Abstract
OBJECTIVES
To assess the relative contribution of genetic and environmental factors to common forms of osteoarthritis of the hands and knees.
DESIGN
Classic twin study with unselected twins who were screened radiologically for osteoarthritis.
SUBJECTS
130 identical and 120 non-identical female twins aged 48-70 recruited from a London based twin register and through a national media campaign.
MAIN OUTCOME MEASURES
Similarity in identical compared with non-identical twin pairs for radiographic changes at the interphalangeal and first carpometacarpal joints of the hands and the tibiofemoral joint and patellofemoral joint of the knee expressed as intraclass correlations.
RESULTS
The intraclass correlations of radiographic osteophytes and narrowing at most sites and the presence of Heberden's nodes and knee pain were higher in the identical pairs. The intraclass correlation of the total radiographic osteoarthritis score in identical pairs (rMZ) was 0.64 (SE 0.05) compared with 0.38 (0.08) in non-identical pairs. The proportion of genetic variance of total osteoarthritis score (osteophytes and narrowing) with modelling techniques was estimated at 0.54 (95% confidence interval 0.43 to 0.65) and ranged from 0.39 to 0.65 for different sites and features (p < 0.001) after adjustment for age and weight.
CONCLUSIONS
These results demonstrate for the first time a clear genetic effect for radiographic osteoarthritis of the hand and knee in women, with a genetic influence ranging from 39-65%, independent of known environmental or demographic confounders. The results of this study should lead to further work on isolating the gene or genes involved in the pathogenesis of the common disabling disease.
TY - JOUR
T1 - Genetic influences on osteoarthritis in women: a twin study.
AU - Spector,T D,
AU - Cicuttini,F,
AU - Baker,J,
AU - Loughlin,J,
AU - Hart,D,
PY - 1996/4/13/pubmed
PY - 1996/4/13/medline
PY - 1996/4/13/entrez
SP - 940
EP - 3
JF - BMJ (Clinical research ed.)
JO - BMJ
VL - 312
IS - 7036
N2 - OBJECTIVES: To assess the relative contribution of genetic and environmental factors to common forms of osteoarthritis of the hands and knees. DESIGN: Classic twin study with unselected twins who were screened radiologically for osteoarthritis. SUBJECTS: 130 identical and 120 non-identical female twins aged 48-70 recruited from a London based twin register and through a national media campaign. MAIN OUTCOME MEASURES: Similarity in identical compared with non-identical twin pairs for radiographic changes at the interphalangeal and first carpometacarpal joints of the hands and the tibiofemoral joint and patellofemoral joint of the knee expressed as intraclass correlations. RESULTS: The intraclass correlations of radiographic osteophytes and narrowing at most sites and the presence of Heberden's nodes and knee pain were higher in the identical pairs. The intraclass correlation of the total radiographic osteoarthritis score in identical pairs (rMZ) was 0.64 (SE 0.05) compared with 0.38 (0.08) in non-identical pairs. The proportion of genetic variance of total osteoarthritis score (osteophytes and narrowing) with modelling techniques was estimated at 0.54 (95% confidence interval 0.43 to 0.65) and ranged from 0.39 to 0.65 for different sites and features (p < 0.001) after adjustment for age and weight. CONCLUSIONS: These results demonstrate for the first time a clear genetic effect for radiographic osteoarthritis of the hand and knee in women, with a genetic influence ranging from 39-65%, independent of known environmental or demographic confounders. The results of this study should lead to further work on isolating the gene or genes involved in the pathogenesis of the common disabling disease.
SN - 0959-8138
UR - https://www.unboundmedicine.com/medline/citation/8616305/Genetic_influences_on_osteoarthritis_in_women:_a_twin_study_
L2 - https://www.bmj.com/lookup/pmidlookup?view=long&pmid=8616305
DB - PRIME
DP - Unbound Medicine
ER -
