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Pernicious anaemia and cancer risk in Denmark.

Abstract

A cohort of 5072 patients with pernicious anaemia was identified in the Danish Hospital Discharge Register from 1977 to 1989 and, through linkage to the Danish Cancer Registry, the occurrence of cancer in the cohort was determined up to 1991. Observed numbers of cancer cases during 1-15 years of follow-up were compared with expected numbers based on national incidence rates. Besides the well-established increased risk for stomach cancer, the analysis also revealed a 2-fold increase in the relative risk for cancer of the buccal cavity and pharynx among pernicious anaemia patients in accordance with previous studies; previously reported elevated risks for other digestive tract cancers were not confirmed. There was a non-significantly increased risk for lymphatic and haematological malignancy but the risk tended to disappear after 5 years of follow-up, indicating a possible selection bias. Decreased risks for cervical cancer and non-melanoma skin cancer were also seen.

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  • Authors+Show Affiliations

    ,

    Danish Cancer Society, Division for Cancer Epidemiology, Copenhagen O, Denmark.

    , , , , ,

    Source

    British journal of cancer 73:8 1996 Apr pg 998-1000

    MeSH

    Aged
    Anemia, Pernicious
    Cohort Studies
    Female
    Humans
    Male
    Neoplasms
    Risk

    Pub Type(s)

    Journal Article
    Research Support, Non-U.S. Gov't
    Research Support, U.S. Gov't, P.H.S.

    Language

    eng

    PubMed ID

    8611439

    Citation

    Mellemkjaer, L, et al. "Pernicious Anaemia and Cancer Risk in Denmark." British Journal of Cancer, vol. 73, no. 8, 1996, pp. 998-1000.
    Mellemkjaer L, Gridley G, Møller H, et al. Pernicious anaemia and cancer risk in Denmark. Br J Cancer. 1996;73(8):998-1000.
    Mellemkjaer, L., Gridley, G., Møller, H., Hsing, A. W., Linet, M. S., Brinton, L. A., & Olsen, J. H. (1996). Pernicious anaemia and cancer risk in Denmark. British Journal of Cancer, 73(8), pp. 998-1000.
    Mellemkjaer L, et al. Pernicious Anaemia and Cancer Risk in Denmark. Br J Cancer. 1996;73(8):998-1000. PubMed PMID: 8611439.
    * Article titles in AMA citation format should be in sentence-case
    TY - JOUR T1 - Pernicious anaemia and cancer risk in Denmark. AU - Mellemkjaer,L, AU - Gridley,G, AU - Møller,H, AU - Hsing,A W, AU - Linet,M S, AU - Brinton,L A, AU - Olsen,J H, PY - 1996/4/1/pubmed PY - 1996/4/1/medline PY - 1996/4/1/entrez SP - 998 EP - 1000 JF - British journal of cancer JO - Br. J. Cancer VL - 73 IS - 8 N2 - A cohort of 5072 patients with pernicious anaemia was identified in the Danish Hospital Discharge Register from 1977 to 1989 and, through linkage to the Danish Cancer Registry, the occurrence of cancer in the cohort was determined up to 1991. Observed numbers of cancer cases during 1-15 years of follow-up were compared with expected numbers based on national incidence rates. Besides the well-established increased risk for stomach cancer, the analysis also revealed a 2-fold increase in the relative risk for cancer of the buccal cavity and pharynx among pernicious anaemia patients in accordance with previous studies; previously reported elevated risks for other digestive tract cancers were not confirmed. There was a non-significantly increased risk for lymphatic and haematological malignancy but the risk tended to disappear after 5 years of follow-up, indicating a possible selection bias. Decreased risks for cervical cancer and non-melanoma skin cancer were also seen. SN - 0007-0920 UR - https://www.unboundmedicine.com/medline/citation/8611439/Pernicious_anaemia_and_cancer_risk_in_Denmark_ L2 - https://www.ncbi.nlm.nih.gov/pmc/articles/pmid/8611439/ DB - PRIME DP - Unbound Medicine ER -