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The effect of simvastatin treatment on natural antioxidants in low-density lipoproteins and high-energy phosphates and ubiquinone in skeletal muscle.
Am J Cardiol. 1996 Apr 15; 77(10):851-4.AJ

Abstract

It has been hypothesized that treating hypercholesterolemic patients with statins will lead not only to a reduction in cholesterol, but also to inhibited synthesis of other compounds which derive from the synthetic pathway of cholesterol. In theory, this could further lead to ubiquinone deficiency in muscle cell mitochondria, disturbing normal cellular respiration and causing adverse effects such as rhabdomyolysis. Furthermore, ubiquinone is one of the lipophilic antioxidants in low-density lipoprotein (LDL), and therefore it has also been hypothesized that statin treatment will reduce the antioxidant capacity of LDL. We investigated the effect of 6 months of simvastatin treatment (20 mg/day) on skeletal muscle concentrations of high-energy phosphates and ubiquinone by performing biopsies in 19 hypercholesterolemic patients. Parallel assays were performed in untreated control subjects. The muscle high-energy phosphate and ubiquinone concentrations assayed after simvastatin treatment were similar to those observed at baseline and did not differ from the values obtained in control subjects at the beginning and end of follow-up. These results do not support the hypothesis of diminished isoprenoid synthesis or energy generation in muscle cells during simvastatin treatment. Furthermore, the results of analysis of antioxidant concentrations in LDL before and after simvastatin treatment indicate that the antioxidant capacity of LDL is maintained in simvastatin-treated patients.

Authors+Show Affiliations

Department of Clinical Pharmacology, University of Helskini, Finland.No affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Journal Article
Research Support, Non-U.S. Gov't

Language

eng

PubMed ID

8623738

Citation

Laaksonen, R, et al. "The Effect of Simvastatin Treatment On Natural Antioxidants in Low-density Lipoproteins and High-energy Phosphates and Ubiquinone in Skeletal Muscle." The American Journal of Cardiology, vol. 77, no. 10, 1996, pp. 851-4.
Laaksonen R, Jokelainen K, Laakso J, et al. The effect of simvastatin treatment on natural antioxidants in low-density lipoproteins and high-energy phosphates and ubiquinone in skeletal muscle. Am J Cardiol. 1996;77(10):851-4.
Laaksonen, R., Jokelainen, K., Laakso, J., Sahi, T., Harkonen, M., Tikkanen, M. J., & Himberg, J. J. (1996). The effect of simvastatin treatment on natural antioxidants in low-density lipoproteins and high-energy phosphates and ubiquinone in skeletal muscle. The American Journal of Cardiology, 77(10), 851-4.
Laaksonen R, et al. The Effect of Simvastatin Treatment On Natural Antioxidants in Low-density Lipoproteins and High-energy Phosphates and Ubiquinone in Skeletal Muscle. Am J Cardiol. 1996 Apr 15;77(10):851-4. PubMed PMID: 8623738.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - The effect of simvastatin treatment on natural antioxidants in low-density lipoproteins and high-energy phosphates and ubiquinone in skeletal muscle. AU - Laaksonen,R, AU - Jokelainen,K, AU - Laakso,J, AU - Sahi,T, AU - Harkonen,M, AU - Tikkanen,M J, AU - Himberg,J J, PY - 1996/4/15/pubmed PY - 1996/4/15/medline PY - 1996/4/15/entrez SP - 851 EP - 4 JF - The American journal of cardiology JO - Am J Cardiol VL - 77 IS - 10 N2 - It has been hypothesized that treating hypercholesterolemic patients with statins will lead not only to a reduction in cholesterol, but also to inhibited synthesis of other compounds which derive from the synthetic pathway of cholesterol. In theory, this could further lead to ubiquinone deficiency in muscle cell mitochondria, disturbing normal cellular respiration and causing adverse effects such as rhabdomyolysis. Furthermore, ubiquinone is one of the lipophilic antioxidants in low-density lipoprotein (LDL), and therefore it has also been hypothesized that statin treatment will reduce the antioxidant capacity of LDL. We investigated the effect of 6 months of simvastatin treatment (20 mg/day) on skeletal muscle concentrations of high-energy phosphates and ubiquinone by performing biopsies in 19 hypercholesterolemic patients. Parallel assays were performed in untreated control subjects. The muscle high-energy phosphate and ubiquinone concentrations assayed after simvastatin treatment were similar to those observed at baseline and did not differ from the values obtained in control subjects at the beginning and end of follow-up. These results do not support the hypothesis of diminished isoprenoid synthesis or energy generation in muscle cells during simvastatin treatment. Furthermore, the results of analysis of antioxidant concentrations in LDL before and after simvastatin treatment indicate that the antioxidant capacity of LDL is maintained in simvastatin-treated patients. SN - 0002-9149 UR - https://www.unboundmedicine.com/medline/citation/8623738/The_effect_of_simvastatin_treatment_on_natural_antioxidants_in_low_density_lipoproteins_and_high_energy_phosphates_and_ubiquinone_in_skeletal_muscle_ L2 - https://linkinghub.elsevier.com/retrieve/pii/S0002-9149(97)89180-1 DB - PRIME DP - Unbound Medicine ER -