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Vitamin D status and sex hormone binding globulin: determinants of bone turnover and bone mineral density in elderly women.
J Bone Miner Res 1995; 10(8):1177-84JB

Abstract

To examine the relation of the vitamin D status and the remaining estrogen activity with bone turnover and bone mineral density (BMD) in elderly women, BMD was measured at both hips using dual-energy X-ray absorptiometry and at the distal radius using single photon absorptiometry, in 330 healthy women aged 70 and over. Vitamin D metabolites, sex hormone binding globulin (SHBG), PTH(1-84), osteocalcin, alkaline phosphatase, and hydroxyproline and calcium excretion in 2 h fasting urine were measured. Multiple linear regression was used to adjust for potential confounders. In 65% of the women, serum 25(OH)D was below 30 nmol/l. Only values below a threshold for 25(OH)D were negatively related to serum PTH(1-84) (p = 0.02, threshold at 25 nmol/l) and to osteocalcin levels (p = 0.04, threshold at 30 nmol/l). BMD of the femoral neck and trochanter was positively related to serum 25(OH)D (left neck p = 0.001) with thresholds at 30 nmol/l whereas the distal radius was not (p = 0.32). Serum PTH was negatively related to BMD at all measurement sites (all p < 0.001). Serum SHBG, an inverse measure of estrogen activity, was positively related to osteocalcin levels (p = 0.004) and the urinary hydroxyproline/creatinine ratio (p = 0.002) and negatively related to the BMD of the trochanter (left trochanter p = 0.02) and the distal radius (p = 0.001). We conclude that in elderly women, serum 25(OH)D levels below 30 nmol/l are associated with secondary hyperparathyroidism and increased bone turnover. SHBG is positively related to bone turnover.(

ABSTRACT

TRUNCATED AT 250 WORDS)

Authors+Show Affiliations

Institute for Research in Extramural Medicine (EMGO-Institute) Vrije Universiteit, Amsterdam, The Netherlands.No affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Clinical Trial
Journal Article
Research Support, Non-U.S. Gov't

Language

eng

PubMed ID

8585420

Citation

Ooms, M E., et al. "Vitamin D Status and Sex Hormone Binding Globulin: Determinants of Bone Turnover and Bone Mineral Density in Elderly Women." Journal of Bone and Mineral Research : the Official Journal of the American Society for Bone and Mineral Research, vol. 10, no. 8, 1995, pp. 1177-84.
Ooms ME, Lips P, Roos JC, et al. Vitamin D status and sex hormone binding globulin: determinants of bone turnover and bone mineral density in elderly women. J Bone Miner Res. 1995;10(8):1177-84.
Ooms, M. E., Lips, P., Roos, J. C., van der Vijgh, W. J., Popp-Snijders, C., Bezemer, P. D., & Bouter, L. M. (1995). Vitamin D status and sex hormone binding globulin: determinants of bone turnover and bone mineral density in elderly women. Journal of Bone and Mineral Research : the Official Journal of the American Society for Bone and Mineral Research, 10(8), pp. 1177-84.
Ooms ME, et al. Vitamin D Status and Sex Hormone Binding Globulin: Determinants of Bone Turnover and Bone Mineral Density in Elderly Women. J Bone Miner Res. 1995;10(8):1177-84. PubMed PMID: 8585420.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Vitamin D status and sex hormone binding globulin: determinants of bone turnover and bone mineral density in elderly women. AU - Ooms,M E, AU - Lips,P, AU - Roos,J C, AU - van der Vijgh,W J, AU - Popp-Snijders,C, AU - Bezemer,P D, AU - Bouter,L M, PY - 1995/8/1/pubmed PY - 1995/8/1/medline PY - 1995/8/1/entrez SP - 1177 EP - 84 JF - Journal of bone and mineral research : the official journal of the American Society for Bone and Mineral Research JO - J. Bone Miner. Res. VL - 10 IS - 8 N2 - To examine the relation of the vitamin D status and the remaining estrogen activity with bone turnover and bone mineral density (BMD) in elderly women, BMD was measured at both hips using dual-energy X-ray absorptiometry and at the distal radius using single photon absorptiometry, in 330 healthy women aged 70 and over. Vitamin D metabolites, sex hormone binding globulin (SHBG), PTH(1-84), osteocalcin, alkaline phosphatase, and hydroxyproline and calcium excretion in 2 h fasting urine were measured. Multiple linear regression was used to adjust for potential confounders. In 65% of the women, serum 25(OH)D was below 30 nmol/l. Only values below a threshold for 25(OH)D were negatively related to serum PTH(1-84) (p = 0.02, threshold at 25 nmol/l) and to osteocalcin levels (p = 0.04, threshold at 30 nmol/l). BMD of the femoral neck and trochanter was positively related to serum 25(OH)D (left neck p = 0.001) with thresholds at 30 nmol/l whereas the distal radius was not (p = 0.32). Serum PTH was negatively related to BMD at all measurement sites (all p < 0.001). Serum SHBG, an inverse measure of estrogen activity, was positively related to osteocalcin levels (p = 0.004) and the urinary hydroxyproline/creatinine ratio (p = 0.002) and negatively related to the BMD of the trochanter (left trochanter p = 0.02) and the distal radius (p = 0.001). We conclude that in elderly women, serum 25(OH)D levels below 30 nmol/l are associated with secondary hyperparathyroidism and increased bone turnover. SHBG is positively related to bone turnover.(ABSTRACT TRUNCATED AT 250 WORDS) SN - 0884-0431 UR - https://www.unboundmedicine.com/medline/citation/8585420/Vitamin_D_status_and_sex_hormone_binding_globulin:_determinants_of_bone_turnover_and_bone_mineral_density_in_elderly_women_ DB - PRIME DP - Unbound Medicine ER -