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Red wine consumption does not affect oxidizability of low-density lipoproteins in volunteers.
Am J Clin Nutr. 1996 Mar; 63(3):329-34.AJ

Abstract

Phenolic compounds in red wine may protect low-density lipoproteins (LDL) against oxidative modification, thereby reducing the risk of cardiovascular morbidity. However, in vivo data are scarce. We gave 13 healthy volunteers 550 mL red wine and another 11 volunteers white wine for 4 wk in a randomized double-blind trial. Interference by alcoholic components of wine was eliminated by reducing the alcohol content to 3.5% Red wine did not affect the susceptibility of LDL to Cu2+ -mediated oxidative modification [lag time before and after red wine drinking (chi +/- SD) 61.8 +/- 7.7 and 62.7 +/- 11.8 min, respectively; lag time before and after white wine drinking: 64.5 +/- 10.4 and 63.3 +/- 10.8 min, respectively]. Concentrations of the antioxidants urate, vitamin C, and glutathione in plasma and of vitamin E and ubiquinol-10 in LDL were also unchanged after either red or white wine consumption. The results of this study do not show a beneficial effect of red wine consumption on LDL oxidation.

Authors+Show Affiliations

Department of Medicine, Divison of General Internal Medicine, University Hospital Nijmegen, The Wageningen Agricultural University, Netherlands.No affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Clinical Trial
Journal Article
Randomized Controlled Trial
Research Support, Non-U.S. Gov't

Language

eng

PubMed ID

8602588

Citation

de Rijke, Y B., et al. "Red Wine Consumption Does Not Affect Oxidizability of Low-density Lipoproteins in Volunteers." The American Journal of Clinical Nutrition, vol. 63, no. 3, 1996, pp. 329-34.
de Rijke YB, Demacker PN, Assen NA, et al. Red wine consumption does not affect oxidizability of low-density lipoproteins in volunteers. Am J Clin Nutr. 1996;63(3):329-34.
de Rijke, Y. B., Demacker, P. N., Assen, N. A., Sloots, L. M., Katan, M. B., & Stalenhoef, A. F. (1996). Red wine consumption does not affect oxidizability of low-density lipoproteins in volunteers. The American Journal of Clinical Nutrition, 63(3), 329-34.
de Rijke YB, et al. Red Wine Consumption Does Not Affect Oxidizability of Low-density Lipoproteins in Volunteers. Am J Clin Nutr. 1996;63(3):329-34. PubMed PMID: 8602588.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Red wine consumption does not affect oxidizability of low-density lipoproteins in volunteers. AU - de Rijke,Y B, AU - Demacker,P N, AU - Assen,N A, AU - Sloots,L M, AU - Katan,M B, AU - Stalenhoef,A F, PY - 1996/3/1/pubmed PY - 1996/3/1/medline PY - 1996/3/1/entrez SP - 329 EP - 34 JF - The American journal of clinical nutrition JO - Am J Clin Nutr VL - 63 IS - 3 N2 - Phenolic compounds in red wine may protect low-density lipoproteins (LDL) against oxidative modification, thereby reducing the risk of cardiovascular morbidity. However, in vivo data are scarce. We gave 13 healthy volunteers 550 mL red wine and another 11 volunteers white wine for 4 wk in a randomized double-blind trial. Interference by alcoholic components of wine was eliminated by reducing the alcohol content to 3.5% Red wine did not affect the susceptibility of LDL to Cu2+ -mediated oxidative modification [lag time before and after red wine drinking (chi +/- SD) 61.8 +/- 7.7 and 62.7 +/- 11.8 min, respectively; lag time before and after white wine drinking: 64.5 +/- 10.4 and 63.3 +/- 10.8 min, respectively]. Concentrations of the antioxidants urate, vitamin C, and glutathione in plasma and of vitamin E and ubiquinol-10 in LDL were also unchanged after either red or white wine consumption. The results of this study do not show a beneficial effect of red wine consumption on LDL oxidation. SN - 0002-9165 UR - https://www.unboundmedicine.com/medline/citation/8602588/Red_wine_consumption_does_not_affect_oxidizability_of_low_density_lipoproteins_in_volunteers_ L2 - https://academic.oup.com/ajcn/article-lookup/doi/10.1093/ajcn/63.3.329 DB - PRIME DP - Unbound Medicine ER -