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Omeprazole in the long-term treatment of gastro-oesophageal reflux disease. A double-blind randomized dose-finding study.
Scand J Gastroenterol. 1995 Sep; 30(9):839-46.SJ

Abstract

BACKGROUND

Omeprazole is effective in the treatment of reflux oesophagitis, and it is important to determine the lower dose limit with still appropriate clinical efficacy.

METHODS

Patients with endoscopic oesophagitis grade 1-4 (N = 220) were randomized to double-blind treatment with 20 mg or 40 mg omeprazole daily for 4-8 weeks. Those healed after this initial treatment phase were re-randomized to double-blind treatment with 20 mg omeprazole daily (n = 67), 10 mg omeprazole daily (n = 68), or placebo (n = 33) for 6 months. Remission was defined as the absence of any endoscopic sign of oesophagitis.

RESULTS

Healing rates were increased with 40 mg omeprazole, the therapeutic gain compared with the 20-mg dose being 15% after 4 and 8 weeks. The proportion of patients in remission after 6 months was 59% with 20 mg omeprazole, 35% with 10 mg omeprazole, and 0% with placebo.

CONCLUSION

Maintenance treatment with 10 mg omeprazole can prevent recurrence of oesophagitis in about one-third of patients with all grades of oesophagitis, and 20 mg omeprazole in about twice as many.

Authors+Show Affiliations

Dept. of Medical Gastroenterology, Odense University Hospital, Denmark.No affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Clinical Trial
Journal Article
Randomized Controlled Trial

Language

eng

PubMed ID

8578181

Citation

Laursen, L S., et al. "Omeprazole in the Long-term Treatment of Gastro-oesophageal Reflux Disease. a Double-blind Randomized Dose-finding Study." Scandinavian Journal of Gastroenterology, vol. 30, no. 9, 1995, pp. 839-46.
Laursen LS, Havelund T, Bondesen S, et al. Omeprazole in the long-term treatment of gastro-oesophageal reflux disease. A double-blind randomized dose-finding study. Scand J Gastroenterol. 1995;30(9):839-46.
Laursen, L. S., Havelund, T., Bondesen, S., Hansen, J., Sanchez, G., Sebelin, E., Fenger, C., & Lauritsen, K. (1995). Omeprazole in the long-term treatment of gastro-oesophageal reflux disease. A double-blind randomized dose-finding study. Scandinavian Journal of Gastroenterology, 30(9), 839-46.
Laursen LS, et al. Omeprazole in the Long-term Treatment of Gastro-oesophageal Reflux Disease. a Double-blind Randomized Dose-finding Study. Scand J Gastroenterol. 1995;30(9):839-46. PubMed PMID: 8578181.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Omeprazole in the long-term treatment of gastro-oesophageal reflux disease. A double-blind randomized dose-finding study. AU - Laursen,L S, AU - Havelund,T, AU - Bondesen,S, AU - Hansen,J, AU - Sanchez,G, AU - Sebelin,E, AU - Fenger,C, AU - Lauritsen,K, PY - 1995/9/1/pubmed PY - 1995/9/1/medline PY - 1995/9/1/entrez SP - 839 EP - 46 JF - Scandinavian journal of gastroenterology JO - Scand J Gastroenterol VL - 30 IS - 9 N2 - BACKGROUND: Omeprazole is effective in the treatment of reflux oesophagitis, and it is important to determine the lower dose limit with still appropriate clinical efficacy. METHODS: Patients with endoscopic oesophagitis grade 1-4 (N = 220) were randomized to double-blind treatment with 20 mg or 40 mg omeprazole daily for 4-8 weeks. Those healed after this initial treatment phase were re-randomized to double-blind treatment with 20 mg omeprazole daily (n = 67), 10 mg omeprazole daily (n = 68), or placebo (n = 33) for 6 months. Remission was defined as the absence of any endoscopic sign of oesophagitis. RESULTS: Healing rates were increased with 40 mg omeprazole, the therapeutic gain compared with the 20-mg dose being 15% after 4 and 8 weeks. The proportion of patients in remission after 6 months was 59% with 20 mg omeprazole, 35% with 10 mg omeprazole, and 0% with placebo. CONCLUSION: Maintenance treatment with 10 mg omeprazole can prevent recurrence of oesophagitis in about one-third of patients with all grades of oesophagitis, and 20 mg omeprazole in about twice as many. SN - 0036-5521 UR - https://www.unboundmedicine.com/medline/citation/8578181/Omeprazole_in_the_long_term_treatment_of_gastro_oesophageal_reflux_disease__A_double_blind_randomized_dose_finding_study_ L2 - https://www.tandfonline.com/doi/full/10.3109/00365529509101589 DB - PRIME DP - Unbound Medicine ER -