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Respiratory-mucosal lymphocyte populations induced by reovirus serotype 1 infection.
Cell Immunol. 1996 May 01; 169(2):278-87.CI

Abstract

Respiratory virus infections are a serious health challenge. While models exist to study immune mechanisms of the respiratory tract, they have not allowed analysis of the interaction of the lower respiratory tract with other components of the mucosal immune system. This study demonstrates that reovirus 1/Lang, an effective gut mucosal immunogen, also provides a useful model of respiratory mucosal infection. Intra-nasal infection of Balb/c mice resulted in severe viral bronchopneumonia. Major components of the cellular inflammatory response in the lung interstitium and alveolar spaces were CD8 lymphocytes. Lung lymphocyte populations exhibited lysis of reovirus-infected, but not uninfected target cells after in vitro culture. The GCT antigen, a germinal center B-cell and CD8 T-cell marker, was present on 21-60% of the inflammatory lymphocytes. A novel population of GCT-expressing CD4+ lymphocytes unique to reovirus-stimulated lung alveolar and interstitial lymphocyte populations was identified.

Authors+Show Affiliations

Department of Microbiology and Immunology, Medical University of South Carolina, Charleston 29425, USA.No affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Journal Article
Research Support, Non-U.S. Gov't
Research Support, U.S. Gov't, P.H.S.

Language

eng

PubMed ID

8620556

Citation

Thompson, A H., et al. "Respiratory-mucosal Lymphocyte Populations Induced By Reovirus Serotype 1 Infection." Cellular Immunology, vol. 169, no. 2, 1996, pp. 278-87.
Thompson AH, London L, Bellum SC, et al. Respiratory-mucosal lymphocyte populations induced by reovirus serotype 1 infection. Cell Immunol. 1996;169(2):278-87.
Thompson, A. H., London, L., Bellum, S. C., Hamamdzic, D., Harley, R. A., & London, S. D. (1996). Respiratory-mucosal lymphocyte populations induced by reovirus serotype 1 infection. Cellular Immunology, 169(2), 278-87.
Thompson AH, et al. Respiratory-mucosal Lymphocyte Populations Induced By Reovirus Serotype 1 Infection. Cell Immunol. 1996 May 1;169(2):278-87. PubMed PMID: 8620556.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Respiratory-mucosal lymphocyte populations induced by reovirus serotype 1 infection. AU - Thompson,A H, AU - London,L, AU - Bellum,S C, AU - Hamamdzic,D, AU - Harley,R A, AU - London,S D, PY - 1996/5/1/pubmed PY - 1996/5/1/medline PY - 1996/5/1/entrez SP - 278 EP - 87 JF - Cellular immunology JO - Cell Immunol VL - 169 IS - 2 N2 - Respiratory virus infections are a serious health challenge. While models exist to study immune mechanisms of the respiratory tract, they have not allowed analysis of the interaction of the lower respiratory tract with other components of the mucosal immune system. This study demonstrates that reovirus 1/Lang, an effective gut mucosal immunogen, also provides a useful model of respiratory mucosal infection. Intra-nasal infection of Balb/c mice resulted in severe viral bronchopneumonia. Major components of the cellular inflammatory response in the lung interstitium and alveolar spaces were CD8 lymphocytes. Lung lymphocyte populations exhibited lysis of reovirus-infected, but not uninfected target cells after in vitro culture. The GCT antigen, a germinal center B-cell and CD8 T-cell marker, was present on 21-60% of the inflammatory lymphocytes. A novel population of GCT-expressing CD4+ lymphocytes unique to reovirus-stimulated lung alveolar and interstitial lymphocyte populations was identified. SN - 0008-8749 UR - https://www.unboundmedicine.com/medline/citation/8620556/Respiratory_mucosal_lymphocyte_populations_induced_by_reovirus_serotype_1_infection_ L2 - https://linkinghub.elsevier.com/retrieve/pii/S0008-8749(96)90119-7 DB - PRIME DP - Unbound Medicine ER -