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Abeta-peptide length and apolipoprotein E genotype in Alzheimer's disease.
Ann Neurol 1996; 39(3):395-9AN

Abstract

Apolipoprotein E (ApoE) epsilon4 allele, a risk factor for the development of Alzheimer's disease (AD), is associated with increased amyloid deposition. We examined cerebral cortex in 68 AD cases using antibodies to beta-amyloid (Abeta) peptides of different length (Abeta1-40 and Abeta1-42) and found that the increased plaque frequency observed with epsilon4 genotypes may be largely attributed to an increase in Abeta1-40-positive plaques. Indeed, both the number of Abeta1-40-positive plaques, as well as the ratio of Abeta1-40/Abeta1-42-positive plaques, increased with epsilon4 dosage. In contrast, the frequency of Abeta1-42-immunoreactive plaques was similar for epsilon3/epsilon3, epsilon3/epsilon4, and epsilon4/epsilon4 genotypes. ApoE may influence Abeta1 length by facilitating Abeta1-40 deposition onto Abeta1-42-seeded plaques or by modulating the activity of a putative carboxypeptidase that forms Abeta1-40 from Abeta1-42 in situ.

Authors+Show Affiliations

VA Medical Center, Decatur, Georgia 30033, USA.No affiliation info availableNo affiliation info available

Pub Type(s)

Journal Article

Language

eng

PubMed ID

8602762

Citation

Gearing, M, et al. "Abeta-peptide Length and Apolipoprotein E Genotype in Alzheimer's Disease." Annals of Neurology, vol. 39, no. 3, 1996, pp. 395-9.
Gearing M, Mori H, Mirra SS. Abeta-peptide length and apolipoprotein E genotype in Alzheimer's disease. Ann Neurol. 1996;39(3):395-9.
Gearing, M., Mori, H., & Mirra, S. S. (1996). Abeta-peptide length and apolipoprotein E genotype in Alzheimer's disease. Annals of Neurology, 39(3), pp. 395-9.
Gearing M, Mori H, Mirra SS. Abeta-peptide Length and Apolipoprotein E Genotype in Alzheimer's Disease. Ann Neurol. 1996;39(3):395-9. PubMed PMID: 8602762.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Abeta-peptide length and apolipoprotein E genotype in Alzheimer's disease. AU - Gearing,M, AU - Mori,H, AU - Mirra,S S, PY - 1996/3/1/pubmed PY - 1996/3/1/medline PY - 1996/3/1/entrez SP - 395 EP - 9 JF - Annals of neurology JO - Ann. Neurol. VL - 39 IS - 3 N2 - Apolipoprotein E (ApoE) epsilon4 allele, a risk factor for the development of Alzheimer's disease (AD), is associated with increased amyloid deposition. We examined cerebral cortex in 68 AD cases using antibodies to beta-amyloid (Abeta) peptides of different length (Abeta1-40 and Abeta1-42) and found that the increased plaque frequency observed with epsilon4 genotypes may be largely attributed to an increase in Abeta1-40-positive plaques. Indeed, both the number of Abeta1-40-positive plaques, as well as the ratio of Abeta1-40/Abeta1-42-positive plaques, increased with epsilon4 dosage. In contrast, the frequency of Abeta1-42-immunoreactive plaques was similar for epsilon3/epsilon3, epsilon3/epsilon4, and epsilon4/epsilon4 genotypes. ApoE may influence Abeta1 length by facilitating Abeta1-40 deposition onto Abeta1-42-seeded plaques or by modulating the activity of a putative carboxypeptidase that forms Abeta1-40 from Abeta1-42 in situ. SN - 0364-5134 UR - https://www.unboundmedicine.com/medline/citation/8602762/Abeta_peptide_length_and_apolipoprotein_E_genotype_in_Alzheimer's_disease_ L2 - https://onlinelibrary.wiley.com/resolve/openurl?genre=article&sid=nlm:pubmed&issn=0364-5134&date=1996&volume=39&issue=3&spage=395 DB - PRIME DP - Unbound Medicine ER -