pub Type(s)

    Journal Article
    Research Support, Non-U.S. Gov't
    Research Support, U.S. Gov't, P.H.S.

    Language

    eng

    PubMed ID

    8572672

    Citation

    Logroscino, G, et al. "Dietary Lipids and Antioxidants in Parkinson's Disease: a Population-based, Case-control Study." Annals of Neurology, vol. 39, no. 1, 1996, pp. 89-94.
    Logroscino G, Marder K, Cote L, et al. Dietary lipids and antioxidants in Parkinson's disease: a population-based, case-control study. Ann Neurol. 1996;39(1):89-94.
    Logroscino, G., Marder, K., Cote, L., Tang, M. X., Shea, S., & Mayeux, R. (1996). Dietary lipids and antioxidants in Parkinson's disease: a population-based, case-control study. Annals of Neurology, 39(1), pp. 89-94.
    Logroscino G, et al. Dietary Lipids and Antioxidants in Parkinson's Disease: a Population-based, Case-control Study. Ann Neurol. 1996;39(1):89-94. PubMed PMID: 8572672.
    * Article titles in AMA citation format should be in sentence-case
    TY - JOUR T1 - Dietary lipids and antioxidants in Parkinson's disease: a population-based, case-control study. AU - Logroscino,G, AU - Marder,K, AU - Cote,L, AU - Tang,M X, AU - Shea,S, AU - Mayeux,R, PY - 1996/1/1/pubmed PY - 1996/1/1/medline PY - 1996/1/1/entrez SP - 89 EP - 94 JF - Annals of neurology JO - Ann. Neurol. VL - 39 IS - 1 N2 - Oxidative stress plays an important role in the pathogenesis of Parkinson's disease (PD). In a population-based, case-control study we examined whether dietary intake of antioxidants and other oxidative compounds was associated with PD. Dietary intake was assessed by a semiquantitative food-frequency questionnaire in 110 PD case patients and 287 control subjects. A higher caloric intake was observed in patients with PD and did not vary with increasing duration of symptoms. Energy-adjusted fat intake was significantly higher among patients with PD than control subjects (p for trend = 0.007). Intake of protein (p for trend = 0.17) and carbohydrates (p for trend = 0.46) did not differ in patients and control subjects. Analyses of the primary sources of fat indicated that increasing intake of animal fats were strongly related to PD (odds ratio, 5.3; 95% confidence interval, 1.8-15.5; p for trend = 0.001). No significant differences were observed for intake of vitamins with antioxidant activity. An increase in the consumption of animal fats among patients with PD is consistent with the hypothesis that oxidative stress and lipid peroxidation are important in the pathogenesis of this disease. No effect of vitamins with antioxidant activity, either from food or supplements, was observed. SN - 0364-5134 UR - https://www.unboundmedicine.com/medline/citation/8572672/full_citation L2 - https://onlinelibrary.wiley.com/resolve/openurl?genre=article&sid=nlm:pubmed&issn=0364-5134&date=1996&volume=39&issue=1&spage=89 DB - PRIME DP - Unbound Medicine ER -