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Open study of topical 0.025% tretinoin in the treatment of vulvar lichen sclerosus. One year of therapy.
J Reprod Med. 1995 Sep; 40(9):614-8.JR

Abstract

OBJECTIVE

To study the use of topical tretinoin for treating vulvar lichen sclerosus.

STUDY DESIGN

An open, uncontrolled clinical study on 22 patients affected by histologically confirmed vulvar lichen sclerosus. Topical 0.025% tretinoin was applied once a day, five days a week, for one year. Clinical and histologic parameters were evaluated before and after therapy, and statistical analysis was performed.

RESULTS

Symptoms, gross appearance and histopathologic features improved in a highly significant manner (P < .001). Cutaneous side effects were observed but rapidly disappeared, and no patient left the study for this reason. Maintenance of results was observed at the 4-13-month follow-up visits.

CONCLUSION

Topical tretinoin seems feasible for use in the topical treatment of vulvar lichen sclerosus.

Authors+Show Affiliations

Virgili A
Clinica Dermatologica, Università di Ferrara, Italy.
Corazza M
No affiliation info available
Bianchi A
No affiliation info available
Mollica G
No affiliation info available
Califano A
No affiliation info available

MeSH

Administration, TopicalAdultAgedBiopsyDose-Response Relationship, DrugFemaleHumansKeratolytic AgentsLichen Sclerosus et AtrophicusMiddle AgedSkin DiseasesTime FactorsTretinoinVulvaVulvar Diseases

Pub Type(s)

Clinical Trial
Journal Article

Language

eng

PubMed ID

8576875

Citation

Virgili, A, et al. "Open Study of Topical 0.025% Tretinoin in the Treatment of Vulvar Lichen Sclerosus. One Year of Therapy." The Journal of Reproductive Medicine, vol. 40, no. 9, 1995, pp. 614-8.
Virgili A, Corazza M, Bianchi A, et al. Open study of topical 0.025% tretinoin in the treatment of vulvar lichen sclerosus. One year of therapy. J Reprod Med. 1995;40(9):614-8.
Virgili, A., Corazza, M., Bianchi, A., Mollica, G., & Califano, A. (1995). Open study of topical 0.025% tretinoin in the treatment of vulvar lichen sclerosus. One year of therapy. The Journal of Reproductive Medicine, 40(9), 614-8.
Virgili A, et al. Open Study of Topical 0.025% Tretinoin in the Treatment of Vulvar Lichen Sclerosus. One Year of Therapy. J Reprod Med. 1995;40(9):614-8. PubMed PMID: 8576875.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Open study of topical 0.025% tretinoin in the treatment of vulvar lichen sclerosus. One year of therapy. AU - Virgili,A, AU - Corazza,M, AU - Bianchi,A, AU - Mollica,G, AU - Califano,A, PY - 1995/9/1/pubmed PY - 1995/9/1/medline PY - 1995/9/1/entrez SP - 614 EP - 8 JF - The Journal of reproductive medicine JO - J Reprod Med VL - 40 IS - 9 N2 - OBJECTIVE: To study the use of topical tretinoin for treating vulvar lichen sclerosus. STUDY DESIGN: An open, uncontrolled clinical study on 22 patients affected by histologically confirmed vulvar lichen sclerosus. Topical 0.025% tretinoin was applied once a day, five days a week, for one year. Clinical and histologic parameters were evaluated before and after therapy, and statistical analysis was performed. RESULTS: Symptoms, gross appearance and histopathologic features improved in a highly significant manner (P < .001). Cutaneous side effects were observed but rapidly disappeared, and no patient left the study for this reason. Maintenance of results was observed at the 4-13-month follow-up visits. CONCLUSION: Topical tretinoin seems feasible for use in the topical treatment of vulvar lichen sclerosus. SN - 0024-7758 UR - https://www.unboundmedicine.com/medline/citation/8576875/Open_study_of_topical_0_025_tretinoin_in_the_treatment_of_vulvar_lichen_sclerosus__One_year_of_therapy_ DB - PRIME DP - Unbound Medicine ER -