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Modification of acute experimental autoimmune encephalomyelitis in the Lewis rat by oral administration of type 1 interferons.
J Interferon Cytokine Res 1995; 15(2):115-22JI

Abstract

The effect of orally administered type 1 interferons on the severity of acute experimental autoimmune encephalomyelitis (EAE), a T cell-mediated autoimmune disease, was examined by inoculation of Lewis rats with guinea pig myelin basic protein (GPMBP) and complete Freund's adjuvant. Rats were fed either rat species-specific or human recombinant type 1 interferon (IFN) or mock IFN daily for 7 days preceding immunization and for 21 days thereafter. There was a significant decrease in the clinical score and inflammatory foci in animals fed 5000 units IFN compared with mock-treated animals. There was a significant decrease in clinical score and number of inflammatory foci in spinal cord in animals fed orally 5000 units human recombinant IFN-alpha PO compared with SC 5000 units recombinant human IFN-alpha. Oral administration of type 1 interferon, as opposed to subcutaneous administration, inhibited the secretion of IFN-gamma from ConA-activated draining popliteal lymph node cells compared with mock-fed animals. These experiments demonstrate that acute EAE is more effectively inhibited by equivalent amounts of orally in contrast to parenterally administered IFN-alpha. These results suggest that type 1 IFNs are active by the oral route and have significant clinical and histologic effects in acute autoimmune disease.

Authors+Show Affiliations

Department of Neurology, University of Texas Health Science Center at Houston 77030, USA.No affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Comparative Study
Journal Article
Research Support, Non-U.S. Gov't

Language

eng

PubMed ID

8590314

Citation

Brod, S A., et al. "Modification of Acute Experimental Autoimmune Encephalomyelitis in the Lewis Rat By Oral Administration of Type 1 Interferons." Journal of Interferon & Cytokine Research : the Official Journal of the International Society for Interferon and Cytokine Research, vol. 15, no. 2, 1995, pp. 115-22.
Brod SA, Scott M, Burns DK, et al. Modification of acute experimental autoimmune encephalomyelitis in the Lewis rat by oral administration of type 1 interferons. J Interferon Cytokine Res. 1995;15(2):115-22.
Brod, S. A., Scott, M., Burns, D. K., & Phillips, J. T. (1995). Modification of acute experimental autoimmune encephalomyelitis in the Lewis rat by oral administration of type 1 interferons. Journal of Interferon & Cytokine Research : the Official Journal of the International Society for Interferon and Cytokine Research, 15(2), pp. 115-22.
Brod SA, et al. Modification of Acute Experimental Autoimmune Encephalomyelitis in the Lewis Rat By Oral Administration of Type 1 Interferons. J Interferon Cytokine Res. 1995;15(2):115-22. PubMed PMID: 8590314.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Modification of acute experimental autoimmune encephalomyelitis in the Lewis rat by oral administration of type 1 interferons. AU - Brod,S A, AU - Scott,M, AU - Burns,D K, AU - Phillips,J T, PY - 1995/2/1/pubmed PY - 1995/2/1/medline PY - 1995/2/1/entrez SP - 115 EP - 22 JF - Journal of interferon & cytokine research : the official journal of the International Society for Interferon and Cytokine Research JO - J. Interferon Cytokine Res. VL - 15 IS - 2 N2 - The effect of orally administered type 1 interferons on the severity of acute experimental autoimmune encephalomyelitis (EAE), a T cell-mediated autoimmune disease, was examined by inoculation of Lewis rats with guinea pig myelin basic protein (GPMBP) and complete Freund's adjuvant. Rats were fed either rat species-specific or human recombinant type 1 interferon (IFN) or mock IFN daily for 7 days preceding immunization and for 21 days thereafter. There was a significant decrease in the clinical score and inflammatory foci in animals fed 5000 units IFN compared with mock-treated animals. There was a significant decrease in clinical score and number of inflammatory foci in spinal cord in animals fed orally 5000 units human recombinant IFN-alpha PO compared with SC 5000 units recombinant human IFN-alpha. Oral administration of type 1 interferon, as opposed to subcutaneous administration, inhibited the secretion of IFN-gamma from ConA-activated draining popliteal lymph node cells compared with mock-fed animals. These experiments demonstrate that acute EAE is more effectively inhibited by equivalent amounts of orally in contrast to parenterally administered IFN-alpha. These results suggest that type 1 IFNs are active by the oral route and have significant clinical and histologic effects in acute autoimmune disease. SN - 1079-9907 UR - https://www.unboundmedicine.com/medline/citation/8590314/Modification_of_acute_experimental_autoimmune_encephalomyelitis_in_the_Lewis_rat_by_oral_administration_of_type_1_interferons_ L2 - https://www.liebertpub.com/doi/full/10.1089/jir.1995.15.115?url_ver=Z39.88-2003&rfr_id=ori:rid:crossref.org&rfr_dat=cr_pub=pubmed DB - PRIME DP - Unbound Medicine ER -