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Influence of intravascular molecular weight of hydroxyethyl starch on platelets.
Eur J Haematol. 1996 Mar; 56(3):168-72.EJ

Abstract

Complications concerning the blood coagulation have been observed repeatedly after administration of highly substituted, high molecular weight hydroxyethyl starch (HES), but it has not been examined as to how intravascular molecular weight and degree of substitution of HES influence platelet number and volume after repeated administration. Thirty patients with cerebrovascular diseases were treated for 10 days with hemodilution. 500 to 1500 ml of HES 200/0.62(n=10), HES 200/0.5(n=10) or HES 40/0.5(n=10) were infused daily. During the first days, the number of platelets was not lowered beyond the dilution effect, but at the end of the therapy the number of platelets had increased in all 3 groups beyond the initial value. Platelet volume was lowered significantly in the 3 groups. HES 200/0.62 caused the largest drop in platelet volume (-10%, p<0.01). A possible explanation could be that HES macromolecules are attached to platelets or are phagocytized by them. The larger platelets are then broken down and, to compensate the loss, more thrombocytes are released. A correlation between the molecular weight of HES and the breakdown rate of the platelets can be suspected, because HES 200/0.62 has the highest intravascular mean molecular weight(121 kD) and the largest effect on platelet volume.

Authors+Show Affiliations

Dept. of Nurology, University of the Saarland, Homburg, Germany.No affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Comparative Study
Journal Article

Language

eng

PubMed ID

8598237

Citation

Treib, J, et al. "Influence of Intravascular Molecular Weight of Hydroxyethyl Starch On Platelets." European Journal of Haematology, vol. 56, no. 3, 1996, pp. 168-72.
Treib J, Haass A, Pindur G, et al. Influence of intravascular molecular weight of hydroxyethyl starch on platelets. Eur J Haematol. 1996;56(3):168-72.
Treib, J., Haass, A., Pindur, G., Treib, W., Wenzel, E., & Schimrigk, K. (1996). Influence of intravascular molecular weight of hydroxyethyl starch on platelets. European Journal of Haematology, 56(3), 168-72.
Treib J, et al. Influence of Intravascular Molecular Weight of Hydroxyethyl Starch On Platelets. Eur J Haematol. 1996;56(3):168-72. PubMed PMID: 8598237.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Influence of intravascular molecular weight of hydroxyethyl starch on platelets. AU - Treib,J, AU - Haass,A, AU - Pindur,G, AU - Treib,W, AU - Wenzel,E, AU - Schimrigk,K, PY - 1996/3/1/pubmed PY - 1996/3/1/medline PY - 1996/3/1/entrez SP - 168 EP - 72 JF - European journal of haematology JO - Eur J Haematol VL - 56 IS - 3 N2 - Complications concerning the blood coagulation have been observed repeatedly after administration of highly substituted, high molecular weight hydroxyethyl starch (HES), but it has not been examined as to how intravascular molecular weight and degree of substitution of HES influence platelet number and volume after repeated administration. Thirty patients with cerebrovascular diseases were treated for 10 days with hemodilution. 500 to 1500 ml of HES 200/0.62(n=10), HES 200/0.5(n=10) or HES 40/0.5(n=10) were infused daily. During the first days, the number of platelets was not lowered beyond the dilution effect, but at the end of the therapy the number of platelets had increased in all 3 groups beyond the initial value. Platelet volume was lowered significantly in the 3 groups. HES 200/0.62 caused the largest drop in platelet volume (-10%, p<0.01). A possible explanation could be that HES macromolecules are attached to platelets or are phagocytized by them. The larger platelets are then broken down and, to compensate the loss, more thrombocytes are released. A correlation between the molecular weight of HES and the breakdown rate of the platelets can be suspected, because HES 200/0.62 has the highest intravascular mean molecular weight(121 kD) and the largest effect on platelet volume. SN - 0902-4441 UR - https://www.unboundmedicine.com/medline/citation/8598237/Influence_of_intravascular_molecular_weight_of_hydroxyethyl_starch_on_platelets_ L2 - https://onlinelibrary.wiley.com/resolve/openurl?genre=article&amp;sid=nlm:pubmed&amp;issn=0902-4441&amp;date=1996&amp;volume=56&amp;issue=3&amp;spage=168 DB - PRIME DP - Unbound Medicine ER -