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Tyramine conjugation deficit in migraine, tension-type headache, and depression.
Biol Psychiatry. 1995 Dec 01; 38(11):730-6.BP

Abstract

This study was designed to investigate tyramine sulfate conjugation in patients with migraine or tension-type headache, as defined by the newly introduced International Headache Society (IHS) criteria and to examine whether this relationship is mediated by major depression. A total of 62 subjects completed the study: 38 with migraine (22 with aura and 16 without aura), 12 with tension-type headache, and 12 controls. Patients with migraine had significantly lower urinary tyramine sulfate excretion following oral tyramine challenge than normal control. Tension-type headache was also associated with low tyramine conjugation, but only when comorbid with depression. Although mean tyramine sulfate output was lower among subjects with major depression within each of the subtypes of headache, no significant main effect emerged for depression or major subtype thereof. The lower tyramine sulfate excretion values among patients with both migraine and depression compared to those of migraine alone or depression alone in our data and those of others suggests that comorbid migraine with depression may represent a more severe form of migraine than migraine alone. The findings underscore the importance of comorbidity in clinical and epidemiological studies of migraine.

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Authors+Show Affiliations

Merikangas KR
Department of Psychiatry and Epidemiology, Yale University School of Medicine, New Haven, Connecticut 06510, USA.
Stevens DE
No affiliation info available
Merikangas JR
No affiliation info available
Katz CB
No affiliation info available
Glover V
No affiliation info available
Cooper T
No affiliation info available
Sandler M
No affiliation info available

MeSH

AdultDepressive DisorderFemaleHumansMaleMigraine DisordersPsychiatric Status Rating ScalesRecurrenceTension-Type HeadacheTyramine

Pub Type(s)

Clinical Trial
Journal Article
Research Support, Non-U.S. Gov't
Research Support, U.S. Gov't, P.H.S.

Language

eng

PubMed ID

8580225

Citation

Merikangas, K R., et al. "Tyramine Conjugation Deficit in Migraine, Tension-type Headache, and Depression." Biological Psychiatry, vol. 38, no. 11, 1995, pp. 730-6.
Merikangas KR, Stevens DE, Merikangas JR, et al. Tyramine conjugation deficit in migraine, tension-type headache, and depression. Biol Psychiatry. 1995;38(11):730-6.
Merikangas, K. R., Stevens, D. E., Merikangas, J. R., Katz, C. B., Glover, V., Cooper, T., & Sandler, M. (1995). Tyramine conjugation deficit in migraine, tension-type headache, and depression. Biological Psychiatry, 38(11), 730-6.
Merikangas KR, et al. Tyramine Conjugation Deficit in Migraine, Tension-type Headache, and Depression. Biol Psychiatry. 1995 Dec 1;38(11):730-6. PubMed PMID: 8580225.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Tyramine conjugation deficit in migraine, tension-type headache, and depression. AU - Merikangas,K R, AU - Stevens,D E, AU - Merikangas,J R, AU - Katz,C B, AU - Glover,V, AU - Cooper,T, AU - Sandler,M, PY - 1995/12/1/pubmed PY - 1995/12/1/medline PY - 1995/12/1/entrez SP - 730 EP - 6 JF - Biological psychiatry JO - Biol Psychiatry VL - 38 IS - 11 N2 - This study was designed to investigate tyramine sulfate conjugation in patients with migraine or tension-type headache, as defined by the newly introduced International Headache Society (IHS) criteria and to examine whether this relationship is mediated by major depression. A total of 62 subjects completed the study: 38 with migraine (22 with aura and 16 without aura), 12 with tension-type headache, and 12 controls. Patients with migraine had significantly lower urinary tyramine sulfate excretion following oral tyramine challenge than normal control. Tension-type headache was also associated with low tyramine conjugation, but only when comorbid with depression. Although mean tyramine sulfate output was lower among subjects with major depression within each of the subtypes of headache, no significant main effect emerged for depression or major subtype thereof. The lower tyramine sulfate excretion values among patients with both migraine and depression compared to those of migraine alone or depression alone in our data and those of others suggests that comorbid migraine with depression may represent a more severe form of migraine than migraine alone. The findings underscore the importance of comorbidity in clinical and epidemiological studies of migraine. SN - 0006-3223 UR - https://www.unboundmedicine.com/medline/citation/8580225/Tyramine_conjugation_deficit_in_migraine_tension_type_headache_and_depression_ L2 - https://linkinghub.elsevier.com/retrieve/pii/0006-3223(95)00045-3 DB - PRIME DP - Unbound Medicine ER -