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Influence of digitalis on left ventricular functional response to exercise in congestive heart failure.
Am J Cardiol. 1996 Mar 01; 77(7):480-5.AJ

Abstract

This was a double-blind, placebo-controlled, crossover study designed to determine the influence of digitalis treatment on left ventricular (LV) response to physical exercise in patients with congestive heart failure (CHF). In 10 patients with CHF (ejection fraction 29 +/- 2%), LV function was assessed during upright bicycle exercise using an ambulatory radionuclide detector for continuous noninvasive monitoring of cardiac function. Exercise was performed during control conditions and after a 3-week treatment with digoxin (0.25 mg/day orally) or placebo. Ten normal volunteers matched for sex and age constituted the control group. In normals, exercise ejection fraction and end-diastolic volume increased (both p <0.001), while end-systolic volume decreased progressively (p <0.001). In control conditions, patients with CHF had a sharp increase in heart rate during exercise, while ejection fraction did not change; both end-diastolic and end-systolic volumes increased significantly (both p <0.001) during exercise. During digoxin treatment, heart rate response to exercise recorded in patients with CHF was comparable to that recorded in normal subjects. In addition, a significant increase in ejection fraction during exercise was detected (P <0.001), and the increase in end-systolic volume was significantly smaller than that observed in control conditions (p <0.05). When patients received placebo, the responses of LV function to exercise were comparable to those observed in control conditions. These findings demonstrate that digitalis has a favorable influence on LV functional adaptation to exercise in CHF.

Authors+Show Affiliations

Department of Internal Medicine, Federico II University, Naples, Italy.No affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Clinical Trial
Journal Article
Randomized Controlled Trial

Language

eng

PubMed ID

8629588

Citation

Morisco, C, et al. "Influence of Digitalis On Left Ventricular Functional Response to Exercise in Congestive Heart Failure." The American Journal of Cardiology, vol. 77, no. 7, 1996, pp. 480-5.
Morisco C, Cuocolo A, Romano M, et al. Influence of digitalis on left ventricular functional response to exercise in congestive heart failure. Am J Cardiol. 1996;77(7):480-5.
Morisco, C., Cuocolo, A., Romano, M., Nappi, A., Iaccarino, G., Volpe, M., Salvatore, M., & Trimarco, B. (1996). Influence of digitalis on left ventricular functional response to exercise in congestive heart failure. The American Journal of Cardiology, 77(7), 480-5.
Morisco C, et al. Influence of Digitalis On Left Ventricular Functional Response to Exercise in Congestive Heart Failure. Am J Cardiol. 1996 Mar 1;77(7):480-5. PubMed PMID: 8629588.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Influence of digitalis on left ventricular functional response to exercise in congestive heart failure. AU - Morisco,C, AU - Cuocolo,A, AU - Romano,M, AU - Nappi,A, AU - Iaccarino,G, AU - Volpe,M, AU - Salvatore,M, AU - Trimarco,B, PY - 1996/3/1/pubmed PY - 1996/3/1/medline PY - 1996/3/1/entrez SP - 480 EP - 5 JF - The American journal of cardiology JO - Am. J. Cardiol. VL - 77 IS - 7 N2 - This was a double-blind, placebo-controlled, crossover study designed to determine the influence of digitalis treatment on left ventricular (LV) response to physical exercise in patients with congestive heart failure (CHF). In 10 patients with CHF (ejection fraction 29 +/- 2%), LV function was assessed during upright bicycle exercise using an ambulatory radionuclide detector for continuous noninvasive monitoring of cardiac function. Exercise was performed during control conditions and after a 3-week treatment with digoxin (0.25 mg/day orally) or placebo. Ten normal volunteers matched for sex and age constituted the control group. In normals, exercise ejection fraction and end-diastolic volume increased (both p <0.001), while end-systolic volume decreased progressively (p <0.001). In control conditions, patients with CHF had a sharp increase in heart rate during exercise, while ejection fraction did not change; both end-diastolic and end-systolic volumes increased significantly (both p <0.001) during exercise. During digoxin treatment, heart rate response to exercise recorded in patients with CHF was comparable to that recorded in normal subjects. In addition, a significant increase in ejection fraction during exercise was detected (P <0.001), and the increase in end-systolic volume was significantly smaller than that observed in control conditions (p <0.05). When patients received placebo, the responses of LV function to exercise were comparable to those observed in control conditions. These findings demonstrate that digitalis has a favorable influence on LV functional adaptation to exercise in CHF. SN - 0002-9149 UR - https://www.unboundmedicine.com/medline/citation/8629588/Influence_of_digitalis_on_left_ventricular_functional_response_to_exercise_in_congestive_heart_failure_ L2 - https://linkinghub.elsevier.com/retrieve/pii/S0002-9149(97)89341-1 DB - PRIME DP - Unbound Medicine ER -