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Diet and risk of non-Hodgkin lymphoma in older women.
JAMA 1996; 275(17):1315-21JAMA

Abstract

OBJECTIVE

To test whether high dietary intakes of fat, protein, and milk are associated with the development of non-Hodgkin lymphoma in older women.

DESIGN

Prospective cohort study with a 7-year follow-up period.

SETTING

General community.

PARTICIPANTS

Sample of 35 156 Iowa women aged 55 to 69 years with no prior history of cancer who returned the 1986 baseline questionnaire.

MAIN OUTCOME MEASURE

Non-Hodgkin lymphoma (104 incident cases).

MAIN RESULTS

After controlling for age, marital status, residence, total energy intake, and transfusion history, the relative risks (RRs) for the highest tertile of intake compared with the lowest were 2.00 (95% confidence interval [CI], 1.21-3.30; P for trend = .01) for animal fat, 1.69 (95% CI, 1.07-2.67; P for trend = .02) for saturated fat, and 1.90 (95% CI, 1.18-3.04; P for trend = .01) for monounsaturated fat, and there was no association with vegetable fat or polyunsaturated fat. Greater intake of animal protein (RR = 1.52; 95% CI, 0.94-2.44; P for trend = .08), but not vegetable protein, was associated with elevated risk, and this was mainly explained by greater consumption of red meat (RR = 1.98; 95% CI, 1.13-3.47; P for trend = .02) and hamburger in particular (RR = 2.35; 95% CI, 1.23-4.48; P for trend = .02). Milk and dairy product consumption were not associated with elevated risk. There was also a decreased risk of non-Hodgkin lymphoma with greater consumption of fruits (RR = 0.64; 95% CI, 0.40-1.05; P for trend = .07).

CONCLUSIONS

A high-meat diet and a high intake of fat from animal sources is associated with an increased risk of non-Hodgkin lymphoma in older women.

Authors+Show Affiliations

Department of Preventive Medicine and Environmental Health, College of Medicine, University of Iowa, Iowa City, USA.No affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Journal Article
Research Support, U.S. Gov't, P.H.S.

Language

eng

PubMed ID

8614116

Citation

Chiu, B C., et al. "Diet and Risk of non-Hodgkin Lymphoma in Older Women." JAMA, vol. 275, no. 17, 1996, pp. 1315-21.
Chiu BC, Cerhan JR, Folsom AR, et al. Diet and risk of non-Hodgkin lymphoma in older women. JAMA. 1996;275(17):1315-21.
Chiu, B. C., Cerhan, J. R., Folsom, A. R., Sellers, T. A., Kushi, L. H., Wallace, R. B., ... Potter, J. D. (1996). Diet and risk of non-Hodgkin lymphoma in older women. JAMA, 275(17), pp. 1315-21.
Chiu BC, et al. Diet and Risk of non-Hodgkin Lymphoma in Older Women. JAMA. 1996 May 1;275(17):1315-21. PubMed PMID: 8614116.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Diet and risk of non-Hodgkin lymphoma in older women. AU - Chiu,B C, AU - Cerhan,J R, AU - Folsom,A R, AU - Sellers,T A, AU - Kushi,L H, AU - Wallace,R B, AU - Zheng,W, AU - Potter,J D, PY - 1996/5/1/pubmed PY - 1996/5/1/medline PY - 1996/5/1/entrez SP - 1315 EP - 21 JF - JAMA JO - JAMA VL - 275 IS - 17 N2 - OBJECTIVE: To test whether high dietary intakes of fat, protein, and milk are associated with the development of non-Hodgkin lymphoma in older women. DESIGN: Prospective cohort study with a 7-year follow-up period. SETTING: General community. PARTICIPANTS: Sample of 35 156 Iowa women aged 55 to 69 years with no prior history of cancer who returned the 1986 baseline questionnaire. MAIN OUTCOME MEASURE: Non-Hodgkin lymphoma (104 incident cases). MAIN RESULTS: After controlling for age, marital status, residence, total energy intake, and transfusion history, the relative risks (RRs) for the highest tertile of intake compared with the lowest were 2.00 (95% confidence interval [CI], 1.21-3.30; P for trend = .01) for animal fat, 1.69 (95% CI, 1.07-2.67; P for trend = .02) for saturated fat, and 1.90 (95% CI, 1.18-3.04; P for trend = .01) for monounsaturated fat, and there was no association with vegetable fat or polyunsaturated fat. Greater intake of animal protein (RR = 1.52; 95% CI, 0.94-2.44; P for trend = .08), but not vegetable protein, was associated with elevated risk, and this was mainly explained by greater consumption of red meat (RR = 1.98; 95% CI, 1.13-3.47; P for trend = .02) and hamburger in particular (RR = 2.35; 95% CI, 1.23-4.48; P for trend = .02). Milk and dairy product consumption were not associated with elevated risk. There was also a decreased risk of non-Hodgkin lymphoma with greater consumption of fruits (RR = 0.64; 95% CI, 0.40-1.05; P for trend = .07). CONCLUSIONS: A high-meat diet and a high intake of fat from animal sources is associated with an increased risk of non-Hodgkin lymphoma in older women. SN - 0098-7484 UR - https://www.unboundmedicine.com/medline/citation/8614116/Diet_and_risk_of_non_Hodgkin_lymphoma_in_older_women_ L2 - https://jamanetwork.com/journals/jama/fullarticle/vol/275/pg/1315 DB - PRIME DP - Unbound Medicine ER -