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Characteristics of diaphragm muscle fibre types in hibernating squirrels.
Respir Physiol 1995; 101(3):301-9RP

Abstract

Muscle samples from the diaphragms of 7 full-awake (FA), 10 winter-awake (WA), and 8 hibernating (H) squirrels (Spermophilus lateralis) were quick frozen, sectioned and processed for NADH-TR reaction end-product and myofibrillar-ATPase. Both WA and H squirrels showed small increases in diaphragm weight, reductions in body weight, and hence, significant increases in the diaphragm weight to body weight ratio compared to FA squirrels. They also showed increases in muscle fibre type cross-sectional areas and in the oxidative capacity of type 2b fibres as well as a reduction in capillary density. Furthermore, there also was an increase in the proportion of type 2b fibres in the diaphragm of the H squirrels. Thus, despite the dramatically reduced ventilation associated with hibernation, H squirrels exhibited (1) hypertrophy of the diaphragm which may represent an adaptive response that enables them to work against a stiffer chest wall, and (2) an increased oxidative capacity which enables them to fuel this with fat.

Authors+Show Affiliations

School of Rehabilitation Sciences, University of British Columbia, Vancouver, Canada. wdreid@unixg.ubc.ca.No affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Comparative Study
Journal Article
Research Support, Non-U.S. Gov't

Language

eng

PubMed ID

8607002

Citation

Reid, W D., et al. "Characteristics of Diaphragm Muscle Fibre Types in Hibernating Squirrels." Respiration Physiology, vol. 101, no. 3, 1995, pp. 301-9.
Reid WD, Ng A, Wilton R, et al. Characteristics of diaphragm muscle fibre types in hibernating squirrels. Respir Physiol. 1995;101(3):301-9.
Reid, W. D., Ng, A., Wilton, R., & Milsom, W. K. (1995). Characteristics of diaphragm muscle fibre types in hibernating squirrels. Respiration Physiology, 101(3), pp. 301-9.
Reid WD, et al. Characteristics of Diaphragm Muscle Fibre Types in Hibernating Squirrels. Respir Physiol. 1995;101(3):301-9. PubMed PMID: 8607002.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Characteristics of diaphragm muscle fibre types in hibernating squirrels. AU - Reid,W D, AU - Ng,A, AU - Wilton,R, AU - Milsom,W K, PY - 1995/9/1/pubmed PY - 1995/9/1/medline PY - 1995/9/1/entrez SP - 301 EP - 9 JF - Respiration physiology JO - Respir Physiol VL - 101 IS - 3 N2 - Muscle samples from the diaphragms of 7 full-awake (FA), 10 winter-awake (WA), and 8 hibernating (H) squirrels (Spermophilus lateralis) were quick frozen, sectioned and processed for NADH-TR reaction end-product and myofibrillar-ATPase. Both WA and H squirrels showed small increases in diaphragm weight, reductions in body weight, and hence, significant increases in the diaphragm weight to body weight ratio compared to FA squirrels. They also showed increases in muscle fibre type cross-sectional areas and in the oxidative capacity of type 2b fibres as well as a reduction in capillary density. Furthermore, there also was an increase in the proportion of type 2b fibres in the diaphragm of the H squirrels. Thus, despite the dramatically reduced ventilation associated with hibernation, H squirrels exhibited (1) hypertrophy of the diaphragm which may represent an adaptive response that enables them to work against a stiffer chest wall, and (2) an increased oxidative capacity which enables them to fuel this with fat. SN - 0034-5687 UR - https://www.unboundmedicine.com/medline/citation/8607002/Characteristics_of_diaphragm_muscle_fibre_types_in_hibernating_squirrels_ L2 - https://linkinghub.elsevier.com/retrieve/pii/003456879500036D DB - PRIME DP - Unbound Medicine ER -