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Combination of ranitidine and cisapride in the treatment of reflux oesophagitis.
Eur J Gastroenterol Hepatol 1995; 7(9):817-22EJ

Abstract

OBJECTIVE

To compare the efficacy of treatment for 8 or 12 weeks with a combination of 150 mg ranitidine twice daily plus 20 mg cisapride twice daily with ranitidine 150 mg twice daily alone in patients with moderate-to-severe reflux oesophagitis.

DESIGN

A double-blind, randomized, parallel-group clinical trial.

SETTING

Forty-two out-patient centres in the UK, Germany, Ireland, Denmark and South Africa.

PATIENTS

A total of 344 symptomatic patients with endoscopically confirmed reflux oesophagitis (Hetzel grade 3 or 4) were randomly assigned to receive the study medication.

INTERVENTIONS

Patients underwent a follow-up endoscopy after 8 weeks' treatment. Healing was defined as Hetzel grade 0 or 1 upon endoscopy. Patients with unhealed oesophagitis continued their allocated treatment regimen for a further 4 weeks before undergoing a repeat endoscopy.

MAIN OUTCOME MEASURES

The primary efficacy analysis was based on a comparison of 12-week cumulative healing rates between the two groups.

RESULTS

A statistically significant difference (P = 0.015) in the cumulative healing rate was observed between patients given ranitidine plus cisapride (82%) and those given ranitidine alone (71%). Oesophagitis in patients who received the combination was twice as likely to heal as that in patients who received ranitidine alone.

CONCLUSION

A combination of 150 mg ranitidine twice daily and 20 mg cisapride twice daily is a safe and effective treatment for moderate-to-severe reflux oesophagitis and offers increased efficacy over ranitidine alone.

Authors+Show Affiliations

Department of Gastroenterology, Glaxo Research and Development Ltd, Uxbridge, Middlesex, UK.

Pub Type(s)

Clinical Trial
Journal Article
Multicenter Study
Randomized Controlled Trial
Research Support, Non-U.S. Gov't

Language

eng

PubMed ID

8574711

Citation

McKenna, C J., et al. "Combination of Ranitidine and Cisapride in the Treatment of Reflux Oesophagitis." European Journal of Gastroenterology & Hepatology, vol. 7, no. 9, 1995, pp. 817-22.
McKenna CJ, Mills JG, Goodwin C, et al. Combination of ranitidine and cisapride in the treatment of reflux oesophagitis. Eur J Gastroenterol Hepatol. 1995;7(9):817-22.
McKenna, C. J., Mills, J. G., Goodwin, C., & Wood, J. R. (1995). Combination of ranitidine and cisapride in the treatment of reflux oesophagitis. European Journal of Gastroenterology & Hepatology, 7(9), pp. 817-22.
McKenna CJ, et al. Combination of Ranitidine and Cisapride in the Treatment of Reflux Oesophagitis. Eur J Gastroenterol Hepatol. 1995;7(9):817-22. PubMed PMID: 8574711.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Combination of ranitidine and cisapride in the treatment of reflux oesophagitis. AU - McKenna,C J, AU - Mills,J G, AU - Goodwin,C, AU - Wood,J R, PY - 1995/9/1/pubmed PY - 1995/9/1/medline PY - 1995/9/1/entrez SP - 817 EP - 22 JF - European journal of gastroenterology & hepatology JO - Eur J Gastroenterol Hepatol VL - 7 IS - 9 N2 - OBJECTIVE: To compare the efficacy of treatment for 8 or 12 weeks with a combination of 150 mg ranitidine twice daily plus 20 mg cisapride twice daily with ranitidine 150 mg twice daily alone in patients with moderate-to-severe reflux oesophagitis. DESIGN: A double-blind, randomized, parallel-group clinical trial. SETTING: Forty-two out-patient centres in the UK, Germany, Ireland, Denmark and South Africa. PATIENTS: A total of 344 symptomatic patients with endoscopically confirmed reflux oesophagitis (Hetzel grade 3 or 4) were randomly assigned to receive the study medication. INTERVENTIONS: Patients underwent a follow-up endoscopy after 8 weeks' treatment. Healing was defined as Hetzel grade 0 or 1 upon endoscopy. Patients with unhealed oesophagitis continued their allocated treatment regimen for a further 4 weeks before undergoing a repeat endoscopy. MAIN OUTCOME MEASURES: The primary efficacy analysis was based on a comparison of 12-week cumulative healing rates between the two groups. RESULTS: A statistically significant difference (P = 0.015) in the cumulative healing rate was observed between patients given ranitidine plus cisapride (82%) and those given ranitidine alone (71%). Oesophagitis in patients who received the combination was twice as likely to heal as that in patients who received ranitidine alone. CONCLUSION: A combination of 150 mg ranitidine twice daily and 20 mg cisapride twice daily is a safe and effective treatment for moderate-to-severe reflux oesophagitis and offers increased efficacy over ranitidine alone. SN - 0954-691X UR - https://www.unboundmedicine.com/medline/citation/8574711/Combination_of_ranitidine_and_cisapride_in_the_treatment_of_reflux_oesophagitis_ L2 - https://www.lens.org/lens/search?q=citation_id:8574711 DB - PRIME DP - Unbound Medicine ER -