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Effects of a diet low in copper on copper-status indicators in postmenopausal women.
Am J Clin Nutr 1996; 63(3):358-64AJ

Abstract

To study the effects of low copper intake in older individuals, 12 postmenopausal women, aged 63.1 +/- 8.8 y, were fed a diet containing 9 micromol (0.57 mg) Cu/d for 105 d, followed by a copper-repletion period of 35 d during which the diet was supplemented with 31.5 micromol (2.0 mg) Cu/d. Plasma copper and ceruloplasmin did not change significantly during copper depletion but ceruloplasmin decreased during copper repletion. Erythrocyte superoxide dismutase activity dropped significantly during low copper intake from 3450 to 2600 U/g hemoglobin, but did not increase during copper repletion. Platelet cytochrome c oxidase activity changed significantly (P<0.0001) from 1740 to 810 U/g protein during copper depletion, then increased to 1000 U/g protein during copper repletion. Erythrocyte glutathione peroxidase activity responded similarly. Clotting factor VIII activity increased significantly during copper depletion, then dropped during copper repletion. Low copper intakes did not induce the changes in serum cholesterol and hematology generally found in copper-deficient animal models. These results indicate that a paradigm shift may be needed in evaluating copper status in adult humans. Sensitive indicators of copper include functional activities of platelet cytochrome c oxidase, platelet copper, glutathione peroxidase, and clotting factor VIII. Plasma copper, ceruloplasmin, and cholesterol are relatively insensitive indicators. Also, the recovery from mild copper depletion may require more aggressive intervention tha 2 mg Cu/d for 35 d.

Authors+Show Affiliations

United States Department of Agriculture, Agricultural Research Center, Grand Forks Human Nutrition Research Center, ND, USA.No affiliation info available

Pub Type(s)

Journal Article

Language

eng

PubMed ID

8602593

Citation

Milne, D B., and F H. Nielsen. "Effects of a Diet Low in Copper On Copper-status Indicators in Postmenopausal Women." The American Journal of Clinical Nutrition, vol. 63, no. 3, 1996, pp. 358-64.
Milne DB, Nielsen FH. Effects of a diet low in copper on copper-status indicators in postmenopausal women. Am J Clin Nutr. 1996;63(3):358-64.
Milne, D. B., & Nielsen, F. H. (1996). Effects of a diet low in copper on copper-status indicators in postmenopausal women. The American Journal of Clinical Nutrition, 63(3), pp. 358-64.
Milne DB, Nielsen FH. Effects of a Diet Low in Copper On Copper-status Indicators in Postmenopausal Women. Am J Clin Nutr. 1996;63(3):358-64. PubMed PMID: 8602593.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Effects of a diet low in copper on copper-status indicators in postmenopausal women. AU - Milne,D B, AU - Nielsen,F H, PY - 1996/3/1/pubmed PY - 1996/3/1/medline PY - 1996/3/1/entrez SP - 358 EP - 64 JF - The American journal of clinical nutrition JO - Am. J. Clin. Nutr. VL - 63 IS - 3 N2 - To study the effects of low copper intake in older individuals, 12 postmenopausal women, aged 63.1 +/- 8.8 y, were fed a diet containing 9 micromol (0.57 mg) Cu/d for 105 d, followed by a copper-repletion period of 35 d during which the diet was supplemented with 31.5 micromol (2.0 mg) Cu/d. Plasma copper and ceruloplasmin did not change significantly during copper depletion but ceruloplasmin decreased during copper repletion. Erythrocyte superoxide dismutase activity dropped significantly during low copper intake from 3450 to 2600 U/g hemoglobin, but did not increase during copper repletion. Platelet cytochrome c oxidase activity changed significantly (P<0.0001) from 1740 to 810 U/g protein during copper depletion, then increased to 1000 U/g protein during copper repletion. Erythrocyte glutathione peroxidase activity responded similarly. Clotting factor VIII activity increased significantly during copper depletion, then dropped during copper repletion. Low copper intakes did not induce the changes in serum cholesterol and hematology generally found in copper-deficient animal models. These results indicate that a paradigm shift may be needed in evaluating copper status in adult humans. Sensitive indicators of copper include functional activities of platelet cytochrome c oxidase, platelet copper, glutathione peroxidase, and clotting factor VIII. Plasma copper, ceruloplasmin, and cholesterol are relatively insensitive indicators. Also, the recovery from mild copper depletion may require more aggressive intervention tha 2 mg Cu/d for 35 d. SN - 0002-9165 UR - https://www.unboundmedicine.com/medline/citation/8602593/Effects_of_a_diet_low_in_copper_on_copper_status_indicators_in_postmenopausal_women_ L2 - https://academic.oup.com/ajcn/article-lookup/doi/10.1093/ajcn/63.3.358 DB - PRIME DP - Unbound Medicine ER -