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Glutathione S-transferase M1 genotype and age-related cataracts. Lack of association in an Italian population.
Invest Ophthalmol Vis Sci. 1996 May; 37(6):1167-73.IO

Abstract

PURPOSE

To investigate possible associations between the gene number and allelic forms of glutathione S-transferase M1 (GSTM1) and the occurrence of nucleic and cortical age-related cataracts.

METHODS

Patients with cortical cataract, nuclear cataract, mixed and cortical cataract, and no cataract were sytematically selected from subjects evaluated in the Italian-American Study of the Natural History of Age-Related Cataract. The patients were typed for the A, B, and null alleles of GSTM1 using a variation of the amplification refractory mutation system.

RESULTS

Forty-nine percent of patients (50/102) with cortical cataracts, 45% (13/29) with nuclear cataracts, 51% (36/71) with mixed nuclear and cortical cataracts, and 50% of controls (49/98) were homozygous for the null GSTM1 allele. Twenty-five percent of patients (26/102) with cortical cataracts, 24% (7/29) with nuclear cataracts, 31% with mixed nuclear and cortical cataracts, and 27% of controls (26/98) displayed only the A allele for GSTM1. Twenty-four percent of patients (24/102) with cortical cataract, 24% (7/29) with nuclear cataracts, 14% (10/71) with mixed nuclear and cortical cataract, and 18% of controls showed only the B allele for GSTM1. Two percent of patients (2/102) with cortical cataracts, 7% (2/29) with nuclear cataracts, 4% (3/71) with mixed nuclear and cortical cataracts, and 5% of controls (5/98) showed both A and B alleles for GSTM1.

CONCLUSIONS

No associations between the GSTM1 alleles, including the null allele, and cataracts were detected in this study.

Authors+Show Affiliations

Institute of Ophthalmology, University of Parma, Italy.No affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Journal Article

Language

eng

PubMed ID

8631631

Citation

Alberti, G, et al. "Glutathione S-transferase M1 Genotype and Age-related Cataracts. Lack of Association in an Italian Population." Investigative Ophthalmology & Visual Science, vol. 37, no. 6, 1996, pp. 1167-73.
Alberti G, Oguni M, Podgor M, et al. Glutathione S-transferase M1 genotype and age-related cataracts. Lack of association in an Italian population. Invest Ophthalmol Vis Sci. 1996;37(6):1167-73.
Alberti, G., Oguni, M., Podgor, M., Sperduto, R. D., Tomarev, S., Grassi, C., Williams, S., Kaiser-Kupfer, M., Maraini, G., & Hejtmancik, J. F. (1996). Glutathione S-transferase M1 genotype and age-related cataracts. Lack of association in an Italian population. Investigative Ophthalmology & Visual Science, 37(6), 1167-73.
Alberti G, et al. Glutathione S-transferase M1 Genotype and Age-related Cataracts. Lack of Association in an Italian Population. Invest Ophthalmol Vis Sci. 1996;37(6):1167-73. PubMed PMID: 8631631.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Glutathione S-transferase M1 genotype and age-related cataracts. Lack of association in an Italian population. AU - Alberti,G, AU - Oguni,M, AU - Podgor,M, AU - Sperduto,R D, AU - Tomarev,S, AU - Grassi,C, AU - Williams,S, AU - Kaiser-Kupfer,M, AU - Maraini,G, AU - Hejtmancik,J F, PY - 1996/5/1/pubmed PY - 1996/5/1/medline PY - 1996/5/1/entrez SP - 1167 EP - 73 JF - Investigative ophthalmology & visual science JO - Invest. Ophthalmol. Vis. Sci. VL - 37 IS - 6 N2 - PURPOSE: To investigate possible associations between the gene number and allelic forms of glutathione S-transferase M1 (GSTM1) and the occurrence of nucleic and cortical age-related cataracts. METHODS: Patients with cortical cataract, nuclear cataract, mixed and cortical cataract, and no cataract were sytematically selected from subjects evaluated in the Italian-American Study of the Natural History of Age-Related Cataract. The patients were typed for the A, B, and null alleles of GSTM1 using a variation of the amplification refractory mutation system. RESULTS: Forty-nine percent of patients (50/102) with cortical cataracts, 45% (13/29) with nuclear cataracts, 51% (36/71) with mixed nuclear and cortical cataracts, and 50% of controls (49/98) were homozygous for the null GSTM1 allele. Twenty-five percent of patients (26/102) with cortical cataracts, 24% (7/29) with nuclear cataracts, 31% with mixed nuclear and cortical cataracts, and 27% of controls (26/98) displayed only the A allele for GSTM1. Twenty-four percent of patients (24/102) with cortical cataract, 24% (7/29) with nuclear cataracts, 14% (10/71) with mixed nuclear and cortical cataract, and 18% of controls showed only the B allele for GSTM1. Two percent of patients (2/102) with cortical cataracts, 7% (2/29) with nuclear cataracts, 4% (3/71) with mixed nuclear and cortical cataracts, and 5% of controls (5/98) showed both A and B alleles for GSTM1. CONCLUSIONS: No associations between the GSTM1 alleles, including the null allele, and cataracts were detected in this study. SN - 0146-0404 UR - https://www.unboundmedicine.com/medline/citation/8631631/Glutathione_S_transferase_M1_genotype_and_age_related_cataracts__Lack_of_association_in_an_Italian_population_ L2 - https://iovs.arvojournals.org/article.aspx?volume=37&issue=6&page=1167 DB - PRIME DP - Unbound Medicine ER -