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Pernicious anaemia and cancer risk in Denmark.
Br J Cancer 1996; 73(8):998-1000BJ

Abstract

A cohort of 5072 patients with pernicious anaemia was identified in the Danish Hospital Discharge Register from 1977 to 1989 and, through linkage to the Danish Cancer Registry, the occurrence of cancer in the cohort was determined up to 1991. Observed numbers of cancer cases during 1-15 years of follow-up were compared with expected numbers based on national incidence rates. Besides the well-established increased risk for stomach cancer, the analysis also revealed a 2-fold increase in the relative risk for cancer of the buccal cavity and pharynx among pernicious anaemia patients in accordance with previous studies; previously reported elevated risks for other digestive tract cancers were not confirmed. There was a non-significantly increased risk for lymphatic and haematological malignancy but the risk tended to disappear after 5 years of follow-up, indicating a possible selection bias. Decreased risks for cervical cancer and non-melanoma skin cancer were also seen.

Authors+Show Affiliations

Danish Cancer Society, Division for Cancer Epidemiology, Copenhagen O, Denmark.No affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Journal Article
Research Support, Non-U.S. Gov't
Research Support, U.S. Gov't, P.H.S.

Language

eng

PubMed ID

8611439

Citation

Mellemkjaer, L, et al. "Pernicious Anaemia and Cancer Risk in Denmark." British Journal of Cancer, vol. 73, no. 8, 1996, pp. 998-1000.
Mellemkjaer L, Gridley G, Møller H, et al. Pernicious anaemia and cancer risk in Denmark. Br J Cancer. 1996;73(8):998-1000.
Mellemkjaer, L., Gridley, G., Møller, H., Hsing, A. W., Linet, M. S., Brinton, L. A., & Olsen, J. H. (1996). Pernicious anaemia and cancer risk in Denmark. British Journal of Cancer, 73(8), pp. 998-1000.
Mellemkjaer L, et al. Pernicious Anaemia and Cancer Risk in Denmark. Br J Cancer. 1996;73(8):998-1000. PubMed PMID: 8611439.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Pernicious anaemia and cancer risk in Denmark. AU - Mellemkjaer,L, AU - Gridley,G, AU - Møller,H, AU - Hsing,A W, AU - Linet,M S, AU - Brinton,L A, AU - Olsen,J H, PY - 1996/4/1/pubmed PY - 1996/4/1/medline PY - 1996/4/1/entrez SP - 998 EP - 1000 JF - British journal of cancer JO - Br. J. Cancer VL - 73 IS - 8 N2 - A cohort of 5072 patients with pernicious anaemia was identified in the Danish Hospital Discharge Register from 1977 to 1989 and, through linkage to the Danish Cancer Registry, the occurrence of cancer in the cohort was determined up to 1991. Observed numbers of cancer cases during 1-15 years of follow-up were compared with expected numbers based on national incidence rates. Besides the well-established increased risk for stomach cancer, the analysis also revealed a 2-fold increase in the relative risk for cancer of the buccal cavity and pharynx among pernicious anaemia patients in accordance with previous studies; previously reported elevated risks for other digestive tract cancers were not confirmed. There was a non-significantly increased risk for lymphatic and haematological malignancy but the risk tended to disappear after 5 years of follow-up, indicating a possible selection bias. Decreased risks for cervical cancer and non-melanoma skin cancer were also seen. SN - 0007-0920 UR - https://www.unboundmedicine.com/medline/citation/8611439/Pernicious_anaemia_and_cancer_risk_in_Denmark_ L2 - https://www.ncbi.nlm.nih.gov/pmc/articles/pmid/8611439/ DB - PRIME DP - Unbound Medicine ER -