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Exposure-response analysis of mortality among coal miners in the United States.
Am J Ind Med 1995; 28(2):167-84AJ

Abstract

The quantitative relationship between exposure to respirable coal mine dust and mortality from nonmalignant respiratory diseases was investigated in a study of 8,878 working male coal miners who were medically examined from 1969 to 1971 and followed to 1979. Exposure-related mortality was evaluated using Cox proportional hazards modeling for underlying or contributing causes of death and modified lifetable methods for underlying causes. For pneumoconiosis mortality, the lifetable analyses showed increasing standardized mortality ratios (SMRs) with increasing cumulative exposure category. Significant exposure-response relationships for mortality from pneumoconiosis (p < 0.001) and from chronic bronchitis or emphysema (p < 0.05) were observed in the proportional hazards models after controlling for age and smoking. No exposure-related increases in lung cancer or stomach cancer were observed. Pneumoconiosis mortality was found to vary significantly by the rank of coal dust to which miners were exposed. Miners exposed at or below the current U.S. coal dust standard of 2 mg/m3 over a working lifetime, based on these analyses, have an elevated risk of dying from pneumoconiosis or from chronic bronchitis or emphysema.

Authors+Show Affiliations

National Institute for Occupational Safety and Health (NIOSH), Division of Standards Development and Technology Transfer, Cincinnati, OH, 45226, USA.No affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Journal Article

Language

eng

PubMed ID

8585515

Citation

Kuempel, E D., et al. "Exposure-response Analysis of Mortality Among Coal Miners in the United States." American Journal of Industrial Medicine, vol. 28, no. 2, 1995, pp. 167-84.
Kuempel ED, Stayner LT, Attfield MD, et al. Exposure-response analysis of mortality among coal miners in the United States. Am J Ind Med. 1995;28(2):167-84.
Kuempel, E. D., Stayner, L. T., Attfield, M. D., & Buncher, C. R. (1995). Exposure-response analysis of mortality among coal miners in the United States. American Journal of Industrial Medicine, 28(2), pp. 167-84.
Kuempel ED, et al. Exposure-response Analysis of Mortality Among Coal Miners in the United States. Am J Ind Med. 1995;28(2):167-84. PubMed PMID: 8585515.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Exposure-response analysis of mortality among coal miners in the United States. AU - Kuempel,E D, AU - Stayner,L T, AU - Attfield,M D, AU - Buncher,C R, PY - 1995/8/1/pubmed PY - 1995/8/1/medline PY - 1995/8/1/entrez SP - 167 EP - 84 JF - American journal of industrial medicine JO - Am. J. Ind. Med. VL - 28 IS - 2 N2 - The quantitative relationship between exposure to respirable coal mine dust and mortality from nonmalignant respiratory diseases was investigated in a study of 8,878 working male coal miners who were medically examined from 1969 to 1971 and followed to 1979. Exposure-related mortality was evaluated using Cox proportional hazards modeling for underlying or contributing causes of death and modified lifetable methods for underlying causes. For pneumoconiosis mortality, the lifetable analyses showed increasing standardized mortality ratios (SMRs) with increasing cumulative exposure category. Significant exposure-response relationships for mortality from pneumoconiosis (p < 0.001) and from chronic bronchitis or emphysema (p < 0.05) were observed in the proportional hazards models after controlling for age and smoking. No exposure-related increases in lung cancer or stomach cancer were observed. Pneumoconiosis mortality was found to vary significantly by the rank of coal dust to which miners were exposed. Miners exposed at or below the current U.S. coal dust standard of 2 mg/m3 over a working lifetime, based on these analyses, have an elevated risk of dying from pneumoconiosis or from chronic bronchitis or emphysema. SN - 0271-3586 UR - https://www.unboundmedicine.com/medline/citation/8585515/Exposure_response_analysis_of_mortality_among_coal_miners_in_the_United_States_ L2 - https://onlinelibrary.wiley.com/resolve/openurl?genre=article&amp;sid=nlm:pubmed&amp;issn=0271-3586&amp;date=1995&amp;volume=28&amp;issue=2&amp;spage=167 DB - PRIME DP - Unbound Medicine ER -