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Case-control study of idiopathic Parkinson's disease and dietary vitamin E intake.
Neurology. 1996 May; 46(5):1270-4.Neur

Abstract

A nested case-control study of 84 incident cases of patients with idiopathic Parkinson's disease (PD) detected by June 30, 1994 and 336 age-matched control subjects, compared previously-documented intake of total dietary vitamin E and of selected vitamin E-containing foods. All study subjects had been followed for 27 to 30 years after diet recording in the 8,006-man Honolulu Heart Study cohort. We determined PD outcomes by periodic cohort re-examination and neurologic testing, private physician reports, examination of O'ahu neurologists' office records, and continual death certificate and hospital discharge diagnosis surveillance. Data on vitamin E intake, obtained from three dietary data sets at the time of cohort enrollment (1965 to 1968), included a food-frequency questionnaire and a 24-hour photograph-assisted dietary recall administered by trained dietitians. Although absence of PD was significantly associated with prior consumption of legumes (adjusted OR = 0.27, 95% CI 0.09 to 0.78), a dietary variable preselected for high vitamin E content, neither food categories nor quartiles nor continuous variables of vitamin E consumption were significantly associated with PD occurrence. Though consistent with prior reports of PD protection afforded by legumes, and with speculation on the possible benefits of dietary or supplemental vitamin E in preventing PD, these preliminary data do not conclusively document a beneficial effect of dietary vitamin E on PD occurrence.

Authors+Show Affiliations

Department of Public Health Sciences, School of Public Health, University of Hawai'i, Honolulu 96822, USA.No affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Comparative Study
Journal Article
Multicenter Study
Research Support, Non-U.S. Gov't
Research Support, U.S. Gov't, P.H.S.

Language

eng

PubMed ID

8628465

Citation

Morens, D M., et al. "Case-control Study of Idiopathic Parkinson's Disease and Dietary Vitamin E Intake." Neurology, vol. 46, no. 5, 1996, pp. 1270-4.
Morens DM, Grandinetti A, Waslien CI, et al. Case-control study of idiopathic Parkinson's disease and dietary vitamin E intake. Neurology. 1996;46(5):1270-4.
Morens, D. M., Grandinetti, A., Waslien, C. I., Park, C. B., Ross, G. W., & White, L. R. (1996). Case-control study of idiopathic Parkinson's disease and dietary vitamin E intake. Neurology, 46(5), 1270-4.
Morens DM, et al. Case-control Study of Idiopathic Parkinson's Disease and Dietary Vitamin E Intake. Neurology. 1996;46(5):1270-4. PubMed PMID: 8628465.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Case-control study of idiopathic Parkinson's disease and dietary vitamin E intake. AU - Morens,D M, AU - Grandinetti,A, AU - Waslien,C I, AU - Park,C B, AU - Ross,G W, AU - White,L R, PY - 1996/5/1/pubmed PY - 1996/5/1/medline PY - 1996/5/1/entrez SP - 1270 EP - 4 JF - Neurology JO - Neurology VL - 46 IS - 5 N2 - A nested case-control study of 84 incident cases of patients with idiopathic Parkinson's disease (PD) detected by June 30, 1994 and 336 age-matched control subjects, compared previously-documented intake of total dietary vitamin E and of selected vitamin E-containing foods. All study subjects had been followed for 27 to 30 years after diet recording in the 8,006-man Honolulu Heart Study cohort. We determined PD outcomes by periodic cohort re-examination and neurologic testing, private physician reports, examination of O'ahu neurologists' office records, and continual death certificate and hospital discharge diagnosis surveillance. Data on vitamin E intake, obtained from three dietary data sets at the time of cohort enrollment (1965 to 1968), included a food-frequency questionnaire and a 24-hour photograph-assisted dietary recall administered by trained dietitians. Although absence of PD was significantly associated with prior consumption of legumes (adjusted OR = 0.27, 95% CI 0.09 to 0.78), a dietary variable preselected for high vitamin E content, neither food categories nor quartiles nor continuous variables of vitamin E consumption were significantly associated with PD occurrence. Though consistent with prior reports of PD protection afforded by legumes, and with speculation on the possible benefits of dietary or supplemental vitamin E in preventing PD, these preliminary data do not conclusively document a beneficial effect of dietary vitamin E on PD occurrence. SN - 0028-3878 UR - https://www.unboundmedicine.com/medline/citation/8628465/Case_control_study_of_idiopathic_Parkinson's_disease_and_dietary_vitamin_E_intake_ L2 - http://ovidsp.ovid.com/ovidweb.cgi?T=JS&PAGE=linkout&SEARCH=8628465.ui DB - PRIME DP - Unbound Medicine ER -