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Relationship between Helicobacter pylori infection, atrophic gastritis and gastric carcinoma in a Japanese population.
Eur J Gastroenterol Hepatol 1995; 7 Suppl 1:S7-10EJ

Abstract

AIM

To evaluate the possible relationship between Helicobacter pylori infection and gastric carcinoma, and its precursor lesion, intestinal metaplasia, in a Japanese population.

SUBJECTS AND METHODS

H. pylori infection was identified by the presence of anti-H. pylori immunoglobulin (Ig)G. The frequency of H. pylori infection was compared in 109 patients with gastric carcinoma, the same number of patients with atrophic gastritis and asymptomatic controls matched for age, sex and place of birth. To study the relation between H. pylori and intestinal metaplasia, sera and gastric antral and corpus mucosal biopsies were obtained from 58 asymptomatic controls, 92 patients with chronic gastritis and 80 patients with peptic ulcer.

RESULTS

The presence of IgG antibody to H. pylori was significantly more frequent in those with gastric carcinoma than in asymptomatic controls (87.2 versus 74.3%; odds ratio 2.4; 95% confidence interval 1.2-4.8). The positive rates of H. pylori IgG antibody were 80.7% in patients with atrophic gastritis. Mean serum gastrin and pepsinogen II levels in H. pylori-positive patients were higher than those in H. pylori-negative patients. Serum gastrin and pepsinogen I levels were significantly higher in controls than gastric carcinoma patients (P < 0.01 and P < 0.05, respectively). Serum pepsinogen I:II ratios were significantly lower in controls than in gastric carcinoma patients (P < 0.01). Intestinal metaplasia was strongly associated with H. pylori infection, and was only found in patients with IgG antibodies to H. pylori.

CONCLUSIONS

These results suggest that H. pylori infection is associated with the development of gastric cancer by providing a suitable environment for carcinogenesis of the gastric mucosa, such as gastric atrophy and intestinal metaplasia.

Authors+Show Affiliations

Third Department of Internal Medicine, Hokkaido University School of Medicine, Sapporo, Japan.No affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Comparative Study
Journal Article

Language

eng

PubMed ID

8574741

Citation

Asaka, M, et al. "Relationship Between Helicobacter Pylori Infection, Atrophic Gastritis and Gastric Carcinoma in a Japanese Population." European Journal of Gastroenterology & Hepatology, vol. 7 Suppl 1, 1995, pp. S7-10.
Asaka M, Kato M, Kudo M, et al. Relationship between Helicobacter pylori infection, atrophic gastritis and gastric carcinoma in a Japanese population. Eur J Gastroenterol Hepatol. 1995;7 Suppl 1:S7-10.
Asaka, M., Kato, M., Kudo, M., Katagiri, M., Nishikawa, K., Yoshida, J., ... Miki, K. (1995). Relationship between Helicobacter pylori infection, atrophic gastritis and gastric carcinoma in a Japanese population. European Journal of Gastroenterology & Hepatology, 7 Suppl 1, pp. S7-10.
Asaka M, et al. Relationship Between Helicobacter Pylori Infection, Atrophic Gastritis and Gastric Carcinoma in a Japanese Population. Eur J Gastroenterol Hepatol. 1995;7 Suppl 1:S7-10. PubMed PMID: 8574741.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Relationship between Helicobacter pylori infection, atrophic gastritis and gastric carcinoma in a Japanese population. AU - Asaka,M, AU - Kato,M, AU - Kudo,M, AU - Katagiri,M, AU - Nishikawa,K, AU - Yoshida,J, AU - Takeda,H, AU - Miki,K, PY - 1995/8/1/pubmed PY - 1995/8/1/medline PY - 1995/8/1/entrez SP - S7 EP - 10 JF - European journal of gastroenterology & hepatology JO - Eur J Gastroenterol Hepatol VL - 7 Suppl 1 N2 - AIM: To evaluate the possible relationship between Helicobacter pylori infection and gastric carcinoma, and its precursor lesion, intestinal metaplasia, in a Japanese population. SUBJECTS AND METHODS: H. pylori infection was identified by the presence of anti-H. pylori immunoglobulin (Ig)G. The frequency of H. pylori infection was compared in 109 patients with gastric carcinoma, the same number of patients with atrophic gastritis and asymptomatic controls matched for age, sex and place of birth. To study the relation between H. pylori and intestinal metaplasia, sera and gastric antral and corpus mucosal biopsies were obtained from 58 asymptomatic controls, 92 patients with chronic gastritis and 80 patients with peptic ulcer. RESULTS: The presence of IgG antibody to H. pylori was significantly more frequent in those with gastric carcinoma than in asymptomatic controls (87.2 versus 74.3%; odds ratio 2.4; 95% confidence interval 1.2-4.8). The positive rates of H. pylori IgG antibody were 80.7% in patients with atrophic gastritis. Mean serum gastrin and pepsinogen II levels in H. pylori-positive patients were higher than those in H. pylori-negative patients. Serum gastrin and pepsinogen I levels were significantly higher in controls than gastric carcinoma patients (P < 0.01 and P < 0.05, respectively). Serum pepsinogen I:II ratios were significantly lower in controls than in gastric carcinoma patients (P < 0.01). Intestinal metaplasia was strongly associated with H. pylori infection, and was only found in patients with IgG antibodies to H. pylori. CONCLUSIONS: These results suggest that H. pylori infection is associated with the development of gastric cancer by providing a suitable environment for carcinogenesis of the gastric mucosa, such as gastric atrophy and intestinal metaplasia. SN - 0954-691X UR - https://www.unboundmedicine.com/medline/citation/8574741/Relationship_between_Helicobacter_pylori_infection_atrophic_gastritis_and_gastric_carcinoma_in_a_Japanese_population_ L2 - https://medlineplus.gov/helicobacterpyloriinfections.html DB - PRIME DP - Unbound Medicine ER -