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Evaluation of a porous bovine collagen membrane bandage for management of wounds in horses.
Am J Vet Res. 1995 Dec; 56(12):1663-7.AJ

Abstract

OBJECTIVE

To evaluate the effect of a porous bovine-derived collagen membrane (PBCM) on the rates of wound healing, cellular events, presence of granulation tissue, and appearance at termination of the study in surgically created full-thickness cutaneous wounds of the distal portion of the extremities of horses.

DESIGN

Treated wounds (n = 12) received a PBCM dressing and control wounds were covered with a nonadherent dressing. Forelimbs and hind limbs were cross paired; the right forelimb and left hind limb always received the same dressing application, as did the left forelimb and right hind limb. Limbs pairs were then randomly assigned to 1 of the 2 dressings.

ANIMALS

Six healthy male horses (3 sexually intact, 3 geldings) ranging from 2 to 10 (mean, 6.5) years and weighing between 278 and 568 (mean, 408.5) kg were studied.

PROCEDURE

Full-thickness skin wounds (6.25 cm2) were created on the dorsal metatarsi and metacarpi of the experimental animals. A preformed PBCM dressing was evaluated in half the wounds (n = 12). Control wounds (n = 12) were dressed with a nonadherent gauze dressing. At each bandage change, wounds were subjectively assessed and were photographed, and measurements of horizontal and vertical wound dimensions were documented. Wound biopsy specimens obtained on days 2, 5, 7, 10, 21, and 31 were evaluated for presence of collagen, fibrin, inflammation, epithelium, and cellular elements of healing. Planar morphometry was used to determine total wound area and granulation area from the wound photographs. Percentage of contraction and epithelialization were calculated from these values. Linear regression analysis of the square root of the total wound area and the granulation area was performed. Wound area measurements were analyzed, using ANOVA for repeated measures. Regressions were compared, using covariance analysis and ANOVA. Significance was considered at P < 0.05.

RESULTS

Fibrin score, neutrophil score, and degree of inflammation were significantly greater in the PBCM-treated wounds. No significant differences in the total wound, epithelialized, or contraction areas were detected between the PBCM-treated and control (nonadherent-treated) wounds. Rates of wound healing were not statistically different between the 2 treatment groups, though they were significantly slower in the hind limbs, compared with the forelimbs. Scabs were formed more frequently in the PBCM-treated wounds.

CONCLUSIONS

Application of a porous collagen bandage was not detrimental to full-thickness cutaneous wound healing in horses.

Authors+Show Affiliations

Department of Clinical Sciences, College of Veterinary Medicine, Kansas State University, Manhattan 66506-5606, USA.No affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Journal Article
Research Support, Non-U.S. Gov't

Language

eng

PubMed ID

8599530

Citation

Yvorchuk-St Jean, K, et al. "Evaluation of a Porous Bovine Collagen Membrane Bandage for Management of Wounds in Horses." American Journal of Veterinary Research, vol. 56, no. 12, 1995, pp. 1663-7.
Yvorchuk-St Jean K, Gaughan E, St Jean G, et al. Evaluation of a porous bovine collagen membrane bandage for management of wounds in horses. Am J Vet Res. 1995;56(12):1663-7.
Yvorchuk-St Jean, K., Gaughan, E., St Jean, G., & Frank, R. (1995). Evaluation of a porous bovine collagen membrane bandage for management of wounds in horses. American Journal of Veterinary Research, 56(12), 1663-7.
Yvorchuk-St Jean K, et al. Evaluation of a Porous Bovine Collagen Membrane Bandage for Management of Wounds in Horses. Am J Vet Res. 1995;56(12):1663-7. PubMed PMID: 8599530.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Evaluation of a porous bovine collagen membrane bandage for management of wounds in horses. AU - Yvorchuk-St Jean,K, AU - Gaughan,E, AU - St Jean,G, AU - Frank,R, PY - 1995/12/1/pubmed PY - 1995/12/1/medline PY - 1995/12/1/entrez SP - 1663 EP - 7 JF - American journal of veterinary research JO - Am. J. Vet. Res. VL - 56 IS - 12 N2 - OBJECTIVE: To evaluate the effect of a porous bovine-derived collagen membrane (PBCM) on the rates of wound healing, cellular events, presence of granulation tissue, and appearance at termination of the study in surgically created full-thickness cutaneous wounds of the distal portion of the extremities of horses. DESIGN: Treated wounds (n = 12) received a PBCM dressing and control wounds were covered with a nonadherent dressing. Forelimbs and hind limbs were cross paired; the right forelimb and left hind limb always received the same dressing application, as did the left forelimb and right hind limb. Limbs pairs were then randomly assigned to 1 of the 2 dressings. ANIMALS: Six healthy male horses (3 sexually intact, 3 geldings) ranging from 2 to 10 (mean, 6.5) years and weighing between 278 and 568 (mean, 408.5) kg were studied. PROCEDURE: Full-thickness skin wounds (6.25 cm2) were created on the dorsal metatarsi and metacarpi of the experimental animals. A preformed PBCM dressing was evaluated in half the wounds (n = 12). Control wounds (n = 12) were dressed with a nonadherent gauze dressing. At each bandage change, wounds were subjectively assessed and were photographed, and measurements of horizontal and vertical wound dimensions were documented. Wound biopsy specimens obtained on days 2, 5, 7, 10, 21, and 31 were evaluated for presence of collagen, fibrin, inflammation, epithelium, and cellular elements of healing. Planar morphometry was used to determine total wound area and granulation area from the wound photographs. Percentage of contraction and epithelialization were calculated from these values. Linear regression analysis of the square root of the total wound area and the granulation area was performed. Wound area measurements were analyzed, using ANOVA for repeated measures. Regressions were compared, using covariance analysis and ANOVA. Significance was considered at P < 0.05. RESULTS: Fibrin score, neutrophil score, and degree of inflammation were significantly greater in the PBCM-treated wounds. No significant differences in the total wound, epithelialized, or contraction areas were detected between the PBCM-treated and control (nonadherent-treated) wounds. Rates of wound healing were not statistically different between the 2 treatment groups, though they were significantly slower in the hind limbs, compared with the forelimbs. Scabs were formed more frequently in the PBCM-treated wounds. CONCLUSIONS: Application of a porous collagen bandage was not detrimental to full-thickness cutaneous wound healing in horses. SN - 0002-9645 UR - https://www.unboundmedicine.com/medline/citation/8599530/Evaluation_of_a_porous_bovine_collagen_membrane_bandage_for_management_of_wounds_in_horses_ DB - PRIME DP - Unbound Medicine ER -