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[HIV-associated Pneumocystis carinii pneumonia, primary pentamidine inhalation prophylaxis notwithstanding. Are there differences with Pneumocystis carinii pneumonia without prophylaxis?].
Dtsch Med Wochenschr. 1996 Jan 26; 121(4):83-9.DM

Abstract

OBJECTIVE

To study the effect of pentamidine aerosol inhalation, known to be effective and well tolerated in the primary prevention of HIV-associated Pneumocystis carinii pneumonia (PCP), on the severity, on clinical and radiological findings and prognosis of break-through PCP.

PATIENTS AND METHODS

Data were obtained from the case notes of 17 men (mean age 36 [23-55] years) with HIV-associated PCP, treated between 1989 and 1994, who had received primary prophylaxis with pentamidine aerosol. During the same period 42 patients with HIV-associated PCP but no pentamidine prophylaxis (39 men, three women; mean age 36 [21-67] years) were also treated. Bronchoalveolar lavage of the most affected segment was performed. Diagnostic measures and treatment remained constant during the period of observation.

RESULTS

The clinical presentation was the same in the two groups. There was also no difference between them regarding sensitivity to the lavage (94 and 98%). However, infiltration of the upper segments was significantly more common in the prophylaxis group (90 and 43%; P < 0.02). There was no statistically significant difference between the two groups in death rate (13 and 7%) and the long-term prognosis after PCP (survival time 18 and 24 months, respectively).

CONCLUSION

Primary prophylaxis of PCP had no significant effect other than altering the distribution pattern of the pneumonic infiltrates towards the apical segments.

Authors+Show Affiliations

Ewig S
Medizinische Universitätsklinik und Poliklinik sowie Radiologische Universitätsklinik Bonn.
Rockstroh JK
No affiliation info available
Schäfer H
No affiliation info available
Leutner C
No affiliation info available
Pickenhain A
No affiliation info available
Lüderitz B
No affiliation info available

MeSH

Acquired Immunodeficiency SyndromeAdultAerosolsAgedAntifungal AgentsFemaleHumansMaleMiddle AgedPentamidinePneumonia, PneumocystisRespiratory TherapyTime FactorsTomography, X-Ray Computed

Pub Type(s)

Comparative Study
English Abstract
Journal Article

Language

ger

PubMed ID

8631243

Citation

Ewig, S, et al. "[HIV-associated Pneumocystis Carinii Pneumonia, Primary Pentamidine Inhalation Prophylaxis Notwithstanding. Are There Differences With Pneumocystis Carinii Pneumonia Without Prophylaxis?]." Deutsche Medizinische Wochenschrift (1946), vol. 121, no. 4, 1996, pp. 83-9.
Ewig S, Rockstroh JK, Schäfer H, et al. [HIV-associated Pneumocystis carinii pneumonia, primary pentamidine inhalation prophylaxis notwithstanding. Are there differences with Pneumocystis carinii pneumonia without prophylaxis?]. Dtsch Med Wochenschr. 1996;121(4):83-9.
Ewig, S., Rockstroh, J. K., Schäfer, H., Leutner, C., Pickenhain, A., & Lüderitz, B. (1996). [HIV-associated Pneumocystis carinii pneumonia, primary pentamidine inhalation prophylaxis notwithstanding. Are there differences with Pneumocystis carinii pneumonia without prophylaxis?]. Deutsche Medizinische Wochenschrift (1946), 121(4), 83-9.
Ewig S, et al. [HIV-associated Pneumocystis Carinii Pneumonia, Primary Pentamidine Inhalation Prophylaxis Notwithstanding. Are There Differences With Pneumocystis Carinii Pneumonia Without Prophylaxis?]. Dtsch Med Wochenschr. 1996 Jan 26;121(4):83-9. PubMed PMID: 8631243.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - [HIV-associated Pneumocystis carinii pneumonia, primary pentamidine inhalation prophylaxis notwithstanding. Are there differences with Pneumocystis carinii pneumonia without prophylaxis?]. AU - Ewig,S, AU - Rockstroh,J K, AU - Schäfer,H, AU - Leutner,C, AU - Pickenhain,A, AU - Lüderitz,B, PY - 1996/1/26/pubmed PY - 1996/1/26/medline PY - 1996/1/26/entrez SP - 83 EP - 9 JF - Deutsche medizinische Wochenschrift (1946) JO - Dtsch Med Wochenschr VL - 121 IS - 4 N2 - OBJECTIVE: To study the effect of pentamidine aerosol inhalation, known to be effective and well tolerated in the primary prevention of HIV-associated Pneumocystis carinii pneumonia (PCP), on the severity, on clinical and radiological findings and prognosis of break-through PCP. PATIENTS AND METHODS: Data were obtained from the case notes of 17 men (mean age 36 [23-55] years) with HIV-associated PCP, treated between 1989 and 1994, who had received primary prophylaxis with pentamidine aerosol. During the same period 42 patients with HIV-associated PCP but no pentamidine prophylaxis (39 men, three women; mean age 36 [21-67] years) were also treated. Bronchoalveolar lavage of the most affected segment was performed. Diagnostic measures and treatment remained constant during the period of observation. RESULTS: The clinical presentation was the same in the two groups. There was also no difference between them regarding sensitivity to the lavage (94 and 98%). However, infiltration of the upper segments was significantly more common in the prophylaxis group (90 and 43%; P < 0.02). There was no statistically significant difference between the two groups in death rate (13 and 7%) and the long-term prognosis after PCP (survival time 18 and 24 months, respectively). CONCLUSION: Primary prophylaxis of PCP had no significant effect other than altering the distribution pattern of the pneumonic infiltrates towards the apical segments. SN - 0012-0472 UR - https://www.unboundmedicine.com/medline/citation/8631243/[HIV_associated_Pneumocystis_carinii_pneumonia_primary_pentamidine_inhalation_prophylaxis_notwithstanding__Are_there_differences_with_Pneumocystis_carinii_pneumonia_without_prophylaxis]_ DB - PRIME DP - Unbound Medicine ER -