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Anti-GD1a ganglioside antibodies in peripheral motor syndromes.
Ann Neurol. 1996 Apr; 39(4):539-43.AN

Abstract

High titers of anti-GD1a antibodies have been found in patients with Guillain-Barre syndrome or motor neuropathy. To determine the possible diagnostic relevance of these antibodies, we measured serum anti-GD1a IgG and IgM antibodies by enzyme-linked immunosorbent assay in 195 patients with different motor syndromes and in 335 control subjects. Moderately high antibody titers (1/1,280-1/5,120) were occasionally found in patients with chronic inflammatory demyelinating polyneuropathy (5%), multifocal motor neuropathy (18%), lower motor neuron disease (3.8%), or amyotrophic lateral sclerosis (1.8%) and in immunological control subjects (1.2%), while titers of 1/20,480 or higher were only found in 2 patients with Guillain-Barre syndrome (IgG in both) and 2 with motor neuropathy and IgM lambda monoclonal gammopathy improving with immunotherapy. In both motor neuropathy patients and the Guillain-Barre syndrome patient who were retested during recovery, anti-GD1a titers decreased concomitantly with clinical improvement. High anti-GD1a antibody titers may be found in several motor syndromes but only markedly increased anti-GD1a titers are strictly associated with potentially treatable dysimmune neuropathies.

Authors+Show Affiliations

Institute of Clinical Neurology, Centro Dino Ferrari, Ospedale Maggiore Policlinico, University of Milan, Italy.No affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Case Reports
Journal Article
Research Support, Non-U.S. Gov't

Language

eng

PubMed ID

8619533

Citation

Carpo, M, et al. "Anti-GD1a Ganglioside Antibodies in Peripheral Motor Syndromes." Annals of Neurology, vol. 39, no. 4, 1996, pp. 539-43.
Carpo M, Nobile-Orazio E, Meucci N, et al. Anti-GD1a ganglioside antibodies in peripheral motor syndromes. Ann Neurol. 1996;39(4):539-43.
Carpo, M., Nobile-Orazio, E., Meucci, N., Gamba, M., Barbieri, S., Allaria, S., & Scarlato, G. (1996). Anti-GD1a ganglioside antibodies in peripheral motor syndromes. Annals of Neurology, 39(4), 539-43.
Carpo M, et al. Anti-GD1a Ganglioside Antibodies in Peripheral Motor Syndromes. Ann Neurol. 1996;39(4):539-43. PubMed PMID: 8619533.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Anti-GD1a ganglioside antibodies in peripheral motor syndromes. AU - Carpo,M, AU - Nobile-Orazio,E, AU - Meucci,N, AU - Gamba,M, AU - Barbieri,S, AU - Allaria,S, AU - Scarlato,G, PY - 1996/4/1/pubmed PY - 1996/4/1/medline PY - 1996/4/1/entrez SP - 539 EP - 43 JF - Annals of neurology JO - Ann Neurol VL - 39 IS - 4 N2 - High titers of anti-GD1a antibodies have been found in patients with Guillain-Barre syndrome or motor neuropathy. To determine the possible diagnostic relevance of these antibodies, we measured serum anti-GD1a IgG and IgM antibodies by enzyme-linked immunosorbent assay in 195 patients with different motor syndromes and in 335 control subjects. Moderately high antibody titers (1/1,280-1/5,120) were occasionally found in patients with chronic inflammatory demyelinating polyneuropathy (5%), multifocal motor neuropathy (18%), lower motor neuron disease (3.8%), or amyotrophic lateral sclerosis (1.8%) and in immunological control subjects (1.2%), while titers of 1/20,480 or higher were only found in 2 patients with Guillain-Barre syndrome (IgG in both) and 2 with motor neuropathy and IgM lambda monoclonal gammopathy improving with immunotherapy. In both motor neuropathy patients and the Guillain-Barre syndrome patient who were retested during recovery, anti-GD1a titers decreased concomitantly with clinical improvement. High anti-GD1a antibody titers may be found in several motor syndromes but only markedly increased anti-GD1a titers are strictly associated with potentially treatable dysimmune neuropathies. SN - 0364-5134 UR - https://www.unboundmedicine.com/medline/citation/8619533/Anti_GD1a_ganglioside_antibodies_in_peripheral_motor_syndromes_ L2 - https://onlinelibrary.wiley.com/resolve/openurl?genre=article&sid=nlm:pubmed&issn=0364-5134&date=1996&volume=39&issue=4&spage=539 DB - PRIME DP - Unbound Medicine ER -