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Abortion and breast cancer risk.
Int J Cancer 1996; 65(4):401-5IJ

Abstract

The relationship between spontaneous and induced abortions and breast cancer risk was analyzed using data from a case-control study conducted between June 1991 and February 1994 in 6 Italian centers on 2,569 histologically confirmed incident breast cancer cases and 2,588 controls admitted to hospital for a wide range of acute, non-neoplastic, non-hormone-related diseases. One or more abortions were reported by 31% of cases and 32% of controls, corresponding to a multivariate odds ratio (OR) of 1.0 (95% confidence interval [CI], 0.8-1.1). No trend in risk was observed with increasing number of total abortions or spontaneous and induced abortions separately. No significant relationship was found between the risk of breast cancer and history of spontaneous or induced or total abortions in separate strata of age at diagnosis, number of children, time of abortion in relation to first birth and family history of breast cancer. When abortion was the outcome of the first pregnancy, the OR was 1.2 for spontaneous and 1.3 for induced abortion, in relation to women with birth as outcome of the first pregnancy, and 1.0 and 1.1, respectively, when the reference category was nulligravidae. Thus, our results indicate a lack of association between induced and spontaneous abortions and breast cancer risk.

Authors+Show Affiliations

Istituto di Ricerche Farmacologiche Mario Negri, Milan, Italy.

Pub Type(s)

Journal Article
Research Support, Non-U.S. Gov't

Language

eng

PubMed ID

8621217

Citation

Tavani, A, et al. "Abortion and Breast Cancer Risk." International Journal of Cancer, vol. 65, no. 4, 1996, pp. 401-5.
Tavani A, La Vecchia C, Franceschi S, et al. Abortion and breast cancer risk. Int J Cancer. 1996;65(4):401-5.
Tavani, A., La Vecchia, C., Franceschi, S., Negri, E., D'Avanzo, B., & Decarli, A. (1996). Abortion and breast cancer risk. International Journal of Cancer, 65(4), pp. 401-5.
Tavani A, et al. Abortion and Breast Cancer Risk. Int J Cancer. 1996 Feb 8;65(4):401-5. PubMed PMID: 8621217.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Abortion and breast cancer risk. AU - Tavani,A, AU - La Vecchia,C, AU - Franceschi,S, AU - Negri,E, AU - D'Avanzo,B, AU - Decarli,A, PY - 1996/2/8/pubmed PY - 2000/6/20/medline PY - 1996/2/8/entrez KW - Abortion, Induced KW - Abortion, Spontaneous KW - Age Factors KW - Biology KW - Breast Cancer KW - Cancer KW - Case Control Studies KW - Comparative Studies KW - Demographic Factors KW - Developed Countries KW - Diseases KW - Europe KW - Family Planning KW - Fertility KW - Fertility Control, Postconception KW - Fertility Measurements KW - First Pregnancy Intervals KW - Italy KW - Longitudinal Studies KW - Mediterranean Countries KW - Neoplasms KW - Population KW - Population Characteristics KW - Population Dynamics KW - Pregnancy Complications KW - Pregnancy Intervals KW - Research Methodology KW - Research Report KW - Risk Factors KW - Southern Europe KW - Studies SP - 401 EP - 5 JF - International journal of cancer JO - Int. J. Cancer VL - 65 IS - 4 N2 - The relationship between spontaneous and induced abortions and breast cancer risk was analyzed using data from a case-control study conducted between June 1991 and February 1994 in 6 Italian centers on 2,569 histologically confirmed incident breast cancer cases and 2,588 controls admitted to hospital for a wide range of acute, non-neoplastic, non-hormone-related diseases. One or more abortions were reported by 31% of cases and 32% of controls, corresponding to a multivariate odds ratio (OR) of 1.0 (95% confidence interval [CI], 0.8-1.1). No trend in risk was observed with increasing number of total abortions or spontaneous and induced abortions separately. No significant relationship was found between the risk of breast cancer and history of spontaneous or induced or total abortions in separate strata of age at diagnosis, number of children, time of abortion in relation to first birth and family history of breast cancer. When abortion was the outcome of the first pregnancy, the OR was 1.2 for spontaneous and 1.3 for induced abortion, in relation to women with birth as outcome of the first pregnancy, and 1.0 and 1.1, respectively, when the reference category was nulligravidae. Thus, our results indicate a lack of association between induced and spontaneous abortions and breast cancer risk. SN - 0020-7136 UR - https://www.unboundmedicine.com/medline/citation/8621217/Abortion_and_breast_cancer_risk_ L2 - https://onlinelibrary.wiley.com/resolve/openurl?genre=article&sid=nlm:pubmed&issn=0020-7136&date=1996&volume=65&issue=4&spage=401 DB - PRIME DP - Unbound Medicine ER -