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Familial prostate cancer in Sweden. A nationwide register cohort study.
Cancer. 1996 Jan 01; 77(1):138-43.C

Abstract

BACKGROUND

Although prostate carcinoma is not widely recognized as a familial cancer, familial aggregation of this disease has been shown in some retrospective case-control studies. To study familial prostate cancer in Sweden, a population-based cohort study was performed, that attempted to avoid possible bias connected with some earlier studies of familial prostate cancer.

METHODS

A nationwide register cohort study was conducted using an unselected study population. The study cohort of 5496 sons of Swedish men found to have prostate cancer between 1959 and 1963 was identified through parish offices. All prostate cancer patients reported between 1958 and 1990 in this cohort were identified through linkage to the Swedish Cancer Register. The expected number of prostate cancer patients was calculated using incidence rates obtained from the same register.

RESULTS

A highly significant increased overall standardized incidence ratio (SIR) of 1.70 (95% confidence interval, 1.51-1.90) was obtained for prostate cancer in this cohort, with 302 observed cases compared with 178 expected prostate cancers. The SIR was 3.38 among patients aged 45-49 years at diagnosis, with the risk gradually decreasing to a SIR of 1.35 among patients older than 80 years (trend, P = 0.013). Among sons with a father whose prostate cancer was diagnosed at an early age (< 70 years), a significant trend (P = 0.01) for prostate cancer risk was observed due to early onset of the disease.

CONCLUSIONS

This cohort study provides further evidence that a positive family history of prostate cancer is a risk factor for developing the disease in an unselected population. The increased risk was found for all ages, but was more pronounced in younger men.

Authors+Show Affiliations

Department of Oncology, Umeå University, Sweden.No affiliation info availableNo affiliation info available

Pub Type(s)

Journal Article
Research Support, Non-U.S. Gov't
Review

Language

eng

PubMed ID

8630920

Citation

Grönberg, H, et al. "Familial Prostate Cancer in Sweden. a Nationwide Register Cohort Study." Cancer, vol. 77, no. 1, 1996, pp. 138-43.
Grönberg H, Damber L, Damber JE. Familial prostate cancer in Sweden. A nationwide register cohort study. Cancer. 1996;77(1):138-43.
Grönberg, H., Damber, L., & Damber, J. E. (1996). Familial prostate cancer in Sweden. A nationwide register cohort study. Cancer, 77(1), 138-43.
Grönberg H, Damber L, Damber JE. Familial Prostate Cancer in Sweden. a Nationwide Register Cohort Study. Cancer. 1996 Jan 1;77(1):138-43. PubMed PMID: 8630920.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Familial prostate cancer in Sweden. A nationwide register cohort study. AU - Grönberg,H, AU - Damber,L, AU - Damber,J E, PY - 1996/1/1/pubmed PY - 2000/6/20/medline PY - 1996/1/1/entrez SP - 138 EP - 43 JF - Cancer JO - Cancer VL - 77 IS - 1 N2 - BACKGROUND: Although prostate carcinoma is not widely recognized as a familial cancer, familial aggregation of this disease has been shown in some retrospective case-control studies. To study familial prostate cancer in Sweden, a population-based cohort study was performed, that attempted to avoid possible bias connected with some earlier studies of familial prostate cancer. METHODS: A nationwide register cohort study was conducted using an unselected study population. The study cohort of 5496 sons of Swedish men found to have prostate cancer between 1959 and 1963 was identified through parish offices. All prostate cancer patients reported between 1958 and 1990 in this cohort were identified through linkage to the Swedish Cancer Register. The expected number of prostate cancer patients was calculated using incidence rates obtained from the same register. RESULTS: A highly significant increased overall standardized incidence ratio (SIR) of 1.70 (95% confidence interval, 1.51-1.90) was obtained for prostate cancer in this cohort, with 302 observed cases compared with 178 expected prostate cancers. The SIR was 3.38 among patients aged 45-49 years at diagnosis, with the risk gradually decreasing to a SIR of 1.35 among patients older than 80 years (trend, P = 0.013). Among sons with a father whose prostate cancer was diagnosed at an early age (< 70 years), a significant trend (P = 0.01) for prostate cancer risk was observed due to early onset of the disease. CONCLUSIONS: This cohort study provides further evidence that a positive family history of prostate cancer is a risk factor for developing the disease in an unselected population. The increased risk was found for all ages, but was more pronounced in younger men. SN - 0008-543X UR - https://www.unboundmedicine.com/medline/citation/8630920/Familial_prostate_cancer_in_Sweden__A_nationwide_register_cohort_study_ L2 - http://www.diseaseinfosearch.org/result/2768 DB - PRIME DP - Unbound Medicine ER -