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Plasma lipids and lipoprotein alterations in tamoxifen-treated breast cancer women in relation to the menopausal status.
Cancer Biochem Biophys. 1995 Nov; 15(2):83-90.CB

Abstract

Plasma lipids and lipoprotein profiles were monitored in 72 postmenopausal and 29 premenopausal breast cancer women who were treated with tamoxifen (20 mg twice a day) for 6 months. The levels of total and free cholesterol and LDL cholesterol were markedly (P < 0.001 for each) decreased in 3 and 6 month tamoxifen-treated postmenopausal women than the baseline values of untreated breast cancer patients. On the contrary, plasma ester cholesterol, triglycerides, VLDL and HDL cholesterol levels were increased significantly in these patients. In the case of premenopausal women the lipid lowering potential of tamoxifen was markedly retarded. These results indicated that tamoxifen - treatment was more beneficial and estrogenic in postmenopausal women's lipids. In premenopausal breast cancer women, tamoxifen was antiestrogenic and less beneficial. Hence, the difference in plasma lipids and lipoprotein content was no greater among those receiving tamoxifen and baseline values of premeno - pausal women. These results indicate that tamoxifen-treatment has a more beneficial effect in postmenopausal women, with a likely reduction in cardiovascular disease, than in premenopausal subjects.

Authors+Show Affiliations

Department of Medical Biochemistry, University of Madras, India, USA.No affiliation info availableNo affiliation info available

Pub Type(s)

Comparative Study
Journal Article
Research Support, Non-U.S. Gov't

Language

eng

PubMed ID

8590439

Citation

Ilanchezhian, S, et al. "Plasma Lipids and Lipoprotein Alterations in Tamoxifen-treated Breast Cancer Women in Relation to the Menopausal Status." Cancer Biochemistry Biophysics, vol. 15, no. 2, 1995, pp. 83-90.
Ilanchezhian S, Thangaraju M, Sachdanandam P. Plasma lipids and lipoprotein alterations in tamoxifen-treated breast cancer women in relation to the menopausal status. Cancer Biochem Biophys. 1995;15(2):83-90.
Ilanchezhian, S., Thangaraju, M., & Sachdanandam, P. (1995). Plasma lipids and lipoprotein alterations in tamoxifen-treated breast cancer women in relation to the menopausal status. Cancer Biochemistry Biophysics, 15(2), 83-90.
Ilanchezhian S, Thangaraju M, Sachdanandam P. Plasma Lipids and Lipoprotein Alterations in Tamoxifen-treated Breast Cancer Women in Relation to the Menopausal Status. Cancer Biochem Biophys. 1995;15(2):83-90. PubMed PMID: 8590439.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Plasma lipids and lipoprotein alterations in tamoxifen-treated breast cancer women in relation to the menopausal status. AU - Ilanchezhian,S, AU - Thangaraju,M, AU - Sachdanandam,P, PY - 1995/11/1/pubmed PY - 1995/11/1/medline PY - 1995/11/1/entrez SP - 83 EP - 90 JF - Cancer biochemistry biophysics JO - Cancer Biochem. Biophys. VL - 15 IS - 2 N2 - Plasma lipids and lipoprotein profiles were monitored in 72 postmenopausal and 29 premenopausal breast cancer women who were treated with tamoxifen (20 mg twice a day) for 6 months. The levels of total and free cholesterol and LDL cholesterol were markedly (P < 0.001 for each) decreased in 3 and 6 month tamoxifen-treated postmenopausal women than the baseline values of untreated breast cancer patients. On the contrary, plasma ester cholesterol, triglycerides, VLDL and HDL cholesterol levels were increased significantly in these patients. In the case of premenopausal women the lipid lowering potential of tamoxifen was markedly retarded. These results indicated that tamoxifen - treatment was more beneficial and estrogenic in postmenopausal women's lipids. In premenopausal breast cancer women, tamoxifen was antiestrogenic and less beneficial. Hence, the difference in plasma lipids and lipoprotein content was no greater among those receiving tamoxifen and baseline values of premeno - pausal women. These results indicate that tamoxifen-treatment has a more beneficial effect in postmenopausal women, with a likely reduction in cardiovascular disease, than in premenopausal subjects. SN - 0305-7232 UR - https://www.unboundmedicine.com/medline/citation/8590439/Plasma_lipids_and_lipoprotein_alterations_in_tamoxifen_treated_breast_cancer_women_in_relation_to_the_menopausal_status_ L2 - http://www.diseaseinfosearch.org/result/960 DB - PRIME DP - Unbound Medicine ER -