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Development of IgG subclasses in healthy Polish children.
Arch Immunol Ther Exp (Warsz). 1994; 42(5-6):377-82.AI

Abstract

To determine the ontogeny of IgG subclasses in healthy Polish children IgG1, IgG2, IgG3, IgG4 concentrations were measured by enzyme-linked immunosorbent assay in 30 cord blood sera and sera from 152 healthy children aged 4 months to 16 years. The geometric mean of concentrations all of IgG subclasses in age-related groups of children were calculated. In cord sera, four IgG subclasses were found with the IgG1 level reaching about 90%, IgG2--52%, IgG3--80% and IgG4--33% of the mean adult values. In the group of youngest children (4-6 months of age) the concentration of all IgG subclasses were significantly decreased in comparison to initial values. Then, IgG1 and IgG3 levels increased rapidly reaching ca. 50% of the mean adult values by 1 year of age. We also demonstrated much slower maturation of IgG2 and IgG4 which lagged behind IgG1 and IgG3 development, especially in younger children.

Authors+Show Affiliations

Department of Immunology, Child Health Center, Warsaw, Poland.No affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Journal Article
Research Support, Non-U.S. Gov't

Language

eng

PubMed ID

8572895

Citation

Gregorek, H, et al. "Development of IgG Subclasses in Healthy Polish Children." Archivum Immunologiae Et Therapiae Experimentalis, vol. 42, no. 5-6, 1994, pp. 377-82.
Gregorek H, Imielska D, Gornicki J, et al. Development of IgG subclasses in healthy Polish children. Arch Immunol Ther Exp (Warsz). 1994;42(5-6):377-82.
Gregorek, H., Imielska, D., Gornicki, J., Mikołajewicz, J., Przeradzka, B., & Madaliński, K. (1994). Development of IgG subclasses in healthy Polish children. Archivum Immunologiae Et Therapiae Experimentalis, 42(5-6), 377-82.
Gregorek H, et al. Development of IgG Subclasses in Healthy Polish Children. Arch Immunol Ther Exp (Warsz). 1994;42(5-6):377-82. PubMed PMID: 8572895.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Development of IgG subclasses in healthy Polish children. AU - Gregorek,H, AU - Imielska,D, AU - Gornicki,J, AU - Mikołajewicz,J, AU - Przeradzka,B, AU - Madaliński,K, PY - 1994/1/1/pubmed PY - 1994/1/1/medline PY - 1994/1/1/entrez SP - 377 EP - 82 JF - Archivum immunologiae et therapiae experimentalis JO - Arch. Immunol. Ther. Exp. (Warsz.) VL - 42 IS - 5-6 N2 - To determine the ontogeny of IgG subclasses in healthy Polish children IgG1, IgG2, IgG3, IgG4 concentrations were measured by enzyme-linked immunosorbent assay in 30 cord blood sera and sera from 152 healthy children aged 4 months to 16 years. The geometric mean of concentrations all of IgG subclasses in age-related groups of children were calculated. In cord sera, four IgG subclasses were found with the IgG1 level reaching about 90%, IgG2--52%, IgG3--80% and IgG4--33% of the mean adult values. In the group of youngest children (4-6 months of age) the concentration of all IgG subclasses were significantly decreased in comparison to initial values. Then, IgG1 and IgG3 levels increased rapidly reaching ca. 50% of the mean adult values by 1 year of age. We also demonstrated much slower maturation of IgG2 and IgG4 which lagged behind IgG1 and IgG3 development, especially in younger children. SN - 0004-069X UR - https://www.unboundmedicine.com/medline/citation/8572895/Development_of_IgG_subclasses_in_healthy_Polish_children_ L2 - https://medlineplus.gov/olderadulthealth.html DB - PRIME DP - Unbound Medicine ER -