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Impact of enteral feeding of a glutamine-supplemented formula on the hypoaminoacidemic response in trauma patients.
J Trauma 1996; 40(1):97-102JT

Abstract

Plasma amino acid concentrations were measured during fasting and after 3 days of enteral feeding in 16 trauma patients on a glutamine-supplemented diet and 14 patients on an isonitrogenous control diet. During fasting, total amino acids, including glutamine, were depressed by 50% and this was attributed to a reduction in both essential and nonessential amino acids. The essential amino acid concentrations increased in both groups after feeding. The nonessential amino acid concentrations also increased in the control group but not in the glutamine group during feeding. Repletion of the glutamine extracellular pool was not evident after an average intake of 27.1 g per day of glutamine for 3 days. Nitrogen balance was similar for the two groups during feeding. We conclude that in this study, enteral glutamine did not increase the glutamine plasma concentration. In addition, both formulas improved the hypoaminoacidemia of essential amino acids but only the control diet improved the nonessential amino acids plasma concentration.

Authors+Show Affiliations

Department of Research, Carraway Methodist Medical Center, Birmingham, AL 35234, USA.No affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Clinical Trial
Comparative Study
Journal Article
Randomized Controlled Trial
Research Support, Non-U.S. Gov't

Language

eng

PubMed ID

8577007

Citation

Long, C L., et al. "Impact of Enteral Feeding of a Glutamine-supplemented Formula On the Hypoaminoacidemic Response in Trauma Patients." The Journal of Trauma, vol. 40, no. 1, 1996, pp. 97-102.
Long CL, Borghesi L, Stahl R, et al. Impact of enteral feeding of a glutamine-supplemented formula on the hypoaminoacidemic response in trauma patients. J Trauma. 1996;40(1):97-102.
Long, C. L., Borghesi, L., Stahl, R., Clark, J. A., Geiger, J. W., DiRienzo, D. B., ... Blakemore, W. S. (1996). Impact of enteral feeding of a glutamine-supplemented formula on the hypoaminoacidemic response in trauma patients. The Journal of Trauma, 40(1), pp. 97-102.
Long CL, et al. Impact of Enteral Feeding of a Glutamine-supplemented Formula On the Hypoaminoacidemic Response in Trauma Patients. J Trauma. 1996;40(1):97-102. PubMed PMID: 8577007.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Impact of enteral feeding of a glutamine-supplemented formula on the hypoaminoacidemic response in trauma patients. AU - Long,C L, AU - Borghesi,L, AU - Stahl,R, AU - Clark,J A, AU - Geiger,J W, AU - DiRienzo,D B, AU - Weis,J K, AU - Laws,H L, AU - Blakemore,W S, PY - 1996/1/1/pubmed PY - 1996/1/1/medline PY - 1996/1/1/entrez SP - 97 EP - 102 JF - The Journal of trauma JO - J Trauma VL - 40 IS - 1 N2 - Plasma amino acid concentrations were measured during fasting and after 3 days of enteral feeding in 16 trauma patients on a glutamine-supplemented diet and 14 patients on an isonitrogenous control diet. During fasting, total amino acids, including glutamine, were depressed by 50% and this was attributed to a reduction in both essential and nonessential amino acids. The essential amino acid concentrations increased in both groups after feeding. The nonessential amino acid concentrations also increased in the control group but not in the glutamine group during feeding. Repletion of the glutamine extracellular pool was not evident after an average intake of 27.1 g per day of glutamine for 3 days. Nitrogen balance was similar for the two groups during feeding. We conclude that in this study, enteral glutamine did not increase the glutamine plasma concentration. In addition, both formulas improved the hypoaminoacidemia of essential amino acids but only the control diet improved the nonessential amino acids plasma concentration. SN - 0022-5282 UR - https://www.unboundmedicine.com/medline/citation/8577007/Impact_of_enteral_feeding_of_a_glutamine_supplemented_formula_on_the_hypoaminoacidemic_response_in_trauma_patients_ L2 - http://Insights.ovid.com/pubmed?pmid=8577007 DB - PRIME DP - Unbound Medicine ER -