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Irritable bowel syndrome treatment using pinaverium bromide as a calcium channel blocker. A randomized double-blind placebo-controlled trial.
Acta Gastroenterol Latinoam. 1995; 25(3):137-44.AG

Abstract

BACKGROUND

Irritable bowel syndrome is one of the principal causes of days lost from work. As there has been no effective treatment up to now, sufferers turn to various doctors and try all sorts of medicines over extended periods that last for years. Thus irritable bowel syndrome has become a serious socio-economic problem that affects the family and the workplace.

METHODS

We conducted a randomized, double-blind, placebo-controlled trial among 40 consecutive irritable bowel syndrome patients (mean age: 31.4 +/- 1.8, range 17-52 year; females). Pinaverium bromide (50 mg) or placebo was taken orally t.i.d with food.

RESULTS

Pinaverium bromide diminished pain duration from several hours to a few minutes (P Text:nav2]Conclusions. Pinaverium bromide is safe, and produce a significant benefit in the quality of the patients life, hence may be a valuable drug for the treatment of irritable bowel syndrome patients.

Authors+Show Affiliations

Unidad de Medicina Experimental U-404-B Hospital General de México, México D.F., México.No affiliation info availableNo affiliation info available

Pub Type(s)

Clinical Trial
Journal Article
Randomized Controlled Trial

Language

eng

PubMed ID

8600700

Citation

Awad, R, et al. "Irritable Bowel Syndrome Treatment Using Pinaverium Bromide as a Calcium Channel Blocker. a Randomized Double-blind Placebo-controlled Trial." Acta Gastroenterologica Latinoamericana, vol. 25, no. 3, 1995, pp. 137-44.
Awad R, Dibildox M, Ortiz F. Irritable bowel syndrome treatment using pinaverium bromide as a calcium channel blocker. A randomized double-blind placebo-controlled trial. Acta Gastroenterol Latinoam. 1995;25(3):137-44.
Awad, R., Dibildox, M., & Ortiz, F. (1995). Irritable bowel syndrome treatment using pinaverium bromide as a calcium channel blocker. A randomized double-blind placebo-controlled trial. Acta Gastroenterologica Latinoamericana, 25(3), 137-44.
Awad R, Dibildox M, Ortiz F. Irritable Bowel Syndrome Treatment Using Pinaverium Bromide as a Calcium Channel Blocker. a Randomized Double-blind Placebo-controlled Trial. Acta Gastroenterol Latinoam. 1995;25(3):137-44. PubMed PMID: 8600700.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Irritable bowel syndrome treatment using pinaverium bromide as a calcium channel blocker. A randomized double-blind placebo-controlled trial. AU - Awad,R, AU - Dibildox,M, AU - Ortiz,F, PY - 1995/1/1/pubmed PY - 1995/1/1/medline PY - 1995/1/1/entrez SP - 137 EP - 44 JF - Acta gastroenterologica Latinoamericana JO - Acta Gastroenterol Latinoam VL - 25 IS - 3 N2 - BACKGROUND: Irritable bowel syndrome is one of the principal causes of days lost from work. As there has been no effective treatment up to now, sufferers turn to various doctors and try all sorts of medicines over extended periods that last for years. Thus irritable bowel syndrome has become a serious socio-economic problem that affects the family and the workplace. METHODS: We conducted a randomized, double-blind, placebo-controlled trial among 40 consecutive irritable bowel syndrome patients (mean age: 31.4 +/- 1.8, range 17-52 year; females). Pinaverium bromide (50 mg) or placebo was taken orally t.i.d with food. RESULTS: Pinaverium bromide diminished pain duration from several hours to a few minutes (P Text:nav2]Conclusions. Pinaverium bromide is safe, and produce a significant benefit in the quality of the patients life, hence may be a valuable drug for the treatment of irritable bowel syndrome patients. SN - 0300-9033 UR - https://www.unboundmedicine.com/medline/citation/8600700/Irritable_bowel_syndrome_treatment_using_pinaverium_bromide_as_a_calcium_channel_blocker__A_randomized_double_blind_placebo_controlled_trial_ L2 - http://www.diseaseinfosearch.org/result/3876 DB - PRIME DP - Unbound Medicine ER -