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Droloxifene inhibits cortical bone turnover associated with estrogen deficiency in rats.
Bone. 1995 Oct; 17(4 Suppl):175S-179S.BONE

Abstract

Droloxifene (DRO), an estrogen antagonist/agonist, has been shown to possess estrogen-like effects in inhibiting bone turnover leading to cancellous bone loss in ovariectomized (OVX) rats. The purpose of this study was to determine the effects of DRO on cortical bone turnover in OVX rats. Sprague-Dawley female rats at 5 months of age were sham-operated (sham, n = 8) and orally treated with vehicle, or OVX (n = 56) and orally treated with either vehicle, DRO at 0.1, 1, 5, or 10 mg/kg/day, or 17 alpha-ethynyl estradiol (EE) at 3 or 30 micrograms/kg/day for 4 weeks. Static and dynamic cortical bone histomorphometry was performed on double fluorescent labeled, undecalcified cross sections of tibial diaphyses (proximal to the tibiofibular junction). There were no significant differences in tibial diaphyseal cross sectional area, marrow cavity area, and cortical bone area between groups after 4 weeks of administration. Periosteal mineralizing surface, mineral apposition rate, and bone formation rate-surface referent and endocortical eroded surface increased significantly, while endocortical mineral apposition rate and bone formation rate-surface referent increased nonsignificantly in OVX controls compared to sham controls. Treatment with DRO at doses of 0.1 to 10 mg/kg/day dose-dependently attenuated the OVX-induced higher bone formation indices in both the periosteal and endocortical surfaces and higher bone resorption index in the endocortical surface. At the highest dose (10 mg/kg/day), DRO completely inhibited the increases in bone formation and resorption indices in OVX rats.(

ABSTRACT

TRUNCATED AT 250 WORDS)

Authors+Show Affiliations

Division of Radiobiology, University of Utah School of Medicine, Salt Lake City 84112, USA.No affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Journal Article

Language

eng

PubMed ID

8579914

Citation

Chen, H K., et al. "Droloxifene Inhibits Cortical Bone Turnover Associated With Estrogen Deficiency in Rats." Bone, vol. 17, no. 4 Suppl, 1995, 175S-179S.
Chen HK, Ke HZ, Lin CH, et al. Droloxifene inhibits cortical bone turnover associated with estrogen deficiency in rats. Bone. 1995;17(4 Suppl):175S-179S.
Chen, H. K., Ke, H. Z., Lin, C. H., Ma, Y. F., Qi, H., Crawford, D. T., Pirie, C. M., Simmons, H. A., Jee, W. S., & Thompson, D. D. (1995). Droloxifene inhibits cortical bone turnover associated with estrogen deficiency in rats. Bone, 17(4 Suppl), 175S-179S.
Chen HK, et al. Droloxifene Inhibits Cortical Bone Turnover Associated With Estrogen Deficiency in Rats. Bone. 1995;17(4 Suppl):175S-179S. PubMed PMID: 8579914.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Droloxifene inhibits cortical bone turnover associated with estrogen deficiency in rats. AU - Chen,H K, AU - Ke,H Z, AU - Lin,C H, AU - Ma,Y F, AU - Qi,H, AU - Crawford,D T, AU - Pirie,C M, AU - Simmons,H A, AU - Jee,W S, AU - Thompson,D D, PY - 1995/10/1/pubmed PY - 1995/10/1/medline PY - 1995/10/1/entrez SP - 175S EP - 179S JF - Bone JO - Bone VL - 17 IS - 4 Suppl N2 - Droloxifene (DRO), an estrogen antagonist/agonist, has been shown to possess estrogen-like effects in inhibiting bone turnover leading to cancellous bone loss in ovariectomized (OVX) rats. The purpose of this study was to determine the effects of DRO on cortical bone turnover in OVX rats. Sprague-Dawley female rats at 5 months of age were sham-operated (sham, n = 8) and orally treated with vehicle, or OVX (n = 56) and orally treated with either vehicle, DRO at 0.1, 1, 5, or 10 mg/kg/day, or 17 alpha-ethynyl estradiol (EE) at 3 or 30 micrograms/kg/day for 4 weeks. Static and dynamic cortical bone histomorphometry was performed on double fluorescent labeled, undecalcified cross sections of tibial diaphyses (proximal to the tibiofibular junction). There were no significant differences in tibial diaphyseal cross sectional area, marrow cavity area, and cortical bone area between groups after 4 weeks of administration. Periosteal mineralizing surface, mineral apposition rate, and bone formation rate-surface referent and endocortical eroded surface increased significantly, while endocortical mineral apposition rate and bone formation rate-surface referent increased nonsignificantly in OVX controls compared to sham controls. Treatment with DRO at doses of 0.1 to 10 mg/kg/day dose-dependently attenuated the OVX-induced higher bone formation indices in both the periosteal and endocortical surfaces and higher bone resorption index in the endocortical surface. At the highest dose (10 mg/kg/day), DRO completely inhibited the increases in bone formation and resorption indices in OVX rats.(ABSTRACT TRUNCATED AT 250 WORDS) SN - 8756-3282 UR - https://www.unboundmedicine.com/medline/citation/8579914/Droloxifene_inhibits_cortical_bone_turnover_associated_with_estrogen_deficiency_in_rats_ L2 - https://linkinghub.elsevier.com/retrieve/pii/8756-3282(95)00290-T DB - PRIME DP - Unbound Medicine ER -