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How much lactose is low lactose?
J Am Diet Assoc. 1996 Mar; 96(3):243-6.JA

Abstract

OBJECTIVE

To test the hypothesis that complete elimination of lactose is not necessary to ensure tolerance by lactose maldigesters.

DESIGN

Double-blind, randomized protocol in which challenge doses of 0, 2, 6, 12, and 20 g lactose in water were fed to subjects after a 12-hour fast.

SUBJECTS

13 healthy, free-living adults who were lactose maldigesters.

MAIN OUTCOME MEASURES

Breath hydrogen production (a measure of maldigestion) and symptom response to each challenge dose.

STATISTICAL ANALYSIS

Analysis of variance was done to determine overall differences in mean hydrogen gas production (peak and sum of hours 1 through 8). Friedman's test was used to determine overall differences in the mean ranks for each symptom. Fisher's least significant difference test was used for multiple comparisons for hydrogen and symptom and data.

RESULTS

Hydrogen production after consumption of the 0- and 2-g lactose doses was not significantly different. Hydrogen production increased with the 6-g dose. Intensity of abdominal pain increased when the dose of lactose was 12 g. Episodes of flatulence did not increase until the dose reached 20 g. No significant differences in the occurrence of diarrhea were observed after the five treatments.

CONCLUSIONS

No significant increase in breath hydrogen production or intolerance symptoms occurred after consumption of a 2-g dose of lactose. Up to 6 g was tolerated, even though maldigestion could be measured at the 6-g dose. Thus, lactose maldigesters may be able to tolerate foods containing 6 g lactose or less per serving, such as hard cheeses and small servings (120 mL or less) of milk.

Authors+Show Affiliations

Department of Food Science and Nutrition, University of Minnesota, St. Paul, USA.No affiliation info availableNo affiliation info available

Pub Type(s)

Clinical Trial
Journal Article
Randomized Controlled Trial
Research Support, Non-U.S. Gov't

Language

eng

PubMed ID

8613657

Citation

Hertzler, S R., et al. "How Much Lactose Is Low Lactose?" Journal of the American Dietetic Association, vol. 96, no. 3, 1996, pp. 243-6.
Hertzler SR, Huynh BC, Savaiano DA. How much lactose is low lactose? J Am Diet Assoc. 1996;96(3):243-6.
Hertzler, S. R., Huynh, B. C., & Savaiano, D. A. (1996). How much lactose is low lactose? Journal of the American Dietetic Association, 96(3), 243-6.
Hertzler SR, Huynh BC, Savaiano DA. How Much Lactose Is Low Lactose. J Am Diet Assoc. 1996;96(3):243-6. PubMed PMID: 8613657.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - How much lactose is low lactose? AU - Hertzler,S R, AU - Huynh,B C, AU - Savaiano,D A, PY - 1996/3/1/pubmed PY - 1996/3/1/medline PY - 1996/3/1/entrez SP - 243 EP - 6 JF - Journal of the American Dietetic Association JO - J Am Diet Assoc VL - 96 IS - 3 N2 - OBJECTIVE: To test the hypothesis that complete elimination of lactose is not necessary to ensure tolerance by lactose maldigesters. DESIGN: Double-blind, randomized protocol in which challenge doses of 0, 2, 6, 12, and 20 g lactose in water were fed to subjects after a 12-hour fast. SUBJECTS: 13 healthy, free-living adults who were lactose maldigesters. MAIN OUTCOME MEASURES: Breath hydrogen production (a measure of maldigestion) and symptom response to each challenge dose. STATISTICAL ANALYSIS: Analysis of variance was done to determine overall differences in mean hydrogen gas production (peak and sum of hours 1 through 8). Friedman's test was used to determine overall differences in the mean ranks for each symptom. Fisher's least significant difference test was used for multiple comparisons for hydrogen and symptom and data. RESULTS: Hydrogen production after consumption of the 0- and 2-g lactose doses was not significantly different. Hydrogen production increased with the 6-g dose. Intensity of abdominal pain increased when the dose of lactose was 12 g. Episodes of flatulence did not increase until the dose reached 20 g. No significant differences in the occurrence of diarrhea were observed after the five treatments. CONCLUSIONS: No significant increase in breath hydrogen production or intolerance symptoms occurred after consumption of a 2-g dose of lactose. Up to 6 g was tolerated, even though maldigestion could be measured at the 6-g dose. Thus, lactose maldigesters may be able to tolerate foods containing 6 g lactose or less per serving, such as hard cheeses and small servings (120 mL or less) of milk. SN - 0002-8223 UR - https://www.unboundmedicine.com/medline/citation/8613657/How_much_lactose_is_low_lactose L2 - https://linkinghub.elsevier.com/retrieve/pii/S0002-8223(96)00074-0 DB - PRIME DP - Unbound Medicine ER -