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Calcium, vitamin D, and dairy foods and the occurrence of colon cancer in men.

Abstract

To examine the associations between intakes of calcium, Vitamin D, and dairy foods and the risk of colon cancer, the authors analyzed data from a prospective study of 47,935 US male professionals, 40-75 years of age and free of cancer in 1986. Within this cohort, 203 new cases of colon cancer were documented between 1986 and 1992. After adjusting for age and total energy intake, the authors found that the intake of calcium from foods and supplements was inversely associated with colon cancer risk (relative risk (RR) = 0.58, 95% confidence interval (CI) 0.39-087 between high and low intakes of calcium). However, after adjusting for confounding variables, they found that the trend was no longer statistically significant (p = 0.22), and the relative risk for the highest quintile group of intake was attenuated: 0.75 (95% CI 0.48-1.15). Similar results were observed for total vitamin D intake; the age- and energy-adjusted relative risk was 0.54% (95% CI 0/34-0/85) for the highest versus lowest quintile group, and this was attenuated in the multivariate model (RR = 0.66, 95% CI 0.42-1.05). The inverse association was weaker for dietary vitamin D (RR highest vs. lowest quintile = 0.88. 95% CI 0.54-1.42) and strongest for vitamin D arising from vitamin supplements (RR = 0.48, 95% CI 0.22-1.02). Thus, it is possible that other components of multivitamin use rather than vitamin D accounted for the reduction in risk. Consumption of milk and fermented dairy products was not significantly associated with the risk of colon cancer; individuals consuming two or more glasses of "whole" or skim milk per day had a relative risk of 1.09 (95% CI 0.69-1.72), compared with those who consumed "whole or skim milk less than once a month. These prospective data do not support the hypothesis that calcium intake is strongly protective against colon cancer risk, although a modest association cannot be excluded.

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  • Authors+Show Affiliations

    ,

    Department of Nutrition, Harvard School of Public Health, Boston, MA 02115, USA.

    , , , , , , ,

    Source

    American journal of epidemiology 143:9 1996 May 01 pg 907-17

    MeSH

    Adult
    Aged
    Calcium, Dietary
    Colonic Neoplasms
    Confounding Factors (Epidemiology)
    Dairy Products
    Health Personnel
    Humans
    Incidence
    Male
    Middle Aged
    Multivariate Analysis
    Prospective Studies
    Risk
    Risk Factors
    Surveys and Questionnaires
    United States
    Vitamin D

    Pub Type(s)

    Journal Article
    Research Support, Non-U.S. Gov't
    Research Support, U.S. Gov't, P.H.S.

    Language

    eng

    PubMed ID

    8610704

    Citation

    Kearney, J, et al. "Calcium, Vitamin D, and Dairy Foods and the Occurrence of Colon Cancer in Men." American Journal of Epidemiology, vol. 143, no. 9, 1996, pp. 907-17.
    Kearney J, Giovannucci E, Rimm EB, et al. Calcium, vitamin D, and dairy foods and the occurrence of colon cancer in men. Am J Epidemiol. 1996;143(9):907-17.
    Kearney, J., Giovannucci, E., Rimm, E. B., Ascherio, A., Stampfer, M. J., Colditz, G. A., ... Willett, W. C. (1996). Calcium, vitamin D, and dairy foods and the occurrence of colon cancer in men. American Journal of Epidemiology, 143(9), pp. 907-17.
    Kearney J, et al. Calcium, Vitamin D, and Dairy Foods and the Occurrence of Colon Cancer in Men. Am J Epidemiol. 1996 May 1;143(9):907-17. PubMed PMID: 8610704.
    * Article titles in AMA citation format should be in sentence-case
    TY - JOUR T1 - Calcium, vitamin D, and dairy foods and the occurrence of colon cancer in men. AU - Kearney,J, AU - Giovannucci,E, AU - Rimm,E B, AU - Ascherio,A, AU - Stampfer,M J, AU - Colditz,G A, AU - Wing,A, AU - Kampman,E, AU - Willett,W C, PY - 1996/5/1/pubmed PY - 1996/5/1/medline PY - 1996/5/1/entrez SP - 907 EP - 17 JF - American journal of epidemiology JO - Am. J. Epidemiol. VL - 143 IS - 9 N2 - To examine the associations between intakes of calcium, Vitamin D, and dairy foods and the risk of colon cancer, the authors analyzed data from a prospective study of 47,935 US male professionals, 40-75 years of age and free of cancer in 1986. Within this cohort, 203 new cases of colon cancer were documented between 1986 and 1992. After adjusting for age and total energy intake, the authors found that the intake of calcium from foods and supplements was inversely associated with colon cancer risk (relative risk (RR) = 0.58, 95% confidence interval (CI) 0.39-087 between high and low intakes of calcium). However, after adjusting for confounding variables, they found that the trend was no longer statistically significant (p = 0.22), and the relative risk for the highest quintile group of intake was attenuated: 0.75 (95% CI 0.48-1.15). Similar results were observed for total vitamin D intake; the age- and energy-adjusted relative risk was 0.54% (95% CI 0/34-0/85) for the highest versus lowest quintile group, and this was attenuated in the multivariate model (RR = 0.66, 95% CI 0.42-1.05). The inverse association was weaker for dietary vitamin D (RR highest vs. lowest quintile = 0.88. 95% CI 0.54-1.42) and strongest for vitamin D arising from vitamin supplements (RR = 0.48, 95% CI 0.22-1.02). Thus, it is possible that other components of multivitamin use rather than vitamin D accounted for the reduction in risk. Consumption of milk and fermented dairy products was not significantly associated with the risk of colon cancer; individuals consuming two or more glasses of "whole" or skim milk per day had a relative risk of 1.09 (95% CI 0.69-1.72), compared with those who consumed "whole or skim milk less than once a month. These prospective data do not support the hypothesis that calcium intake is strongly protective against colon cancer risk, although a modest association cannot be excluded. SN - 0002-9262 UR - https://www.unboundmedicine.com/medline/citation/8610704/Calcium_vitamin_D_and_dairy_foods_and_the_occurrence_of_colon_cancer_in_men_ L2 - https://academic.oup.com/aje/article-lookup/doi/10.1093/oxfordjournals.aje.a008834 DB - PRIME DP - Unbound Medicine ER -