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Effects of colestipol alone and in combination with simvastatin on apolipoprotein B metabolism.
Arterioscler Thromb Vasc Biol. 1996 Feb; 16(2):236-49.AT

Abstract

The effects of colestipol therapy alone (20 g/d) or combined with simvastatin (20 mg/d) were examined in a group of eight male patients with primary moderate hypercholesterolemia (total cholesterol > or = 6.5 mmol/L [> or = 250 mg/dL]) who had undergone coronary artery bypass grafting more than 3 months previously. Colestipol therapy decreased total cholesterol by 14% (P < .001) and LDL cholesterol (LDL-C) by 23% (P < .001), while dual therapy decreased total cholesterol by 38% and LDL-C by 52% (both P < .001 versus baseline). No significant changes were observed in plasma triglyceride, VLDL cholesterol, or HDL cholesterol levels. VLDL subfraction turnovers were conducted at baseline and again on each regimen. ApoB kinetic parameters derived from a multicompartmental model suggested that colestipol therapy resulted in an expansion of the total VLDL apoB pool (36%, P < .05) that was largely due to a fall in the clearance rate of VLDL1 apoB (49%), while the LDL apoB pool decreased 23% as a result of diminished direct LDL input. The model used also revealed that addition of simvastatin to the resin therapy caused increases in the fractional transfer rates of VLDL2 to IDL and IDL to LDL together with a 37% increment in the LDL apoB fractional catabolic rate. Compared with baseline, combined therapy generated falls in both IDL (35%, P = .01) and LDL (37%, P < .04) apoB pools due to enhanced clearance of IDL (214%, P < .03) and reduced total input of LDL (39%, P < .003).

Authors+Show Affiliations

Institute of Biochemistry, Glasgow Royal Infirmary, UK.No affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Clinical Trial
Controlled Clinical Trial
Journal Article
Research Support, Non-U.S. Gov't

Language

eng

PubMed ID

8620338

Citation

Gaw, A, et al. "Effects of Colestipol Alone and in Combination With Simvastatin On Apolipoprotein B Metabolism." Arteriosclerosis, Thrombosis, and Vascular Biology, vol. 16, no. 2, 1996, pp. 236-49.
Gaw A, Packard CJ, Lindsay GM, et al. Effects of colestipol alone and in combination with simvastatin on apolipoprotein B metabolism. Arterioscler Thromb Vasc Biol. 1996;16(2):236-49.
Gaw, A., Packard, C. J., Lindsay, G. M., Murray, E. F., Griffin, B. A., Caslake, M. J., Colquhoun, I., Wheatley, D. J., Lorimer, A. R., & Shepherd, J. (1996). Effects of colestipol alone and in combination with simvastatin on apolipoprotein B metabolism. Arteriosclerosis, Thrombosis, and Vascular Biology, 16(2), 236-49.
Gaw A, et al. Effects of Colestipol Alone and in Combination With Simvastatin On Apolipoprotein B Metabolism. Arterioscler Thromb Vasc Biol. 1996;16(2):236-49. PubMed PMID: 8620338.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Effects of colestipol alone and in combination with simvastatin on apolipoprotein B metabolism. AU - Gaw,A, AU - Packard,C J, AU - Lindsay,G M, AU - Murray,E F, AU - Griffin,B A, AU - Caslake,M J, AU - Colquhoun,I, AU - Wheatley,D J, AU - Lorimer,A R, AU - Shepherd,J, PY - 1996/2/1/pubmed PY - 1996/2/1/medline PY - 1996/2/1/entrez SP - 236 EP - 49 JF - Arteriosclerosis, thrombosis, and vascular biology JO - Arterioscler Thromb Vasc Biol VL - 16 IS - 2 N2 - The effects of colestipol therapy alone (20 g/d) or combined with simvastatin (20 mg/d) were examined in a group of eight male patients with primary moderate hypercholesterolemia (total cholesterol > or = 6.5 mmol/L [> or = 250 mg/dL]) who had undergone coronary artery bypass grafting more than 3 months previously. Colestipol therapy decreased total cholesterol by 14% (P < .001) and LDL cholesterol (LDL-C) by 23% (P < .001), while dual therapy decreased total cholesterol by 38% and LDL-C by 52% (both P < .001 versus baseline). No significant changes were observed in plasma triglyceride, VLDL cholesterol, or HDL cholesterol levels. VLDL subfraction turnovers were conducted at baseline and again on each regimen. ApoB kinetic parameters derived from a multicompartmental model suggested that colestipol therapy resulted in an expansion of the total VLDL apoB pool (36%, P < .05) that was largely due to a fall in the clearance rate of VLDL1 apoB (49%), while the LDL apoB pool decreased 23% as a result of diminished direct LDL input. The model used also revealed that addition of simvastatin to the resin therapy caused increases in the fractional transfer rates of VLDL2 to IDL and IDL to LDL together with a 37% increment in the LDL apoB fractional catabolic rate. Compared with baseline, combined therapy generated falls in both IDL (35%, P = .01) and LDL (37%, P < .04) apoB pools due to enhanced clearance of IDL (214%, P < .03) and reduced total input of LDL (39%, P < .003). SN - 1079-5642 UR - https://www.unboundmedicine.com/medline/citation/8620338/Effects_of_colestipol_alone_and_in_combination_with_simvastatin_on_apolipoprotein_B_metabolism_ L2 - https://www.ahajournals.org/doi/10.1161/01.atv.16.2.236?url_ver=Z39.88-2003&amp;rfr_id=ori:rid:crossref.org&amp;rfr_dat=cr_pub=pubmed DB - PRIME DP - Unbound Medicine ER -