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Preoperative evaluation of D-dimer and CA 125 levels in differentiating benign from malignant ovarian masses.
Gynecol Oncol. 1996 Feb; 60(2):197-202.GO

Abstract

Plasma levels of D-dimer (DD) and CA 125 were measured preoperatively in 121 patients with ovarian masses submitted to laparotomy. DD and CA 125 levels were higher in the 56 patients with epithelial ovarian cancer than in the 65 patients with benign ovarian disease (P < 0.0001). The logistic regression procedure showed that both DD assay (cutoff 416 ng/ml) and CA 125 assay (cutoff 65 U/ml) were significant predictive variables for malignancy (P = 0.0001). The concordance between predicted probabilities and observed responses was 75.7% for DD, 72.1% for CA 125, and 90.8% for Dd and CA 125. It is worth noting that DD was increased (> 416 ng/ml) in 73% of FIGO stage I patients, whereas CA 125 was above 65 U/ml in only 33.3%. Sensitivity, specificity, positive predictive value, and negative predictive value of the tests in differentiating benign from malignant ovarian masses were as follows: 76.8, 93.8, 91.5, and 82.4%, respectively, for CA 125; 94.6, 76.9, 77.9, and 94.3%, respectively, for the combination CA 125 or DD; and 73.2, 100.0, 100.0, and 81.3%, respectively, for the combination CA 125 and DD. The combination CA 125 and DD seems to be a useful diagnostic tool to differentiate benign from malignant ovarian masses. Elevated preoperative levels of both antigens are invariably associated with a postsurgical diagnosis of epithelial ovarian cancer.

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Authors+Show Affiliations

Gadducci A
Department of Gynecology and Obstetrics, University of Pisa, Italy.
Baicchi U
No affiliation info available
Marrai R
No affiliation info available
Ferdeghini M
No affiliation info available
Bianchi R
No affiliation info available
Facchini V
No affiliation info available

MeSH

AdultAgedAged, 80 and overCA-125 AntigenDiagnosis, DifferentialFemaleFibrin Fibrinogen Degradation ProductsHumansMiddle AgedNeoplasm StagingOvarian DiseasesOvarian NeoplasmsPredictive Value of TestsPreoperative CareRegression Analysis

Pub Type(s)

Journal Article

Language

eng

PubMed ID

8631538

Citation

Gadducci, A, et al. "Preoperative Evaluation of D-dimer and CA 125 Levels in Differentiating Benign From Malignant Ovarian Masses." Gynecologic Oncology, vol. 60, no. 2, 1996, pp. 197-202.
Gadducci A, Baicchi U, Marrai R, et al. Preoperative evaluation of D-dimer and CA 125 levels in differentiating benign from malignant ovarian masses. Gynecol Oncol. 1996;60(2):197-202.
Gadducci, A., Baicchi, U., Marrai, R., Ferdeghini, M., Bianchi, R., & Facchini, V. (1996). Preoperative evaluation of D-dimer and CA 125 levels in differentiating benign from malignant ovarian masses. Gynecologic Oncology, 60(2), 197-202.
Gadducci A, et al. Preoperative Evaluation of D-dimer and CA 125 Levels in Differentiating Benign From Malignant Ovarian Masses. Gynecol Oncol. 1996;60(2):197-202. PubMed PMID: 8631538.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Preoperative evaluation of D-dimer and CA 125 levels in differentiating benign from malignant ovarian masses. AU - Gadducci,A, AU - Baicchi,U, AU - Marrai,R, AU - Ferdeghini,M, AU - Bianchi,R, AU - Facchini,V, PY - 1996/2/1/pubmed PY - 1996/2/1/medline PY - 1996/2/1/entrez SP - 197 EP - 202 JF - Gynecologic oncology JO - Gynecol Oncol VL - 60 IS - 2 N2 - Plasma levels of D-dimer (DD) and CA 125 were measured preoperatively in 121 patients with ovarian masses submitted to laparotomy. DD and CA 125 levels were higher in the 56 patients with epithelial ovarian cancer than in the 65 patients with benign ovarian disease (P < 0.0001). The logistic regression procedure showed that both DD assay (cutoff 416 ng/ml) and CA 125 assay (cutoff 65 U/ml) were significant predictive variables for malignancy (P = 0.0001). The concordance between predicted probabilities and observed responses was 75.7% for DD, 72.1% for CA 125, and 90.8% for Dd and CA 125. It is worth noting that DD was increased (> 416 ng/ml) in 73% of FIGO stage I patients, whereas CA 125 was above 65 U/ml in only 33.3%. Sensitivity, specificity, positive predictive value, and negative predictive value of the tests in differentiating benign from malignant ovarian masses were as follows: 76.8, 93.8, 91.5, and 82.4%, respectively, for CA 125; 94.6, 76.9, 77.9, and 94.3%, respectively, for the combination CA 125 or DD; and 73.2, 100.0, 100.0, and 81.3%, respectively, for the combination CA 125 and DD. The combination CA 125 and DD seems to be a useful diagnostic tool to differentiate benign from malignant ovarian masses. Elevated preoperative levels of both antigens are invariably associated with a postsurgical diagnosis of epithelial ovarian cancer. SN - 0090-8258 UR - https://www.unboundmedicine.com/medline/citation/8631538/Preoperative_evaluation_of_D_dimer_and_CA_125_levels_in_differentiating_benign_from_malignant_ovarian_masses_ L2 - https://linkinghub.elsevier.com/retrieve/pii/S0090-8258(96)90025-6 DB - PRIME DP - Unbound Medicine ER -