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A prospective study of reproductive factors and risk of epithelial ovarian cancer.
Cancer 1995; 76(2):284-90C

Abstract

BACKGROUND

Parity and long term use of oral contraceptives have been associated consistently with a decreased risk of ovarian cancer. However, previous reports of the relationship of other reproductive factors (time since first use or last use of oral contraceptives, age at menarche or menopause, age at first birth) with ovarian cancer have been inconsistent.

METHODS

The authors studied these relationships in the Nurses' Health Study, a prospective cohort study of 121,700 female registered nurses aged 30-55 years in 1976 when the study began. From 1976 to 1988, 260 cases of confirmed epithelial ovarian cancer occurred among 1.2 million person-years of follow-up.

RESULTS

A statistically significant inverse association was observed between parity and ovarian cancer risk (relative risk [RR] = 0.84; 95% confidence interval [CI] = 0.77-0.91 per pregnancy); age at first birth was not associated independently with risk. In age-adjusted analyses, a significant inverse association was noted between long term use of oral contraceptives and ovarian cancer, which was no longer significant after controlling for other ovarian cancer risk factors (RR with > or = 5 years' use: 0.65; 95% CI = 0.40-1.05). After control for duration of use, a weak nonsignificant inverse association was observed with time since first oral contraceptive use and no independent effect of time since last use. Neither age at menarche nor age at menopause was associated significantly with ovarian cancer risk.

CONCLUSIONS

In this large prospective study, parity was the only reproductive factor that had a substantial independent association with ovarian cancer. Long term oral contraceptive use also appeared to have an inverse relationship with ovarian cancer, although this association was of borderline significance (P = 0.11) after adjustment for other risk factors.

Authors+Show Affiliations

Channing Laboratory, Brigham and Women's Hospital, Harvard Medical School, Boston, MA, USA.No affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Journal Article
Research Support, U.S. Gov't, P.H.S.

Language

eng

PubMed ID

8625104

Citation

Hankinson, S E., et al. "A Prospective Study of Reproductive Factors and Risk of Epithelial Ovarian Cancer." Cancer, vol. 76, no. 2, 1995, pp. 284-90.
Hankinson SE, Colditz GA, Hunter DJ, et al. A prospective study of reproductive factors and risk of epithelial ovarian cancer. Cancer. 1995;76(2):284-90.
Hankinson, S. E., Colditz, G. A., Hunter, D. J., Willett, W. C., Stampfer, M. J., Rosner, B., ... Speizer, F. E. (1995). A prospective study of reproductive factors and risk of epithelial ovarian cancer. Cancer, 76(2), pp. 284-90.
Hankinson SE, et al. A Prospective Study of Reproductive Factors and Risk of Epithelial Ovarian Cancer. Cancer. 1995 Jul 15;76(2):284-90. PubMed PMID: 8625104.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - A prospective study of reproductive factors and risk of epithelial ovarian cancer. AU - Hankinson,S E, AU - Colditz,G A, AU - Hunter,D J, AU - Willett,W C, AU - Stampfer,M J, AU - Rosner,B, AU - Hennekens,C H, AU - Speizer,F E, PY - 1995/7/15/pubmed PY - 1995/7/15/medline PY - 1995/7/15/entrez SP - 284 EP - 90 JF - Cancer JO - Cancer VL - 76 IS - 2 N2 - BACKGROUND: Parity and long term use of oral contraceptives have been associated consistently with a decreased risk of ovarian cancer. However, previous reports of the relationship of other reproductive factors (time since first use or last use of oral contraceptives, age at menarche or menopause, age at first birth) with ovarian cancer have been inconsistent. METHODS: The authors studied these relationships in the Nurses' Health Study, a prospective cohort study of 121,700 female registered nurses aged 30-55 years in 1976 when the study began. From 1976 to 1988, 260 cases of confirmed epithelial ovarian cancer occurred among 1.2 million person-years of follow-up. RESULTS: A statistically significant inverse association was observed between parity and ovarian cancer risk (relative risk [RR] = 0.84; 95% confidence interval [CI] = 0.77-0.91 per pregnancy); age at first birth was not associated independently with risk. In age-adjusted analyses, a significant inverse association was noted between long term use of oral contraceptives and ovarian cancer, which was no longer significant after controlling for other ovarian cancer risk factors (RR with > or = 5 years' use: 0.65; 95% CI = 0.40-1.05). After control for duration of use, a weak nonsignificant inverse association was observed with time since first oral contraceptive use and no independent effect of time since last use. Neither age at menarche nor age at menopause was associated significantly with ovarian cancer risk. CONCLUSIONS: In this large prospective study, parity was the only reproductive factor that had a substantial independent association with ovarian cancer. Long term oral contraceptive use also appeared to have an inverse relationship with ovarian cancer, although this association was of borderline significance (P = 0.11) after adjustment for other risk factors. SN - 0008-543X UR - https://www.unboundmedicine.com/medline/citation/8625104/full_citation L2 - http://www.diseaseinfosearch.org/result/5509 DB - PRIME DP - Unbound Medicine ER -