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Combination of ranitidine and cisapride in the treatment of reflux oesophagitis.
Eur J Gastroenterol Hepatol 1995; 7(9):817-22EJ

Abstract

OBJECTIVE

To compare the efficacy of treatment for 8 or 12 weeks with a combination of 150 mg ranitidine twice daily plus 20 mg cisapride twice daily with ranitidine 150 mg twice daily alone in patients with moderate-to-severe reflux oesophagitis.

DESIGN

A double-blind, randomized, parallel-group clinical trial.

SETTING

Forty-two out-patient centres in the UK, Germany, Ireland, Denmark and South Africa.

PATIENTS

A total of 344 symptomatic patients with endoscopically confirmed reflux oesophagitis (Hetzel grade 3 or 4) were randomly assigned to receive the study medication.

INTERVENTIONS

Patients underwent a follow-up endoscopy after 8 weeks' treatment. Healing was defined as Hetzel grade 0 or 1 upon endoscopy. Patients with unhealed oesophagitis continued their allocated treatment regimen for a further 4 weeks before undergoing a repeat endoscopy.

MAIN OUTCOME MEASURES

The primary efficacy analysis was based on a comparison of 12-week cumulative healing rates between the two groups.

RESULTS

A statistically significant difference (P = 0.015) in the cumulative healing rate was observed between patients given ranitidine plus cisapride (82%) and those given ranitidine alone (71%). Oesophagitis in patients who received the combination was twice as likely to heal as that in patients who received ranitidine alone.

CONCLUSION

A combination of 150 mg ranitidine twice daily and 20 mg cisapride twice daily is a safe and effective treatment for moderate-to-severe reflux oesophagitis and offers increased efficacy over ranitidine alone.

Authors+Show Affiliations

Department of Gastroenterology, Glaxo Research and Development Ltd, Uxbridge, Middlesex, UK.No affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Clinical Trial
Journal Article
Multicenter Study
Randomized Controlled Trial
Research Support, Non-U.S. Gov't

Language

eng

PubMed ID

8574711

Citation

McKenna, C J., et al. "Combination of Ranitidine and Cisapride in the Treatment of Reflux Oesophagitis." European Journal of Gastroenterology & Hepatology, vol. 7, no. 9, 1995, pp. 817-22.
McKenna CJ, Mills JG, Goodwin C, et al. Combination of ranitidine and cisapride in the treatment of reflux oesophagitis. Eur J Gastroenterol Hepatol. 1995;7(9):817-22.
McKenna, C. J., Mills, J. G., Goodwin, C., & Wood, J. R. (1995). Combination of ranitidine and cisapride in the treatment of reflux oesophagitis. European Journal of Gastroenterology & Hepatology, 7(9), pp. 817-22.
McKenna CJ, et al. Combination of Ranitidine and Cisapride in the Treatment of Reflux Oesophagitis. Eur J Gastroenterol Hepatol. 1995;7(9):817-22. PubMed PMID: 8574711.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Combination of ranitidine and cisapride in the treatment of reflux oesophagitis. AU - McKenna,C J, AU - Mills,J G, AU - Goodwin,C, AU - Wood,J R, PY - 1995/9/1/pubmed PY - 1995/9/1/medline PY - 1995/9/1/entrez SP - 817 EP - 22 JF - European journal of gastroenterology & hepatology JO - Eur J Gastroenterol Hepatol VL - 7 IS - 9 N2 - OBJECTIVE: To compare the efficacy of treatment for 8 or 12 weeks with a combination of 150 mg ranitidine twice daily plus 20 mg cisapride twice daily with ranitidine 150 mg twice daily alone in patients with moderate-to-severe reflux oesophagitis. DESIGN: A double-blind, randomized, parallel-group clinical trial. SETTING: Forty-two out-patient centres in the UK, Germany, Ireland, Denmark and South Africa. PATIENTS: A total of 344 symptomatic patients with endoscopically confirmed reflux oesophagitis (Hetzel grade 3 or 4) were randomly assigned to receive the study medication. INTERVENTIONS: Patients underwent a follow-up endoscopy after 8 weeks' treatment. Healing was defined as Hetzel grade 0 or 1 upon endoscopy. Patients with unhealed oesophagitis continued their allocated treatment regimen for a further 4 weeks before undergoing a repeat endoscopy. MAIN OUTCOME MEASURES: The primary efficacy analysis was based on a comparison of 12-week cumulative healing rates between the two groups. RESULTS: A statistically significant difference (P = 0.015) in the cumulative healing rate was observed between patients given ranitidine plus cisapride (82%) and those given ranitidine alone (71%). Oesophagitis in patients who received the combination was twice as likely to heal as that in patients who received ranitidine alone. CONCLUSION: A combination of 150 mg ranitidine twice daily and 20 mg cisapride twice daily is a safe and effective treatment for moderate-to-severe reflux oesophagitis and offers increased efficacy over ranitidine alone. SN - 0954-691X UR - https://www.unboundmedicine.com/medline/citation/8574711/Combination_of_ranitidine_and_cisapride_in_the_treatment_of_reflux_oesophagitis_ L2 - https://www.lens.org/lens/search?q=citation_id:8574711 DB - PRIME DP - Unbound Medicine ER -