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Epidemiologic analysis of Crohn disease in Japan: increased dietary intake of n-6 polyunsaturated fatty acids and animal protein relates to the increased incidence of Crohn disease in Japan.

Abstract

We examined the correlation between the incidence of Crohn disease and dietary change in a relatively homogeneous Japanese population. The incidence and daily intake of each dietary component were compared annually from 1966 to 1985. The univariate analysis showed that the increased incidence of Crohn disease was strongly (P < 0.001) correlated with increased dietary intake of total fat (r = 0.919). animal fat (r = 0.880), n-6 polyunsaturated fatty acids (r = 0.883), animal protein (r = 0.908), milk protein (r = 0.924), and the ratio of n-6 to n-3 fatty acid intake (r = 0.792). It was less correlated with intake of total protein (r = 0.482, P < 0.05), was not correlated with intake of fish protein (r = 0.055, P > 0.1), and was inversely correlated with intake of vegetable protein (r = -0.941, P < 0.001). The multivariate analysis showed that increased intake of animal protein was the strongest independent factor with a weaker second factor, an increased ration of n-6 to n-3 polyunsaturated fatty acids. The present study in association with reported clinical studies suggests that increased dietary intake of animal protein and n-6 polyunsaturated fatty acids with less n-3 polyunsaturated fatty acids may contribute to the development of Crohn disease.

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  • Authors+Show Affiliations

    ,

    Division of Gastroenterology, International Medical Center of Japan, Tokyo.

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    MeSH

    Adult
    Crohn Disease
    Diet
    Dietary Fats
    Dietary Proteins
    Fatty Acids, Omega-6
    Fatty Acids, Unsaturated
    Female
    Humans
    Incidence
    Japan
    Male
    Multivariate Analysis

    Pub Type(s)

    Journal Article

    Language

    eng

    PubMed ID

    8615358

    Citation

    Shoda, R, et al. "Epidemiologic Analysis of Crohn Disease in Japan: Increased Dietary Intake of N-6 Polyunsaturated Fatty Acids and Animal Protein Relates to the Increased Incidence of Crohn Disease in Japan." The American Journal of Clinical Nutrition, vol. 63, no. 5, 1996, pp. 741-5.
    Shoda R, Matsueda K, Yamato S, et al. Epidemiologic analysis of Crohn disease in Japan: increased dietary intake of n-6 polyunsaturated fatty acids and animal protein relates to the increased incidence of Crohn disease in Japan. Am J Clin Nutr. 1996;63(5):741-5.
    Shoda, R., Matsueda, K., Yamato, S., & Umeda, N. (1996). Epidemiologic analysis of Crohn disease in Japan: increased dietary intake of n-6 polyunsaturated fatty acids and animal protein relates to the increased incidence of Crohn disease in Japan. The American Journal of Clinical Nutrition, 63(5), pp. 741-5.
    Shoda R, et al. Epidemiologic Analysis of Crohn Disease in Japan: Increased Dietary Intake of N-6 Polyunsaturated Fatty Acids and Animal Protein Relates to the Increased Incidence of Crohn Disease in Japan. Am J Clin Nutr. 1996;63(5):741-5. PubMed PMID: 8615358.
    * Article titles in AMA citation format should be in sentence-case
    TY - JOUR T1 - Epidemiologic analysis of Crohn disease in Japan: increased dietary intake of n-6 polyunsaturated fatty acids and animal protein relates to the increased incidence of Crohn disease in Japan. AU - Shoda,R, AU - Matsueda,K, AU - Yamato,S, AU - Umeda,N, PY - 1996/5/1/pubmed PY - 1996/5/1/medline PY - 1996/5/1/entrez SP - 741 EP - 5 JF - The American journal of clinical nutrition JO - Am. J. Clin. Nutr. VL - 63 IS - 5 N2 - We examined the correlation between the incidence of Crohn disease and dietary change in a relatively homogeneous Japanese population. The incidence and daily intake of each dietary component were compared annually from 1966 to 1985. The univariate analysis showed that the increased incidence of Crohn disease was strongly (P < 0.001) correlated with increased dietary intake of total fat (r = 0.919). animal fat (r = 0.880), n-6 polyunsaturated fatty acids (r = 0.883), animal protein (r = 0.908), milk protein (r = 0.924), and the ratio of n-6 to n-3 fatty acid intake (r = 0.792). It was less correlated with intake of total protein (r = 0.482, P < 0.05), was not correlated with intake of fish protein (r = 0.055, P > 0.1), and was inversely correlated with intake of vegetable protein (r = -0.941, P < 0.001). The multivariate analysis showed that increased intake of animal protein was the strongest independent factor with a weaker second factor, an increased ration of n-6 to n-3 polyunsaturated fatty acids. The present study in association with reported clinical studies suggests that increased dietary intake of animal protein and n-6 polyunsaturated fatty acids with less n-3 polyunsaturated fatty acids may contribute to the development of Crohn disease. SN - 0002-9165 UR - https://www.unboundmedicine.com/medline/citation/8615358/full_citation L2 - https://academic.oup.com/ajcn/article-lookup/doi/10.1093/ajcn/63.5.741 DB - PRIME DP - Unbound Medicine ER -