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Alanyl-glutamine dipeptide-supplemented parenteral nutrition improves intestinal metabolism and prevents increased permeability in rats.
Ann Surg. 1996 Mar; 223(3):334-41.AnnS

Abstract

OBJECTIVE

The authors determined the effects of alanyl-glutamine-supplemented total parenteral nutrition (TPN) on mucosal metabolism, integrity, and permeability of the small intestine in rats.

METHODS

Male Sprague-Dawley rats were randomized to receive TPN supplemented with a conventional amino acids mixture (STD group) or the same solution supplemented with alanyl-glutamine; both solutions were isocaloric and isonitrogenous. On the seventh day of TPN, D-xylose and fluorescein isothiocyanate (FITC)-dextran were administered orally. One hour later, superior mesenteric vein (SMV) D-xylose and plasma FITC-dextran concentration were measured. Intestinal blood flow and calculated intestinal substrates flux were measured with ultrasonic transit time flowmetery.

RESULTS

Plasma FITC-dextran increased significantly in the STD group. Intestinal blood flow and SMV D-xylose concentration did not differ between the groups. Mucosa weight, villus height, mucosal wall thickness, mucosal protein, and DNA and RNA content in jejunal mucosa were significantly increased in the alanyl-glutamine group. Jejunal mucosal glutaminase activity and net intestinal uptake of glutamine (glutamine flux) were significantly higher in the alanyl-glutamine group as compared with the STD group.

CONCLUSION

Addition of alanyl-glutamine dipeptide to the TPN solution improves intestinal glutamine metabolism and prevents mucosal atrophy and deterioration of permeability.

Authors+Show Affiliations

Department of Pediatric Surgery, Osaka University Medical School, Japan.No affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Journal Article

Language

eng

PubMed ID

8604914

Citation

Haque, S M., et al. "Alanyl-glutamine Dipeptide-supplemented Parenteral Nutrition Improves Intestinal Metabolism and Prevents Increased Permeability in Rats." Annals of Surgery, vol. 223, no. 3, 1996, pp. 334-41.
Haque SM, Chen K, Usui N, et al. Alanyl-glutamine dipeptide-supplemented parenteral nutrition improves intestinal metabolism and prevents increased permeability in rats. Ann Surg. 1996;223(3):334-41.
Haque, S. M., Chen, K., Usui, N., Iiboshi, Y., Okuyama, H., Masunari, A., Cui, L., Nezu, R., Takagi, Y., & Okada, A. (1996). Alanyl-glutamine dipeptide-supplemented parenteral nutrition improves intestinal metabolism and prevents increased permeability in rats. Annals of Surgery, 223(3), 334-41.
Haque SM, et al. Alanyl-glutamine Dipeptide-supplemented Parenteral Nutrition Improves Intestinal Metabolism and Prevents Increased Permeability in Rats. Ann Surg. 1996;223(3):334-41. PubMed PMID: 8604914.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Alanyl-glutamine dipeptide-supplemented parenteral nutrition improves intestinal metabolism and prevents increased permeability in rats. AU - Haque,S M, AU - Chen,K, AU - Usui,N, AU - Iiboshi,Y, AU - Okuyama,H, AU - Masunari,A, AU - Cui,L, AU - Nezu,R, AU - Takagi,Y, AU - Okada,A, PY - 1996/3/1/pubmed PY - 1996/3/1/medline PY - 1996/3/1/entrez SP - 334 EP - 41 JF - Annals of surgery JO - Ann Surg VL - 223 IS - 3 N2 - OBJECTIVE: The authors determined the effects of alanyl-glutamine-supplemented total parenteral nutrition (TPN) on mucosal metabolism, integrity, and permeability of the small intestine in rats. METHODS: Male Sprague-Dawley rats were randomized to receive TPN supplemented with a conventional amino acids mixture (STD group) or the same solution supplemented with alanyl-glutamine; both solutions were isocaloric and isonitrogenous. On the seventh day of TPN, D-xylose and fluorescein isothiocyanate (FITC)-dextran were administered orally. One hour later, superior mesenteric vein (SMV) D-xylose and plasma FITC-dextran concentration were measured. Intestinal blood flow and calculated intestinal substrates flux were measured with ultrasonic transit time flowmetery. RESULTS: Plasma FITC-dextran increased significantly in the STD group. Intestinal blood flow and SMV D-xylose concentration did not differ between the groups. Mucosa weight, villus height, mucosal wall thickness, mucosal protein, and DNA and RNA content in jejunal mucosa were significantly increased in the alanyl-glutamine group. Jejunal mucosal glutaminase activity and net intestinal uptake of glutamine (glutamine flux) were significantly higher in the alanyl-glutamine group as compared with the STD group. CONCLUSION: Addition of alanyl-glutamine dipeptide to the TPN solution improves intestinal glutamine metabolism and prevents mucosal atrophy and deterioration of permeability. SN - 0003-4932 UR - https://www.unboundmedicine.com/medline/citation/8604914/Alanyl_glutamine_dipeptide_supplemented_parenteral_nutrition_improves_intestinal_metabolism_and_prevents_increased_permeability_in_rats_ L2 - https://Insights.ovid.com/pubmed?pmid=8604914 DB - PRIME DP - Unbound Medicine ER -