Tags

Type your tag names separated by a space and hit enter

Effects of infused sodium lactate on glucose and energy metabolism in healthy humans.
Diabete Metab. 1995 Dec; 21(5):345-52.DM

Abstract

To assess the effects of lactate on glucose metabolism, sodium lactate (20 mumol.kg-1.min-1) was infused into healthy subjects in basal conditions and during application of a hyperinsulinaemic (6 pmol.kg-1.min-1) euglycaemic clamp. Glucose rate of appearance (GRa) and disappearance (GRd) were measured from plasma dilution of infused U- 13C glucose, and glucose oxidation (G(ox)) from breath 13CO2 and plasma 13C glucose. In basal conditions, lactate infusion did not alter G(ox) (8.8 +/- 0.9 vs 9.2 +/- 1.1 mumol.kg-1.min-1), while GRa slightly decreased from 15.2 +/- 0.8 basal to 13.9 +/- 0.9 mumol.kg-1.min-1 after lactate (p < 0.05). During a hyperinsulinaemic clamp, hepatic glucose production was completely suppressed with or without lactate. Lactate decreased G(ox) from 17.1 +/- 0.4 to 13.4 +/- 1.2 mumol.kg-1.min-1 (p < 0.05), whereas GRd was unchanged (39.7 +/- 3.6 vs 45.6 +/- 2.6 mumol.kg-1.min-1. It is concluded that infusion of lactate in basal conditions does not increase GRa or interfere with peripheral glucose oxidation, and that during hyperinsulinaemia lactate decreases glucose oxidation but does not alter hepatic or peripheral insulin sensitivity.

Authors+Show Affiliations

Institut de physiologie, Lausanne, Switzerland.No affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Journal Article
Research Support, Non-U.S. Gov't

Language

eng

PubMed ID

8586151

Citation

Paquot, N, et al. "Effects of Infused Sodium Lactate On Glucose and Energy Metabolism in Healthy Humans." Diabete & Metabolisme, vol. 21, no. 5, 1995, pp. 345-52.
Paquot N, Schneiter P, Cayeux MC, et al. Effects of infused sodium lactate on glucose and energy metabolism in healthy humans. Diabete Metab. 1995;21(5):345-52.
Paquot, N., Schneiter, P., Cayeux, M. C., Chiolero, R., Temler, E., Jequier, E., & Tappy, L. (1995). Effects of infused sodium lactate on glucose and energy metabolism in healthy humans. Diabete & Metabolisme, 21(5), 345-52.
Paquot N, et al. Effects of Infused Sodium Lactate On Glucose and Energy Metabolism in Healthy Humans. Diabete Metab. 1995;21(5):345-52. PubMed PMID: 8586151.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Effects of infused sodium lactate on glucose and energy metabolism in healthy humans. AU - Paquot,N, AU - Schneiter,P, AU - Cayeux,M C, AU - Chiolero,R, AU - Temler,E, AU - Jequier,E, AU - Tappy,L, PY - 1995/12/1/pubmed PY - 2000/3/11/medline PY - 1995/12/1/entrez SP - 345 EP - 52 JF - Diabete & metabolisme JO - Diabete Metab VL - 21 IS - 5 N2 - To assess the effects of lactate on glucose metabolism, sodium lactate (20 mumol.kg-1.min-1) was infused into healthy subjects in basal conditions and during application of a hyperinsulinaemic (6 pmol.kg-1.min-1) euglycaemic clamp. Glucose rate of appearance (GRa) and disappearance (GRd) were measured from plasma dilution of infused U- 13C glucose, and glucose oxidation (G(ox)) from breath 13CO2 and plasma 13C glucose. In basal conditions, lactate infusion did not alter G(ox) (8.8 +/- 0.9 vs 9.2 +/- 1.1 mumol.kg-1.min-1), while GRa slightly decreased from 15.2 +/- 0.8 basal to 13.9 +/- 0.9 mumol.kg-1.min-1 after lactate (p < 0.05). During a hyperinsulinaemic clamp, hepatic glucose production was completely suppressed with or without lactate. Lactate decreased G(ox) from 17.1 +/- 0.4 to 13.4 +/- 1.2 mumol.kg-1.min-1 (p < 0.05), whereas GRd was unchanged (39.7 +/- 3.6 vs 45.6 +/- 2.6 mumol.kg-1.min-1. It is concluded that infusion of lactate in basal conditions does not increase GRa or interfere with peripheral glucose oxidation, and that during hyperinsulinaemia lactate decreases glucose oxidation but does not alter hepatic or peripheral insulin sensitivity. SN - 0338-1684 UR - https://www.unboundmedicine.com/medline/citation/8586151/Effects_of_infused_sodium_lactate_on_glucose_and_energy_metabolism_in_healthy_humans_ L2 - https://medlineplus.gov/bloodsugar.html DB - PRIME DP - Unbound Medicine ER -