Tags

Type your tag names separated by a space and hit enter

Fatty acid composition of breast adipose tissue in breast cancer patients and in patients with benign breast disease.
Nutr Cancer. 1995; 24(2):151-60.NC

Abstract

Fatty acid composition of triglycerides (TGs) and phospholipids (PLs) in breast adipose tissue was analyzed in 73 female breast cancer patients and 55 patients with benign breast disease. No differences were observed in the dietary intake of the major fatty acids (i.e., palmitic, stearic, oleic, and linoleic acids) or in the proportion of TGs and PLs in breast adipose tissue between the two groups. In postmenopausal women, however, the dietary intake of eicosapentaenoic acid (20:5n-3) and docosahexaenoic acid (22:6n-3) was significantly lower in the breast cancer patients than in patients with benign breast disease. Accordingly, the percentage of docosahexaenoic acid of PLs in breast adipose tissue was significantly lower in breast cancer patients than in patients with benign breast disease among postmenopausal women. The stage of the breast cancer did not contribute to the observed alterations of fatty acid composition of PLs. Consonant with the previous epidemiologic data, the present results suggest that intake of the long-chain n-3 fatty acids (mainly derived from fish) may have a protective effect against breast cancer, particularly in postmenopausal women.

Authors+Show Affiliations

Department of Clinical Nutrition, University of Kuopio, Finland.No affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Journal Article
Research Support, Non-U.S. Gov't

Language

eng

PubMed ID

8584451

Citation

Zhu, Z R., et al. "Fatty Acid Composition of Breast Adipose Tissue in Breast Cancer Patients and in Patients With Benign Breast Disease." Nutrition and Cancer, vol. 24, no. 2, 1995, pp. 151-60.
Zhu ZR, Agren J, Männistö S, et al. Fatty acid composition of breast adipose tissue in breast cancer patients and in patients with benign breast disease. Nutr Cancer. 1995;24(2):151-60.
Zhu, Z. R., Agren, J., Männistö, S., Pietinen, P., Eskelinen, M., Syrjänen, K., & Uusitupa, M. (1995). Fatty acid composition of breast adipose tissue in breast cancer patients and in patients with benign breast disease. Nutrition and Cancer, 24(2), 151-60.
Zhu ZR, et al. Fatty Acid Composition of Breast Adipose Tissue in Breast Cancer Patients and in Patients With Benign Breast Disease. Nutr Cancer. 1995;24(2):151-60. PubMed PMID: 8584451.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Fatty acid composition of breast adipose tissue in breast cancer patients and in patients with benign breast disease. AU - Zhu,Z R, AU - Agren,J, AU - Männistö,S, AU - Pietinen,P, AU - Eskelinen,M, AU - Syrjänen,K, AU - Uusitupa,M, PY - 1995/1/1/pubmed PY - 1995/1/1/medline PY - 1995/1/1/entrez SP - 151 EP - 60 JF - Nutrition and cancer JO - Nutr Cancer VL - 24 IS - 2 N2 - Fatty acid composition of triglycerides (TGs) and phospholipids (PLs) in breast adipose tissue was analyzed in 73 female breast cancer patients and 55 patients with benign breast disease. No differences were observed in the dietary intake of the major fatty acids (i.e., palmitic, stearic, oleic, and linoleic acids) or in the proportion of TGs and PLs in breast adipose tissue between the two groups. In postmenopausal women, however, the dietary intake of eicosapentaenoic acid (20:5n-3) and docosahexaenoic acid (22:6n-3) was significantly lower in the breast cancer patients than in patients with benign breast disease. Accordingly, the percentage of docosahexaenoic acid of PLs in breast adipose tissue was significantly lower in breast cancer patients than in patients with benign breast disease among postmenopausal women. The stage of the breast cancer did not contribute to the observed alterations of fatty acid composition of PLs. Consonant with the previous epidemiologic data, the present results suggest that intake of the long-chain n-3 fatty acids (mainly derived from fish) may have a protective effect against breast cancer, particularly in postmenopausal women. SN - 0163-5581 UR - https://www.unboundmedicine.com/medline/citation/8584451/Fatty_acid_composition_of_breast_adipose_tissue_in_breast_cancer_patients_and_in_patients_with_benign_breast_disease_ L2 - https://www.tandfonline.com/doi/full/10.1080/01635589509514403 DB - PRIME DP - Unbound Medicine ER -