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Male pseudohermaphroditism: diagnosis in cell culture.
Can Med Assoc J. 1977 Jun 04; 116(11):1274-5, 1277.CM

Abstract

Testicular feminization is a classic form of complete male pseudohermaphroditism. The individuals have a normal XY karyotype but unambiguously female external genitalia. They have congenital complete insensitivity to androgen due to an X-linked mutation. In four patients (from tow families with several affected members) with the typical phenotype of testicular feminization, a severe deficit of specific androgen-binding activity was detected in cultured fibroblasts from labium majus skin. Measurement of this activity in genital skin fibroblasts improves the differential diagnosis in patients with complete or imcomplete male pseudohermaphroditism before puberty.

Authors

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Pub Type(s)

Journal Article

Language

eng

PubMed ID

861885

Citation

Pinsky, L, et al. "Male Pseudohermaphroditism: Diagnosis in Cell Culture." Canadian Medical Association Journal, vol. 116, no. 11, 1977, pp. 1274-5, 1277.
Pinsky L, Kaufman M, Lambert B, et al. Male pseudohermaphroditism: diagnosis in cell culture. Can Med Assoc J. 1977;116(11):1274-5, 1277.
Pinsky, L., Kaufman, M., Lambert, B., Faucher, G., & Rosenfeld, R. (1977). Male pseudohermaphroditism: diagnosis in cell culture. Canadian Medical Association Journal, 116(11), 1274-5, 1277.
Pinsky L, et al. Male Pseudohermaphroditism: Diagnosis in Cell Culture. Can Med Assoc J. 1977 Jun 4;116(11):1274-5, 1277. PubMed PMID: 861885.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Male pseudohermaphroditism: diagnosis in cell culture. AU - Pinsky,L, AU - Kaufman,M, AU - Lambert,B, AU - Faucher,G, AU - Rosenfeld,R, PY - 1977/6/4/pubmed PY - 1977/6/4/medline PY - 1977/6/4/entrez SP - 1274-5, 1277 JF - Canadian Medical Association journal JO - Can Med Assoc J VL - 116 IS - 11 N2 - Testicular feminization is a classic form of complete male pseudohermaphroditism. The individuals have a normal XY karyotype but unambiguously female external genitalia. They have congenital complete insensitivity to androgen due to an X-linked mutation. In four patients (from tow families with several affected members) with the typical phenotype of testicular feminization, a severe deficit of specific androgen-binding activity was detected in cultured fibroblasts from labium majus skin. Measurement of this activity in genital skin fibroblasts improves the differential diagnosis in patients with complete or imcomplete male pseudohermaphroditism before puberty. SN - 0008-4409 UR - https://www.unboundmedicine.com/medline/citation/861885/Male_pseudohermaphroditism:_diagnosis_in_cell_culture_ L2 - https://www.ncbi.nlm.nih.gov/pmc/articles/pmid/861885/ DB - PRIME DP - Unbound Medicine ER -