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Effect of dietary antioxidant trace element supply on cardiac tolerance to ischemia-reperfusion in the rat.
J Mol Cell Cardiol 1995; 27(10):2303-14JM

Abstract

Over a 10-week period, female Wistar rats received a diet containing various levels of four trace elements (Zn, Cu, Mn, Se), co-factors of antioxidant enzymes (superoxide dismutase SOD, glutathione peroxidase GPx), in order to examine the influence of supplementation or deficiency of these elements (i) on tissue antioxidant enzyme defence systems, and (ii) on the susceptibility of the myocardium to ischemia-reperfusion injury. At the end of the dietary treatment, hearts were perfused at constant flow (11 ml/min) before being subjected to 15 min of total global normothermic ischemia, followed by reperfusion. The effects of the various diets (deficient, standard or supplemented) were estimated by studying functional recovery of various cardiac parameters (left ventricular developed pressure LVDP, dP/dtmax, heart rate x LVDP) as well as ultrastructural tissue characteristics. Furthermore, SOD and GPx activities were measured before ischemia and at the end of the reperfusion period. Results suggest that: (a) the activity of antioxidant enzymes increased or decreased significantly when diet was respectively supplemented with, or deficient in, trace elements, but was not further modified by an ischemia-reperfusion episode: (b) the recovery of cardiac function during reperfusion, and ventricular myocardial ultrastructure were significantly improved under the influence of trace element supplementation when compared to both standard and deficient groups. These results illustrate the protective effect of trace elements which are co-factors of antioxidant enzymes in limiting ischemia-reperfusion induced injury, and suggest a possible use in the field of anti-ischemic therapy.

Authors+Show Affiliations

Groupe de Physiopathologie Cellulaire Cardiaque, URA CNRS 1287, Université Joseph Fourier, Grenoble, France.

Pub Type(s)

Journal Article
Research Support, Non-U.S. Gov't

Language

eng

PubMed ID

8576945

Citation

Pucheu, S, et al. "Effect of Dietary Antioxidant Trace Element Supply On Cardiac Tolerance to Ischemia-reperfusion in the Rat." Journal of Molecular and Cellular Cardiology, vol. 27, no. 10, 1995, pp. 2303-14.
Pucheu S, Coudray C, Tresallet N, et al. Effect of dietary antioxidant trace element supply on cardiac tolerance to ischemia-reperfusion in the rat. J Mol Cell Cardiol. 1995;27(10):2303-14.
Pucheu, S., Coudray, C., Tresallet, N., Favier, A., & de Leiris, J. (1995). Effect of dietary antioxidant trace element supply on cardiac tolerance to ischemia-reperfusion in the rat. Journal of Molecular and Cellular Cardiology, 27(10), pp. 2303-14.
Pucheu S, et al. Effect of Dietary Antioxidant Trace Element Supply On Cardiac Tolerance to Ischemia-reperfusion in the Rat. J Mol Cell Cardiol. 1995;27(10):2303-14. PubMed PMID: 8576945.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Effect of dietary antioxidant trace element supply on cardiac tolerance to ischemia-reperfusion in the rat. AU - Pucheu,S, AU - Coudray,C, AU - Tresallet,N, AU - Favier,A, AU - de Leiris,J, PY - 1995/10/1/pubmed PY - 1995/10/1/medline PY - 1995/10/1/entrez SP - 2303 EP - 14 JF - Journal of molecular and cellular cardiology JO - J. Mol. Cell. Cardiol. VL - 27 IS - 10 N2 - Over a 10-week period, female Wistar rats received a diet containing various levels of four trace elements (Zn, Cu, Mn, Se), co-factors of antioxidant enzymes (superoxide dismutase SOD, glutathione peroxidase GPx), in order to examine the influence of supplementation or deficiency of these elements (i) on tissue antioxidant enzyme defence systems, and (ii) on the susceptibility of the myocardium to ischemia-reperfusion injury. At the end of the dietary treatment, hearts were perfused at constant flow (11 ml/min) before being subjected to 15 min of total global normothermic ischemia, followed by reperfusion. The effects of the various diets (deficient, standard or supplemented) were estimated by studying functional recovery of various cardiac parameters (left ventricular developed pressure LVDP, dP/dtmax, heart rate x LVDP) as well as ultrastructural tissue characteristics. Furthermore, SOD and GPx activities were measured before ischemia and at the end of the reperfusion period. Results suggest that: (a) the activity of antioxidant enzymes increased or decreased significantly when diet was respectively supplemented with, or deficient in, trace elements, but was not further modified by an ischemia-reperfusion episode: (b) the recovery of cardiac function during reperfusion, and ventricular myocardial ultrastructure were significantly improved under the influence of trace element supplementation when compared to both standard and deficient groups. These results illustrate the protective effect of trace elements which are co-factors of antioxidant enzymes in limiting ischemia-reperfusion induced injury, and suggest a possible use in the field of anti-ischemic therapy. SN - 0022-2828 UR - https://www.unboundmedicine.com/medline/citation/8576945/Effect_of_dietary_antioxidant_trace_element_supply_on_cardiac_tolerance_to_ischemia_reperfusion_in_the_rat_ L2 - https://medlineplus.gov/antioxidants.html DB - PRIME DP - Unbound Medicine ER -