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Soft tissue body composition: familial resemblance and independent influences on bone mineral density.
J Bone Miner Res. 1995 Dec; 10(12):1944-50.JB

Abstract

Familial resemblance in fat and lean soft tissue and the influence of these body composition measures on bone mineral density (BMD) were determined in 162 adult members of 42 families. Whole body fat and lean mass and BMD of the spine and femoral neck were measured by dual-energy X-ray absorptiometry and BMD of the heel and radius by single-photon absorptiometry. Significant correlations of lean tissue were observed between mothers and daughters (r = 0.35, p < 0.05), fathers and sons (r = 0.36, p < 0.05), and daughters and sons (r - 0.42, p < 0.01) after adjustment for age, height, fat mass, physical activity, and parity (among women). Fat tissue was not significantly correlated among any family member pairs. Lean tissue, but not fat, was positively associated with BMD in one or more family member subgroups at all skeletal sites. These findings suggest a hereditary component to muscle mass. Previously documented familial similarities in bone density may be related in part to the influence of lean mass on bone density.

Authors+Show Affiliations

Jean Mayer USDA Human Nutrition Research Center of Aging, Tufts University, Boston, Massachusetts, USA.No affiliation info available

Pub Type(s)

Journal Article
Research Support, Non-U.S. Gov't
Research Support, U.S. Gov't, Non-P.H.S.

Language

eng

PubMed ID

8619375

Citation

Krall, E A., and B Dawson-Hughes. "Soft Tissue Body Composition: Familial Resemblance and Independent Influences On Bone Mineral Density." Journal of Bone and Mineral Research : the Official Journal of the American Society for Bone and Mineral Research, vol. 10, no. 12, 1995, pp. 1944-50.
Krall EA, Dawson-Hughes B. Soft tissue body composition: familial resemblance and independent influences on bone mineral density. J Bone Miner Res. 1995;10(12):1944-50.
Krall, E. A., & Dawson-Hughes, B. (1995). Soft tissue body composition: familial resemblance and independent influences on bone mineral density. Journal of Bone and Mineral Research : the Official Journal of the American Society for Bone and Mineral Research, 10(12), 1944-50.
Krall EA, Dawson-Hughes B. Soft Tissue Body Composition: Familial Resemblance and Independent Influences On Bone Mineral Density. J Bone Miner Res. 1995;10(12):1944-50. PubMed PMID: 8619375.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Soft tissue body composition: familial resemblance and independent influences on bone mineral density. AU - Krall,E A, AU - Dawson-Hughes,B, PY - 1995/12/1/pubmed PY - 1995/12/1/medline PY - 1995/12/1/entrez SP - 1944 EP - 50 JF - Journal of bone and mineral research : the official journal of the American Society for Bone and Mineral Research JO - J. Bone Miner. Res. VL - 10 IS - 12 N2 - Familial resemblance in fat and lean soft tissue and the influence of these body composition measures on bone mineral density (BMD) were determined in 162 adult members of 42 families. Whole body fat and lean mass and BMD of the spine and femoral neck were measured by dual-energy X-ray absorptiometry and BMD of the heel and radius by single-photon absorptiometry. Significant correlations of lean tissue were observed between mothers and daughters (r = 0.35, p < 0.05), fathers and sons (r = 0.36, p < 0.05), and daughters and sons (r - 0.42, p < 0.01) after adjustment for age, height, fat mass, physical activity, and parity (among women). Fat tissue was not significantly correlated among any family member pairs. Lean tissue, but not fat, was positively associated with BMD in one or more family member subgroups at all skeletal sites. These findings suggest a hereditary component to muscle mass. Previously documented familial similarities in bone density may be related in part to the influence of lean mass on bone density. SN - 0884-0431 UR - https://www.unboundmedicine.com/medline/citation/8619375/Soft_tissue_body_composition:_familial_resemblance_and_independent_influences_on_bone_mineral_density_ L2 - https://doi.org/10.1002/jbmr.5650101214 DB - PRIME DP - Unbound Medicine ER -